TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Mahidol University
Mahidol University
Affinity DataKi: 0.0110nM ΔG°: -62.5kJ/mole IC50: 0.570nMpH: 7.0 T: 2°CAssay Description:The concentration of inhibitor that inhibited 50% of the parasite growth (IC50) was determined from the sigmoidal curve obtained by plotting the perc...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Mahidol University
Mahidol University
Affinity DataKi: 0.0200nM ΔG°: -61.1kJ/mole IC50: 2.30nMpH: 7.0 T: 2°CAssay Description:The concentration of inhibitor that inhibited 50% of the parasite growth (IC50) was determined from the sigmoidal curve obtained by plotting the perc...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase [N51I,C59R,S108N,I164L](Plasmodium falciparum (isolate K1 / Thailand))
Mahidol University
Mahidol University
Affinity DataKi: 0.0370nM ΔG°: -59.5kJ/mole IC50: 18nMpH: 7.0 T: 2°CAssay Description:The concentration of inhibitor that inhibited 50% of the parasite growth (IC50) was determined from the sigmoidal curve obtained by plotting the perc...More data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Mahidol University
Mahidol University
Affinity DataKi: 0.200nM ΔG°: -55.4kJ/mole IC50: 80nMpH: 7.0 T: 2°CAssay Description:The concentration of inhibitor that inhibited 50% of the parasite growth (IC50) was determined from the sigmoidal curve obtained by plotting the perc...More data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Mahidol University
Mahidol University
Affinity DataKi: 0.300nM ΔG°: -54.4kJ/mole IC50: 37nMpH: 7.0 T: 2°CAssay Description:The concentration of inhibitor that inhibited 50% of the parasite growth (IC50) was determined from the sigmoidal curve obtained by plotting the perc...More data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Antagonist activity at rat CB1 receptor in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:Antagonist activity at rat CB1 receptor in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 0.430nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 0.440nMAssay Description:Inhibition of human bradykinin B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
Affinity DataKi: 0.590nMAssay Description:Inhibition of human bradykinin B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.670nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 0.830nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 0.830nMAssay Description:Antagonist activity at rat CB1 receptor in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 0.870nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.910nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 0.920nMAssay Description:Antagonist activity at rat bradykinin B1 receptorMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 1.20nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Irreversible inhibition of human FGFR2 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Irreversible inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated with enzyme followed by peptide substrate addition by ca...More data for this Ligand-Target Pair
Affinity DataKi: 1.66nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 1.75nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 1.97nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 2nM ΔG°: -50.5kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 2nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 2.06nMAssay Description:Antagonist activity at rat CB1 receptor in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Irreversible inhibition of human FGFR3 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.84nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 3.5nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute of The Novartis Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 4nM ΔG°: -48.7kJ/molepH: 7.2 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6nM ΔG°: -46.9kJ/molepH: 7.5 T: 2°CAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Mahidol University
Mahidol University
Affinity DataKi: 6.20nM ΔG°: -46.8kJ/mole IC50: 2.40E+3nMpH: 7.0 T: 2°CAssay Description:The concentration of inhibitor that inhibited 50% of the parasite growth (IC50) was determined from the sigmoidal curve obtained by plotting the perc...More data for this Ligand-Target Pair
Affinity DataKi: 6.70nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair