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Found 612 with Last Name = 'snyder' and Initial = 'jp'
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50091614(CHEMBL3582347)
Affinity DataKi:  0.300nMAssay Description:Inhibition of carbonic anhydrase-2 (unknown origin) incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50091598(CHEMBL3582349)
Affinity DataKi:  0.770nMAssay Description:Inhibition of carbonic anhydrase-2 (unknown origin) incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50091688(CHEMBL3582345)
Affinity DataKi:  2.60nMAssay Description:Inhibition of carbonic anhydrase-2 (unknown origin) incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50091613(CHEMBL3582348)
Affinity DataKi:  2.70nMAssay Description:Inhibition of carbonic anhydrase-2 (unknown origin) incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50091619(CHEMBL3582346)
Affinity DataKi:  3.90nMAssay Description:Inhibition of carbonic anhydrase-2 (unknown origin) incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

US Patent
LigandPNGBDBM168618(US9079852, Table F, Compound 3)
Affinity DataKi:  553nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

US Patent
LigandPNGBDBM168620(US9079852, Table F, Compound 5)
Affinity DataKi:  1.00E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

US Patent
LigandPNGBDBM168617(US9079852, Table F, Compound 2)
Affinity DataKi:  1.60E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

US Patent
LigandPNGBDBM168626(US9079852, Table F, Compound 11)
Affinity DataKi:  5.00E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

US Patent
LigandPNGBDBM168625(US9079852, Table F, Compound 10)
Affinity DataKi:  7.50E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

US Patent
LigandPNGBDBM168622(US9079852, Table F, Compound 7)
Affinity DataKi:  7.50E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

US Patent
LigandPNGBDBM168621(US9079852, Table F, Compound 6)
Affinity DataKi:  7.50E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H2 receptor(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440057(CHEMBL2426097)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of histamine H2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

US Patent
LigandPNGBDBM168624(US9079852, Table F, Compound 9)
Affinity DataKi:  1.00E+4nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

US Patent
LigandPNGBDBM168619(US9079852, Table F, Compound 4)
Affinity DataKi:  1.30E+4nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

US Patent
LigandPNGBDBM168616(US9079852, Table F, Compound 1)
Affinity DataKi:  3.90E+4nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50225416(CHEMBL393882 | TN-14003)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of CXCR4 in MDA-MB-231 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50347490(CHEMBL1802333)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at human CXCR4 expressed in human U87 cells expressing CD4 assessed as inhibition of CXCL12-induced cAMP production pretreated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443545(CHEMBL3091683)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of SDF-1alpha-mediated calcium flux preincubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367254(ENALAPRILAT)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory concentration against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50225415(CHEMBL237830 | N,N'-di-2-pyridinyl-1,4-benzenedime...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at human CXCR4 expressed in human U87 cells expressing CD4 assessed as inhibition of CXCL12-induced cAMP production pretreated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50452268(CHEMBL2114219)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration (isomer B) against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443541(CHEMBL3091687)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of SDF-1alpha-mediated calcium flux preincubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443543(CHEMBL3091685)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of SDF-1alpha-mediated calcium flux preincubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2/cyclinE assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50033743(7-[3-(2-Cyclopropylmethyl-3-methoxy-4-thiazol-4-yl...)
Affinity DataIC50:  3.20nMAssay Description:Binding affinity of the compound towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443544(CHEMBL3091684)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of SDF-1alpha-mediated calcium flux preincubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50021267(2-(1-Carboxymethyl-2-oxo-azocan-3-ylamino)-4-pheny...)
Affinity DataIC50:  4.80nMAssay Description:Inhibitory concentration (isomer B) against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443541(CHEMBL3091687)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at CXCR4 in human MAGI-CCR5 cells assessed as inhibition of HIV-1 3B entry after 2 to 6 days by beta-galactosidase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50033744(7-{3-[3-Methoxy-2-propyl-4-(3H-[1,2,3]triazol-4-yl...)
Affinity DataIC50:  5.20nMAssay Description:Binding affinity of the compound towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50347491(CHEMBL1802329)
Affinity DataIC50:  5.40nMAssay Description:Antagonist activity at human CXCR4 expressed in human U87 cells expressing CD4 assessed as inhibition of CXCL12-induced cAMP production pretreated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443546(CHEMBL3091682)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of SDF-1alpha-mediated calcium flux preincubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443547(CHEMBL3091681)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of SDF-1alpha-mediated calcium flux preincubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50021268(2-(1-Carboxymethyl-2-oxo-azonan-3-ylamino)-4-pheny...)
Affinity DataIC50:  8.10nMAssay Description:Inhibitory concentration (isomer B) against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50033742(3-{7-[3-(2-Cyclopropylmethyl-3-methoxy-4-thiazol-4...)
Affinity DataIC50:  12.3nMAssay Description:Binding affinity of the compound towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443541(CHEMBL3091687)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at CXCR4 (unknown origin) assessed as inhibition of SDF-1-induced beta-arrestin recruitment incubated for 30 mins prior to SDF-1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50033753(4-[3-(2-Cyclopropylmethyl-3-methoxy-4-thiazol-4-yl...)
Affinity DataIC50:  15.5nMAssay Description:Binding affinity of the compound towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50021269(2-(1-Carboxymethyl-2-oxo-azepan-3-ylamino)-4-pheny...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration (isomer B) against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443541(CHEMBL3091687)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at CXCR4 (unknown origin) expressed in CHO-K1 cells assessed as inhibition of SDF-1alpha/forskolin-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443549(CHEMBL3091693)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at CXCR4 in human MAGI-CCR5 cells assessed as inhibition of HIV-1 3B entry after 2 to 6 days by beta-galactosidase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant AKT2 (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443548(CHEMBL3091694)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at CXCR4 in human MAGI-CCR5 cells assessed as inhibition of HIV-1 3B entry after 2 to 6 days by beta-galactosidase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant AKT1 (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347389(CHEMBL1801932)
Affinity DataIC50:  21nMAssay Description:Inhibition of CDK7/cyclinH/MAT1 assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50033747(7-[3-(2-Allyl-3-methoxy-4-thiazol-4-yl-phenoxy)-pr...)
Affinity DataIC50:  25nMAssay Description:Binding affinity for Leukotriene B4 (LTB4) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50033749(3-{7-[3-(3-Methoxy-2-propyl-4-thiazol-4-yl-phenoxy...)
Affinity DataIC50:  26nMAssay Description:Binding affinity for Leukotriene B4 (LTB4) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50315305((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-amin...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at CXCR4 in human PBMC assessed as inhibition of HIV-1 3B infectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50035696(1,1''-{1,4-phenylenebis(methylene)}-bis{1,4,8,11-t...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at CXCR4 in human PBMC assessed as inhibition of HIV-1 3B infectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443547(CHEMBL3091681)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at CXCR4 in human MAGI-CCR5 cells assessed as inhibition of HIV-1 3B entry after 2 to 6 days by beta-galactosidase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50:  33nMAssay Description:Inhibition of CDK1/cyclinB1 assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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