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Found 133 with Last Name = 'lin' and Initial = 'yc'
TargetHIV-1 protease(Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM586099(BDBM50064200 | TL-3)
Affinity DataKi:  1.5nM ΔG°:  -52.4kJ/molepH: 5.6 T: 2°CAssay Description:Inhibition of HIV-protease activity for selected acids at P3-P3' positions. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataKi:  1.70nM IC50:  6nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
Ligand InfoMMDBPC cidPC sid
In DepthDetails ArticlePubMedMMDB

TargetHIV-1 protease(Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM586090(P3-P3' Entry 8)
Affinity DataKi:  2nM ΔG°:  -51.6kJ/molepH: 5.6 T: 2°CAssay Description:Inhibition of HIV-protease activity for selected acids at P3-P3' positions. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataKi:  2.70nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair
Ligand InfoMMDBPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84461(HIV-1 PR Inhibitor, compound 8)
Affinity DataKi:  4nM IC50:  13nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200943(CHEMBL269769 | cyclopentyl (2S,3S)-3-[4-([4-(5-chl...)
Affinity DataKi:  8nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84461(HIV-1 PR Inhibitor, compound 8)
Affinity DataKi:  9.70nM IC50:  17nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataKi:  10nM IC50:  19nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
Ligand InfoMMDBPC cidPC sid
In DepthDetails ArticlePubMedMMDB

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200945(CHEMBL262751 | cyclopentyl (2S,3S)-3-[4-([4-(2,5-d...)
Affinity DataKi:  10nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84461(HIV-1 PR Inhibitor, compound 8)
Affinity DataKi:  13nM IC50:  24nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200956(CHEMBL262496 | cyclopentyl (2S,3S)-3-[4-([4-(2,5-d...)
Affinity DataKi:  14nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200944(CHEMBL407802 | cyclopentyl (2S,3S)-3-(4-((4-(5-chl...)
Affinity DataKi:  21nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataKi:  22nM IC50:  39nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
Ligand InfoMMDBPC cidPC sid
In DepthDetails ArticlePubMedMMDB

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200949(CHEMBL262738 | cyclopentyl (2S,3S)-3-[4-([4-(5-chl...)
Affinity DataKi:  23nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200954(CHEMBL386849 | cyclopentyl (2S,3S)-3-[4-([4-(2,5-D...)
Affinity DataKi:  25nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataKi:  27nM IC50:  46nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
Ligand InfoMMDBPC cidPC sid
In DepthDetails ArticlePubMedMMDB

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200951(CHEMBL267645 | cyclopentyl (2S,3S)-3-[4-([4-(2,5-d...)
Affinity DataKi:  27nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200953(CHEMBL405393 | cyclopentyl (2S,3S)-3-(4-((4-(5-chl...)
Affinity DataKi:  28nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84461(HIV-1 PR Inhibitor, compound 8)
Affinity DataKi:  30nM IC50:  52nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200948(CHEMBL386847 | cyclopentyl (2S,3S)-3-[4-([4-(2,5-d...)
Affinity DataKi:  32nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200958(CHEMBL428624 | cyclopentyl (2S,3S)-3-[4-([4-(2,5-d...)
Affinity DataKi:  42nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438750(CHEMBL2414884)
Affinity DataKi:  71nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200950((R)-tetrahydrofuran-3-yl (2S,3S)-3-(4-((4-(5-chlor...)
Affinity DataKi:  83nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200955(CHEMBL218359 | cyclopentyl (2S,3S)-5-methyl-1-phen...)
Affinity DataKi:  86nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200946(CHEMBL385816 | cyclopentyl (2S,3S)-1,4-diphenyl-3-...)
Affinity DataKi:  98nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438752(CHEMBL2414882)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438754(CHEMBL2414880)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438753(CHEMBL2414881)
Affinity DataKi:  1.00E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438748(CHEMBL2414879)
Affinity DataKi:  1.10E+3nMAssay Description:Non-competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM18358((2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-...)
Affinity DataKi:  1.30E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200952(CHEMBL407996 | N-((2S,3S)-3-(4-((4-(5-chloro-2-met...)
Affinity DataKi: >2.50E+3nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200947(CHEMBL405122 | cyclopentyl (2S,3S)-3-[4-([4-(2,5-d...)
Affinity DataKi: >2.50E+3nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438751(CHEMBL2414883)
Affinity DataKi:  3.20E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438749(CHEMBL2414888)
Affinity DataKi:  4.10E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50200957(CHEMBL216912 | [(1S,2S)-2-azido-1,2-dibenzylethyl]...)
Affinity DataKi:  3.10E+4nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50096449((S)-2-[(R)-1-((1S,2R,3R,4S)-1-Benzyl-2,3-dihydroxy...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration of the compound against TL3-resistant HIV(V82A) mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataIC50:  6nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair
Ligand InfoMMDBPC cidPC sid
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM586090(P3-P3' Entry 8)
Affinity DataIC50:  6nMpH: 5.6 T: 2°CAssay Description:Inhibition of HIV-protease activity for selected acids at P3-P3' positions. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50096447((2R,3S)-3-{(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-p...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration of the compound against drug-resistant HIV(G48V) mutant proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50096451((2R,3S)-3-[(S)-2-((S)-2-Acetylamino-3-phenyl-propi...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration of the compound against TL3-resistant HIV(L63P) mutant proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50096445((2R,3S)-3-{(S)-2-[(S)-2-Acetylamino-3-(1H-indol-3-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of the compound against TL3-resistant HIV(V771) mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM586084(P3-P3' Entry 2)
Affinity DataIC50:  10nMpH: 5.6 T: 2°CAssay Description:Inhibition of HIV-protease activity for selected acids at P3-P3' positions. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM586088(P3-P3' Entry 6)
Affinity DataIC50:  10nMpH: 5.6 T: 2°CAssay Description:Inhibition of HIV-protease activity for selected acids at P3-P3' positions. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM586089(P3-P3' Entry 7)
Affinity DataIC50:  10nMpH: 5.6 T: 2°CAssay Description:Inhibition of HIV-protease activity for selected acids at P3-P3' positions. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM586094(P3-P3' Entry 12)
Affinity DataIC50:  10nMpH: 5.6 T: 2°CAssay Description:Inhibition of HIV-protease activity for selected acids at P3-P3' positions. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM586095(P3-P3' Entry 13)
Affinity DataIC50:  10nMpH: 5.6 T: 2°CAssay Description:Inhibition of HIV-protease activity for selected acids at P3-P3' positions. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM586098(P3-P3' Entry 16)
Affinity DataIC50:  10nMpH: 5.6 T: 2°CAssay Description:Inhibition of HIV-protease activity for selected acids at P3-P3' positions. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50096445((2R,3S)-3-{(S)-2-[(S)-2-Acetylamino-3-(1H-indol-3-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of the compound against TL3-resistant HIV(V82A) mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50096447((2R,3S)-3-{(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-p...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration of the compound against drug-resistant HIV(G48V) mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50096451((2R,3S)-3-[(S)-2-((S)-2-Acetylamino-3-phenyl-propi...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration of the compound against TL3-resistant HIV(V82A) mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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