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Found 304 with Last Name = 'mccammon' and Initial = 'ja'
TargetAdenosine deaminase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50407749(CHEMBL2112110)
Affinity DataKi:  0.00250nMAssay Description:Binding affinity towards Adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50369126(CONFORMYCIN)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity towards Adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481568(CHEMBL592712)
Affinity DataKi:  62nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM51599(3-[3-[(5-ethyl-[1,2,4]triazin[5,6-b]indol-3-yl)thi...)
Affinity DataKi:  100nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Pseudomonas aeruginosa)
University of Illinois

LigandPNGBDBM228817(IspH inhibitor, 8)
Affinity DataKi:  500nMAssay Description:In order to find new inhibitors, we carried out in silico screening of AaIspH and EcIspH using ZINC and National Cancer Institute (NCI) libraries and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus)
University of Illinois

LigandPNGBDBM228818(8-Amino-3-benzyl-2,3,4,4 a-tetrahydro-1,2'H,6H...)
Affinity DataKi:  700nMAssay Description:In order to find new inhibitors, we carried out in silico screening of AaIspH and EcIspH using ZINC and National Cancer Institute (NCI) libraries and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Escherichia coli (Enterobacteria))
University of Illinois

LigandPNGBDBM228818(8-Amino-3-benzyl-2,3,4,4 a-tetrahydro-1,2'H,6H...)
Affinity DataKi:  3.00E+3nMAssay Description:In order to find new inhibitors, we carried out in silico screening of AaIspH and EcIspH using ZINC and National Cancer Institute (NCI) libraries and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50057418(CHEMBL3326435)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50057411(CHEMBL3326430)
Affinity DataKi:  3.80E+4nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50057412(CHEMBL3326429)
Affinity DataKi:  4.80E+4nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50057406(CHEMBL3326434)
Affinity DataKi:  6.40E+4nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50057410(CHEMBL3326431)
Affinity DataKi:  2.60E+5nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50057417(CHEMBL3326436)
Affinity DataKi:  2.70E+5nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM60985(1-hydroxy-2-pyridinethione | 1-hydroxypyridine-2-t...)
Affinity DataKi:  5.10E+5nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50057408(CHEMBL3326433)
Affinity DataKi:  9.50E+5nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50057414(CHEMBL3326439)
Affinity DataKi:  9.50E+5nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50057409(CHEMBL3326432)
Affinity DataKi:  2.30E+6nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50057415(CHEMBL3326438)
Affinity DataKi:  2.30E+6nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50057416(CHEMBL3326437)
Affinity DataKi: >1.00E+7nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of California At San Diego

Curated by ChEMBL
LigandPNGBDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Affinity DataIC50:  0.0740nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of California At San Diego

Curated by ChEMBL
LigandPNGBDBM50473233(CHEMBL38655)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of California At San Diego

Curated by ChEMBL
LigandPNGBDBM50473235(CHEMBL38726)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of California At San Diego

Curated by ChEMBL
LigandPNGBDBM50473234(CHEMBL287775)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of California At San Diego

Curated by ChEMBL
LigandPNGBDBM50473236(CHEMBL38575)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University of California San Diego

LigandPNGBDBM82186(AM-5)
Affinity DataIC50:  10nMAssay Description:Inhibition assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University of California San Diego

LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50:  19nMAssay Description:Inhibition assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM7501(4-{(Z)-[4,6-dihydroxy-7-(1-methylpiperidin-4-yl)-3...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Cyclin-dependent kinase 2 (CDK2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153301(BPH-1463)
Affinity DataIC50:  31nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153302(BPH-948)
Affinity DataIC50:  36nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153303(BPH-1256)
Affinity DataIC50:  41nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153304(BPH-1477)
Affinity DataIC50:  43nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  47nMAssay Description:Inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153305(BPH-1264)
Affinity DataIC50:  68nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153306(BPH-1247)
Affinity DataIC50:  119nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481568(CHEMBL592712)
Affinity DataIC50:  120nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
University Of California

Curated by ChEMBL
LigandPNGBDBM50073630(2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]...)
Affinity DataIC50:  130nMAssay Description:Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153307(BPH-1167)
Affinity DataIC50:  133nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153308(BPH-1467)
Affinity DataIC50:  138nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  140nMAssay Description:Inhibition of human Cathepsin V using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
University Of California

Curated by ChEMBL
LigandPNGBDBM50073630(2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]...)
Affinity DataIC50:  150nMAssay Description:Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153309(BPH-1466)
Affinity DataIC50:  156nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153310(BPH-1461)
Affinity DataIC50:  164nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose 3,5-epimerase(Mycobacterium tuberculosis H37Rv)
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM51599(3-[3-[(5-ethyl-[1,2,4]triazin[5,6-b]indol-3-yl)thi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlC expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153311(BPH-1294 | BPH-1296)
Affinity DataIC50:  205nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM153312(BPH-1432)
Affinity DataIC50:  210nMpH: 7.5Assay Description:We screened an in-house library of 43 compounds using GPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by DPPS w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTuberculosinyl adenosine transferase(Mycobacterium tuberculosis H37Rv)
University of California San Diego

LigandPNGBDBM25288(BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...)
Affinity DataIC50:  210nMAssay Description:For inhibition assay of Rv3378c, using tuberculosinyl diphosphate and adenosine as substrates, a mixture of 100 µM TPP, 100 µM adenosine,75 µg/mL Rv3...More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
University of California San Diego

LigandPNGBDBM50241504(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50:  240nMAssay Description:Inhibition assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
University Of California

Curated by ChEMBL
LigandPNGBDBM50056908((1R,3R,4S,5R)-3,4-Bis-[(E)-3-(3,4-dihydroxy-phenyl...)
Affinity DataIC50:  250nMAssay Description:Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
University Of California

Curated by ChEMBL
LigandPNGBDBM50056908((1R,3R,4S,5R)-3,4-Bis-[(E)-3-(3,4-dihydroxy-phenyl...)
Affinity DataIC50:  250nMAssay Description:Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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