Affinity DataKi: 9.60E+3nMAssay Description:Inhibition of caspase 1 (unknown origin) using N-acetyl-Tyr-Val-Ala-Asp-para-nitroanilide substrate assessed as rate of para-nitroanilide release by ...More data for this Ligand-Target Pair
Affinity DataKi: 1.06E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using N-acetyl-Tyr-Val-Ala-Asp-para-nitroanilide substrate assessed as rate of para-nitroanilide release by ...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Activity of COX2 in human heparinized blood assessed as inhibition of LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Activity of COX2 in human heparinized blood assessed as inhibition of LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human AKR1C3 His5Gln mutant expressed in Escherichia coli BL21 (DE) Codon Plus RP cells assessed as r...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of AKR1C3 (unknown origin) using S-tetralol as substrate in presence of NADP+ by fluorimteryMore data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of FLAG-tagged HDAC2 (unknown origin) expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetri...More data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of FLAG-tagged HDAC2 (unknown origin) expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetri...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of type-1 human steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 610nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 610nMAssay Description:Inhibition of human COX2 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 740nMAssay Description:Inhibition of FLAG-tagged HDAC2 (unknown origin) expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetri...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of Amyloid beta (1 to 42) (unknown origin) aggregation assessed as amount of fibrils formation after 2 hrs by thioflavin T based spectrofl...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 940nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human AKR1C3 His5Gln mutant expressed in Escherichia coli BL21 (DE) Codon Plus RP cells assessed as r...More data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC1 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC1 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC1 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC3 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC3 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC3 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Activity of COX2 in human heparinized blood assessed as inhibition of LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Activity of COX2 in human heparinized blood assessed as inhibition of LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Amyloid beta (1 to 42) (unknown origin) aggregation assessed as amount of fibrils formation after 2 hrs by thioflavin T based spectrofl...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of COX1 in human whole blood assessed as TxB2 production after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of Amyloid beta (1 to 42) (unknown origin) aggregation assessed as amount of fibrils formation after 2 hrs by thioflavin T based spectrofl...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 3.56E+3nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 4.29E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 4.38E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of COX1 in human whole blood assessed as TxB2 production after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nMAssay Description:Activity of COX2 in human heparinized blood assessed as inhibition of LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 7.35E+3nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human AKR1C3 His5Gln mutant expressed in Escherichia coli BL21 (DE) Codon Plus RP cells assessed as r...More data for this Ligand-Target Pair
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of Amyloid beta (1 to 42) (unknown origin) aggregation assessed as amount of fibrils formation after 2 hrs by thioflavin T based spectrofl...More data for this Ligand-Target Pair