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Found 186 with Last Name = 'qiao' and Initial = 'w'
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50293451(1-Methyl-1-[2-(7-oxo-7H-1-aza-benzo[de]anthracen-9...)
Affinity DataKi:  0.310nMAssay Description:Inhibition of electric eel AChE by LB plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)TBA
LigandPNGBDBM210929(UCP1172)
Affinity DataKi:  1.80nMAssay Description:Inhibition of Escherichia coli DHFRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230555(CHEMBL5267078)
Affinity DataKi:  2nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)TBA
LigandPNGBDBM50608616(CHEMBL5287382)
Affinity DataKi:  4nMAssay Description:Inhibition of wild type Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetDihydrofolate reductase(Escherichia coli)TBA
LigandPNGBDBM50608614(CHEMBL1724189)
Affinity DataKi:  7.80nMAssay Description:Inhibition of Escherichia coli DHFR assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230554(CHEMBL5283523)
Affinity DataKi:  9.40nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230554(CHEMBL5283523)
Affinity DataKi:  13nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50293452(1-methyl-1-(3-(7-oxo-7H-dibenzo[de,g]quinoline-4-c...)
Affinity DataKi:  110nMAssay Description:Inhibition of electric eel AChE by LB plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50211247(9-Amino-1-azabenzanthrone | 9-amino-1-aza-benzo[de...)
Affinity DataKi:  3.86E+3nMAssay Description:Inhibition of electric eel AChE by LB plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50293443(7-Oxo-7H-dibenzo[de,g]quinoline | CHEMBL559502)
Affinity DataKi:  1.46E+4nMAssay Description:Inhibition of electric eel AChE by LB plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)TBA
LigandPNGBDBM50108046((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Affinity DataKi:  3.15E+4nMAssay Description:Inhibition of Escherichia coli DHFR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDihydrofolate reductase(Escherichia coli)TBA
LigandPNGBDBM50608615(CHEBI:34383 | CHEMBL1162149)
Affinity DataKi:  3.59E+4nMAssay Description:Inhibition of Escherichia coli DHFR assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50014323(2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo...)
Affinity DataIC50:  0nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysisMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230550(CHEMBL5268799)
Affinity DataIC50:  0.430nMAssay Description:Binding affinity against Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50293451(1-Methyl-1-[2-(7-oxo-7H-1-aza-benzo[de]anthracen-9...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230550(CHEMBL5268799)
Affinity DataIC50:  0.670nMAssay Description:Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis)TBA
LigandPNGBDBM50608610(CHEMBL5279457)
Affinity DataIC50:  0.960nMAssay Description:Inhibition of Mycobacterium tuberculosis DHFRMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50166256(5-[4-(4-Bromo-phenoxy)-phenyl]-5-(4-isopropyl-pipe...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50329819((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Affinity DataIC50:  1.5nMAssay Description:Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataIC50:  2.40nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230543(CHEMBL5283576)
Affinity DataIC50:  2.60nMAssay Description:Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50293446(CHEMBL556249 | Diethyl-methyl-[2-(7-oxo-7H-1-aza-b...)
Affinity DataIC50:  2.62nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)TBA
LigandPNGBDBM50335530((S)-3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-d...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of wild type Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50398607(ONX 0912 | OPROZOMIB | US10640533, Identification ...)
Affinity DataIC50:  3nMAssay Description:Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50093572(CHEMBL3585766)
Affinity DataIC50:  3nMAssay Description:Binding affinity against Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
Affinity DataIC50:  3.40nMAssay Description:Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230552(CHEMBL5267731)
Affinity DataIC50:  3.70nMAssay Description:Binding affinity against Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50:  4nMAssay Description:Binding affinity against Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230551(CHEMBL5281153)
Affinity DataIC50:  4.40nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor determined as pA2 in guinea pig tracheaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230551(CHEMBL5281153)
Affinity DataIC50:  4.80nMAssay Description:Binding affinity against Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50211244(CHEMBL395926 | Trimethyl-[2-(7-oxo-7H-1-aza-benzo[...)
Affinity DataIC50:  4.81nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50095487(CHEMBL8796 | Cyclohexanecarboxylic acid (1-cyano-a...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50095487(CHEMBL8796 | Cyclohexanecarboxylic acid (1-cyano-a...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis)TBA
LigandPNGBDBM50608612(CHEMBL1904209)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant Mycobacterium tuberculosis DHFR using dihydrofolate as substrate preincubated for 1 min followed by substrate addition and ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50277889(CARFILZOMIB | CHEMBL451887)
Affinity DataIC50:  6nMAssay Description:Inhibition of human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProteasome subunit beta type-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230543(CHEMBL5283576)
Affinity DataIC50:  8nMAssay Description:Inhibition of human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam and testosterone as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)TBA
LigandPNGBDBM50536186(CHEMBL4483572)
Affinity DataIC50:  15nMAssay Description:Inhibition of wild type Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)TBA
LigandPNGBDBM50608617(CHEMBL5284400)
Affinity DataIC50:  18nMAssay Description:Inhibition of wild type Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysisMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mycobacterium tuberculosis)TBA
LigandPNGBDBM50608609(CHEMBL586115 | TCMDC-124259)
Affinity DataIC50:  22nMAssay Description:Inhibition of Mycobacterium tuberculosis DHFRMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetProteasome subunit beta type-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataIC50:  24nMAssay Description:Evaluated for norepinephrine as agonist.More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50166256(5-[4-(4-Bromo-phenoxy)-phenyl]-5-(4-isopropyl-pipe...)
Affinity DataIC50:  26nMAssay Description:Binding affinity against Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50264809(2-((4-phenoxyphenylsulfonyl)methyl)thiirane | CHEM...)
Affinity DataIC50:  28nMAssay Description:Binding affinity against Dihydrofolate reductase of chicken liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
Affinity DataIC50:  31nMAssay Description:In vitro relative blocking action (pA2) of the post-synaptic Alpha-1 adrenergic receptor from rat and rabbit aortaMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230543(CHEMBL5283576)
Affinity DataIC50:  33nMAssay Description:Evaluated for norepinephrine as agonist.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50093572(CHEMBL3585766)
Affinity DataIC50:  33nMAssay Description:Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230552(CHEMBL5267731)
Affinity DataIC50:  36nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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