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Found 361 with Last Name = 'kinghorn' and Initial = 'ad'
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50057527(4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50478894(Anabaenopeptin G)
Affinity DataIC50:  2nMAssay Description:Inhibition of carboxypeptidase A (unknown origin) assessed as reduction in hydrolysis of hippuryl-L-phenylalanine using hippuryl-L-phenylalanine as s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Oryctolagus cuniculus)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50035612(CHEMBL96926 | OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of rabbit skeletal muscle SERCA1 assessed as reduction in calcium uptake preincubated for 10 mins followed by ATP addition and measured af...More data for this Ligand-Target Pair
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Affinity DataIC50:  31nMAssay Description:Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  70nMAssay Description:Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  75nMAssay Description:Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  75nMAssay Description:Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  80nMAssay Description:Inhibition of nuclear factor NF-kappa-B p65 subunit after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50593519(CHEMBL5204252)
Affinity DataIC50:  96nMAssay Description:Inhibition of chymotrypsin-like activity of human erythrocytes 20S proteasome using Suc-LLVY-AMC as substrate and measured by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAromatase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50251003(CHEMBL457679 | cid_5318585 | isolicoflavonol)
Affinity DataIC50:  100nMAssay Description:Inhibition of aromatase from human placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50251002((2S)-2',4'-dihydroxy-2' '-(1-hydroxy-1-methylethyl...)
Affinity DataIC50:  100nMAssay Description:Inhibition of aromatase from human placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  120nMAssay Description:Inhibition of TNF alpha stimulated NF-KappaB p65 in human HeLa nuclear extract assessed as decrease in NF-KappaB translocation to nucleus measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, cytosolic 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50292380(10'-D-glucopyranosyl-1,8,1',8'-tetrahydroxy-3,3'-b...)
Affinity DataIC50:  160nMAssay Description:Inhibition of Sprague-Dawley rat cytosolic aldehyde dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldehyde dehydrogenase, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50292380(10'-D-glucopyranosyl-1,8,1',8'-tetrahydroxy-3,3'-b...)
Affinity DataIC50:  360nMAssay Description:Inhibition of Sprague-Dawley rat mitochondrial aldehyde dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAromatase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50251004((2S)-abyssinone II | CHEMBL457680)
Affinity DataIC50:  400nMAssay Description:Inhibition of aromatase from human placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target7-dehydrocholesterol reductase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50412080(CHEMBL342394)
Affinity DataIC50:  400nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50269597(3-(2,3-dihydroxy-3-methylbutyl)resveratrol | CHEMB...)
Affinity DataIC50:  480nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50250979(3'-[gamma-hydroxymethyl-(E)-gamma-methylallyl]-2,4...)
Affinity DataIC50:  500nMAssay Description:Inhibition of aromatase from human placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50250915(CHEMBL512578 | moracin M)
Affinity DataIC50:  500nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, cytosolic 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50292380(10'-D-glucopyranosyl-1,8,1',8'-tetrahydroxy-3,3'-b...)
Affinity DataIC50:  530nMAssay Description:Inhibition of Sprague-Dawley rat cytosolic aldehyde dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPapain(Carica papaya)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50513777(CHEMBL4534212)
Affinity DataIC50:  600nMAssay Description:Inhibition of Papaya papain using Z-FR-MCA as substrate by spectrofluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target7-dehydrocholesterol reductase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50412077((+)-PACHYSAMINE B)
Affinity DataIC50:  600nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target7-dehydrocholesterol reductase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50412082(CHEMBL455316)
Affinity DataIC50:  600nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50269596(3-(gamma,gamma-dimethylallyl)resveratrol | CHEMBL4...)
Affinity DataIC50:  610nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50292380(10'-D-glucopyranosyl-1,8,1',8'-tetrahydroxy-3,3'-b...)
Affinity DataIC50:  720nMAssay Description:Inhibition of Sprague-Dawley rat mitochondrial aldehyde dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM23926((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM23926((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50108046((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50463331(CHEMBL4204109)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50513779(CHEMBL4441556)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of trypsin (unknown origin) using Z-FR-MCA as substrate by spectrofluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50463328(CHEBI:1368 | CHEMBL451476)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of p50 after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50317857(Artorigidin A | CHEMBL1094756)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTaste receptor type 2 member 31(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50384791(CHEMBL490162)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292441(1beta-hydroxyaleuritolic acid 3-p-hydroxybenzoate ...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50251005((2S)-5,7,2',4'-tetrahydroxyflavanone | (S)-2-(2,4-...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of aromatase from human placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Bos taurus (bovine))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50478892(Anabaenopeptin T)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of carboxypeptidase A in bovine pancreas assessed as reduction in hydrolysis of hippuryl-L-phenylalanine using hippuryl-L-phenylalanine as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50317859(CHEMBL1099162 | artobiloxanthone)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTaste receptor type 2 member 31(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50384790(CHEMBL210692)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target7-dehydrocholesterol reductase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50412076(CHEMBL457817)
Affinity DataIC50:  2.80E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50346334(1,3,7-trihydroxy-2,4-diisoprenylxanthone | CHEMBL1...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50250510(CHEMBL462879 | GARCINONE D)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of nuclear factor NF-kappa-B p65 subunit after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50478513(2Alpha-Hydroxymaprounic Acid | CHEMBL469925)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50251006((2S)-Euchrenone a7 | CHEMBL457686)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of aromatase from human placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target7-dehydrocholesterol reductase(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50412083(CHEMBL458033)
Affinity DataIC50:  3.50E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTaste receptor type 2 member 31(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50312648((2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-d...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50317859(CHEMBL1099162 | artobiloxanthone)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50259651(CHEMBL518935 | resveratrol (E)-dehydrodimer | resv...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50478893(Anabaenopeptin H)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of carboxypeptidase A (unknown origin) assessed as reduction in hydrolysis of hippuryl-L-phenylalanine using hippuryl-L-phenylalanine as s...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
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