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Found 557 with Last Name = 'lair' and Initial = 'c'
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataKi:  0.0390nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296785((S)-N-(2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50255069((S)-2-(5,7-dimethyl-2-oxo-3-(2-oxo-2-(2'-oxo-1,1',...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296784((S)-2-(6-methyl-2,5-dioxo-2,4,5,6-tetrahydro-1H-im...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296789(2-(2a-methyl-4-oxo-2a,3,4,5-tetrahydropyrrolo[4,3,...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296787(CHEMBL564088 | N-((S)-2'-oxo-1,1',2',3-tetrahydros...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296787(CHEMBL564088 | N-((S)-2'-oxo-1,1',2',3-tetrahydros...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254446((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254446((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50255036((S)-N-(2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3...)
Affinity DataKi:  0.610nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224431(CHEMBL236593 | MK-0974 | N-[(3R,6S)-6-(2,3-difluor...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Sanofi Synthelabo

Curated by PDSP Ki Database
LigandPNGBDBM35723(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Affinity DataKi:  0.830nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50255067((S)-N-(2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3...)
Affinity DataKi:  0.870nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
Sanofi Synthelabo

Curated by PDSP Ki Database
LigandPNGBDBM35723(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296790(CHEMBL549503 | N-((S)-2'-oxo-1,1',2',3-tetrahydros...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50255037(CHEMBL463880 | N-((S)-2'-oxo-1,1',2',3-tetrahydros...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(MOUSE)
Sanofi Synthelabo

Curated by PDSP Ki Database
LigandPNGBDBM35723(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Affinity DataKi:  1.26nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296786((S)-2-(1-methyl-2-oxo-2,3-dihydropyrrolo[4,3,2-de]...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
Sanofi Synthelabo

Curated by PDSP Ki Database
LigandPNGBDBM35723(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50255068((S)-N-(2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50246312((R)-2-(5,7-dimethyl-3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296791(CHEMBL564466 | N-((S)-2'-oxo-1,1',2',3-tetrahydros...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50255035((S)-N-(2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254977(CHEMBL473445 | N-(2'-oxo-1,1',2',3-tetrahydrospiro...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50377961(CHEMBL1162991)
Affinity DataKi:  7.10nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296788(2-((S)-5-methyl-4-oxo-2a,3,4,5-tetrahydropyrrolo[4...)
Affinity DataKi:  9.70nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254979((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254978((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  16nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195956((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  20nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195943(CHEMBL220101 | N-((R)-3-methyl-2,5-dioxo-1',3'-dih...)
Affinity DataKi:  20nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192559((R)-4-(2-oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl...)
Affinity DataKi:  22nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254901((R)-N-(5-oxo-2-phenyl-1,1',3',5-tetrahydrospiro[im...)
Affinity DataKi:  34nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50255005((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  35nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254899(CHEMBL464263 | N-(2',5'-dioxo-1,3-dihydrospiro[ind...)
Affinity DataKi:  96nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Mus musculus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50107595((S)-1-(2-Amino-2-carboxyethyl)-6,7-dihydro-1H-cycl...)
Affinity DataKi:  109nMAssay Description:Binding affinity towards GluR1 receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254937((R)-N-(5-oxo-2-(pyridin-3-yl)-1,1',3',5-tetrahydro...)
Affinity DataKi:  130nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50107595((S)-1-(2-Amino-2-carboxyethyl)-6,7-dihydro-1H-cycl...)
Affinity DataKi:  218nMAssay Description:Binding affinity towards Ionotropic glutamate receptor AMPA 2 from rat brainMore data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254857((R)-N-(2,5-dioxo-1',3'-dihydrospiro[imidazolidine-...)
Affinity DataKi:  230nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254858(CHEMBL465280 | N-(2'-oxo-1,3-dihydrospiro[indene-2...)
Affinity DataKi:  270nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254939(CHEMBL515087 | N-(2'-oxo-1,3-dihydrospiro[indene-2...)
Affinity DataKi:  520nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192575((R)-4-(2,4-dioxoimidazolidin-1-yl)-N-(2-oxo-5-phen...)
Affinity DataKi:  520nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50102484(2-(2-Amino-3-hydroxy-butyrylamino)-2-hydroxy-succi...)
Affinity DataKi:  600nMAssay Description:Inhibitory activity against EAAC1 (EAAT3) in absence of L-glutamic acid.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50107595((S)-1-(2-Amino-2-carboxyethyl)-6,7-dihydro-1H-cycl...)
Affinity DataKi:  1.76E+3nMAssay Description:Binding affinity towards GluR4 receptor from rat brainMore data for this Ligand-Target Pair
TargetGlutamate receptor 3(RAT)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50107595((S)-1-(2-Amino-2-carboxyethyl)-6,7-dihydro-1H-cycl...)
Affinity DataKi:  2.14E+3nMAssay Description:Binding affinity towards Ionotropic glutamate receptor AMPA 3 from rat brainMore data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184075((R)-4-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)-N-(...)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254938((R)-N-(2-cyclopropyl-5-oxo-1,1',3',5-tetrahydrospi...)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254900(CHEMBL464264 | N-(2'-oxo-1,3-dihydrospiro[indene-2...)
Affinity DataKi:  2.70E+3nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50102484(2-(2-Amino-3-hydroxy-butyrylamino)-2-hydroxy-succi...)
Affinity DataKi:  4.90E+3nMAssay Description:Inhibitory activity against EAAC1 (EAAT3) in presence of 20 uM L-glutamic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50102486(2-Phenyl-4,5-dihydro-oxazole-4,5-dicarboxylic acid...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibitory activity against EAAC1 (EAAT3) in absence of L-glutamic acid in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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