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Found 983 with Last Name = 'luo' and Initial = 'hb'
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataKi:  7nMAssay Description:Binding affinity to PDE9A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50443370(CHEMBL3086276)
Affinity DataKi:  17nMAssay Description:Competitive inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Affinity DataKi:  1.03E+4nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50059989((1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-phenyl)-he...)
Affinity DataKi:  1.82E+4nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  2.44E+4nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50295287(2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)ace...)
Affinity DataKi:  8.78E+4nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50027952(5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acet...)
Affinity DataKi:  3.35E+5nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataKi:  3.83E+5nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Affinity DataKi:  8.43E+5nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50408487(CHEMBL5281567)
Affinity DataIC50:  0.0600nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50408486(CHEMBL5268340)
Affinity DataIC50:  0.130nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50497974(CHEMBL3319209)
Affinity DataIC50:  0.180nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50513787(CHEMBL4445635)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human PDE10A2 catalytic domain (446 to 789 residues) expressed in Escherichia coli BL21 cells using [3H]-cGMP as substrate after 15 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459162(CHEMBL4218772)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of human PDE10A2 catalytic domain (446 to 789 residues) expressed in Escherichia coli BL21 cells using [3H]-cGMP as substrate after 15 min...More data for this Ligand-Target Pair
LigandPNGBDBM50398017(CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of P-glycoprotein expressed in MDCK-MDR1 cells by calcein AM assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459175(CHEMBL4204687)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PDE4D2 (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50513788(CHEMBL4558162)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of human PDE10A2 catalytic domain (446 to 789 residues) expressed in Escherichia coli BL21 cells using [3H]-cGMP as substrate after 15 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50419436(CHEMBL1915747 | US9138494, JNJ-41510417)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459172(CHEMBL4217826)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50034641(CHEMBL3360415)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50034641(CHEMBL3360415)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PDE9A2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at human EP1 receptor expressed in CHO cells receptor by NFTA reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50513799(CHEMBL4527952)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of human PDE10A2 catalytic domain (446 to 789 residues) expressed in Escherichia coli BL21 cells using [3H]-cGMP as substrate after 15 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM290889(1-[2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl]-...)
Affinity DataIC50:  0.770nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459173(CHEMBL4209550)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50530262(CHEMBL4456564)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of PDE10 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50530262(CHEMBL4456564)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of PDE10 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540037(CHEMBL4639341)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))TBA
LigandPNGBDBM107767(US11419874, PF-05180999 | US8598155, 2)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))TBA
LigandPNGBDBM566472(3-(8-methoxy-1- methyl-2-oxo-7- phenyl-2,3-dihydro...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50513795(CHEMBL4459590)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PDE10A2 catalytic domain (446 to 789 residues) expressed in Escherichia coli BL21 cells using [3H]-cGMP as substrate after 15 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50034645(CHEMBL3360419)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PDE9A2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459164(CHEMBL4215845)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50034648(CHEMBL3360421)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PDE9A2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459162(CHEMBL4218772)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PDE6C catalytic domain (1 to 858 residues) (unknown origin) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459166(CHEMBL4206819)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50444038(CHEMBL3092563 | US9669035, B-5)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50540040(CHEMBL4640793)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459169(CHEMBL4214877)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459170(CHEMBL4209964)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50569589(CHEMBL4863742)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50530258(CHEMBL4437555)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PDE10 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50530258(CHEMBL4437555)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PDE10 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50408479(CHEMBL5180503)
Affinity DataIC50:  1.70nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50543967(CHEMBL4638644)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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