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Found 135 with Last Name = 'lea' and Initial = 'wa'
TargetSomatostatin receptor type 4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50068039(1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)...)
Affinity DataKi:  17nMAssay Description:Binding affinity to human SST4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50496732(CHEMBL1591268)
Affinity DataKi:  19nMAssay Description:Binding affinity to human SST4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50496735(CHEMBL1355048)
Affinity DataKi:  26nMAssay Description:Binding affinity to human SST4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50496733(CHEMBL1591395)
Affinity DataKi:  160nMAssay Description:Binding affinity to human SST4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50496734(CHEMBL1590268)
Affinity DataKi:  690nMAssay Description:Binding affinity to human SST4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center For Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM18428(Aminoquinoline compound, 1 | N-[4-methyl-2-(morpho...)
Affinity DataIC50:  30nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center For Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM50182801((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Affinity DataIC50:  30nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM228659((+)-2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophe...)
Affinity DataIC50:  30nMAssay Description:The activity of IDH1 R132H and IDH1 R132C was measured in 384-well plates by coupling NADPH consumption to a diaphorase/resazurin-based detection sys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM35361((5-oxidanidyl-4-thiophen-2-ylcarbonyl-1,2,5-oxadia...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM228658(rac-ML309)
Affinity DataIC50:  62nMAssay Description:The activity of IDH1 R132H and IDH1 R132C was measured in 384-well plates by coupling NADPH consumption to a diaphorase/resazurin-based detection sys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300734(4-thienoyl-3-cyanofuroxan | CHEMBL576265)
Affinity DataIC50:  63nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM228659((+)-2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophe...)
Affinity DataIC50:  68nMAssay Description:The activity of IDH1 R132H and IDH1 R132C was measured in 384-well plates by coupling NADPH consumption to a diaphorase/resazurin-based detection sys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM228658(rac-ML309)
Affinity DataIC50:  96nMAssay Description:The activity of IDH1 R132H and IDH1 R132C was measured in 384-well plates by coupling NADPH consumption to a diaphorase/resazurin-based detection sys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center For Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM18438(4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2...)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300756(3-formyl-4-phenyl-1,2,5-oxadiazole 2-oxide | CHEMB...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center For Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM50396168(CHEMBL1361379)
Affinity DataIC50:  280nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300760(4,4'-(thiophene-2,4-diyl)bis(3-cyano-1,2,5-oxadiaz...)
Affinity DataIC50:  350nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center For Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM50068039(1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)...)
Affinity DataIC50:  360nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center For Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM18447(2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrroli...)
Affinity DataIC50:  400nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300761(4,4'-(thiophene-2,5-diyl)bis(3-cyano-1,2,5-oxadiaz...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300762(4,4'-(5-fluoro-1,3-phenylene)bis(3-cyano-1,2,5-oxa...)
Affinity DataIC50:  480nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300755(3-carboxy-4-phenyl-1,2,5-oxadiazole 2-oxide | CHEM...)
Affinity DataIC50:  630nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center For Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM50068039(1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)...)
Affinity DataIC50:  710nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398032(CHEMBL1603014)
Affinity DataIC50:  750nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398032(CHEMBL1603014)
Affinity DataIC50:  940nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300763(4,4'-(1,4-phenylene)bis(3-cyano-1,2,5-oxadiazole 2...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398022(CHEMBL2181097)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398022(CHEMBL2181097)
Affinity DataIC50:  1.46E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398020(CHEMBL2181103)
Affinity DataIC50:  1.63E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398020(CHEMBL2181103)
Affinity DataIC50:  1.63E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398029(CHEMBL2180814)
Affinity DataIC50:  1.88E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center For Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM18428(Aminoquinoline compound, 1 | N-[4-methyl-2-(morpho...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300753(3-cyano-4-(3-nitrophenyl)-1,2,5-oxadiazole 2-oxide...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398029(CHEMBL2180814)
Affinity DataIC50:  2.37E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300752(3-cyano-4-(3-(trifluoromethyl)phenyl)-1,2,5-oxadia...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300750(4-(3-bromophenyl)-3-cyano-1,2,5-oxadiazole 2-oxide...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300736(3-cyano-4-(furan-2-yl)-1,2,5-oxadiazole 2-oxide | ...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300751(4-(3-bromo-4-fluorophenyl)-3-cyano-1,2,5-oxadiazol...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEyes absent homolog 2 [253-538](Homo sapiens (Human))
University of Colorado School of Medicine

LigandPNGBDBM231626(NCGC00249327)
Affinity DataIC50:  2.90E+3nMpH: 6.5 T: 2°CAssay Description:Eya activity was measured in 50-μl reactions using black, 96-well, half-volume microtiter plates (Greiner Bio-one) with the substrate OMFP (3-O-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398028(CHEMBL2180816)
Affinity DataIC50:  2.91E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center For Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM18438(4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398027(CHEMBL2181089)
Affinity DataIC50:  3.26E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398028(CHEMBL2180816)
Affinity DataIC50:  3.26E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300735(3-cyano-4-(thiophen-2-yl)-1,2,5-oxadiazole 2-oxide...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300748(4-(4-bromophenyl)-3-cyano-1,2,5-oxadiazole 2-oxide...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300749(4-(3-chlorophenyl)-3-cyano-1,2,5-oxadiazole 2-oxid...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300759(4,4'-(1,3-phenylene)bis(3-cyano-1,2,5-oxadiazole 2...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398027(CHEMBL2181089)
Affinity DataIC50:  3.66E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398024(CHEMBL2181095)
Affinity DataIC50:  3.66E+3nMAssay Description:Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50300747(4-(4-chlorophenyl)-3-cyano-1,2,5-oxadiazole 2-oxid...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Schistosoma mansoni TGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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