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Target
Aldo-keto reductase family 1 member C2
Ligand
BDBM17636
Substrate
n/a
Meas. Tech.
ChEMBL_1718560 (CHEMBL4133560)
IC50
530±n/a nM
Citation
 Pippione, AC; Giraudo, A; Bonanni, D; Carnovale, IM; Marini, E; Cena, C; Costale, A; Zonari, D; Pors, K; Sadiq, M; Boschi, D; Oliaro-Bosso, S; Lolli, ML Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach. Eur J Med Chem 139:936-946 (2017) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member C2
Synonyms:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 3-alpha-Hydroxysteroid Dehydrogenase Type 3 (AKR1C2) | Chlordecone reductase homolog HAKRD | Aldo-keto reductase family 1 member C2 (AK1C2) | 3-alpha-HSD3 | Dihydrodiol dehydrogenase 2 | Type III 3-alpha-hydroxysteroid dehydrogenase | Aldo-keto reductase family 1 member C2 (AK1C2a) | DD-2 | DD/BABP | Dihydrodiol dehydrogenase/bile acid-binding protein | Aldo-keto reductase family 1 member C2 (AKR1C2) | AK1C2_HUMAN | AKR1C2 | DDH2
Type:
Enzyme
Mol. Mass.:
36739.89
Organism:
Human
Description:
n/a
Residue:
323
Sequence:
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY
  
Inhibitor
Name:
BDBM17636
Synonyms:
2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid | CHEMBL23588 | Nichisedan | Arlef | Flufenamic acid | US9271961, Flufenamic Acid | US20240002326, Compound Flufenamic acid
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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