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Found 471 with Last Name = 'souza' and Initial = 's'
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of Mycobacterium tuberculosis PtpB assessed as inhibition constant using varying level of pNPP as substrate by Lineweaver-Burk...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataKi:  800nMAssay Description:Non-competitive inhibition of Mycobacterium tuberculosis PtpA assessed as inhibition constant using varying level of pNPP as substrate by Lineweaver-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataKi:  1.00E+3nMAssay Description:Competitive inhibition of PTP-PEST (unknown origin) assessed as inhibition constant using varying level of pNPP as substrate by Lineweaver-Burk plot ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataKi:  1.00E+3nMAssay Description:Non-competitive inhibition of Yersinia enterocolitica YopH assessed as inhibition constant using varying level of pNPP as substrate by Lineweaver-Bur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataKi:  1.40E+3nMAssay Description:Non-competitive inhibition of human PTP1B assessed as inhibition constant using varying level of pNPP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataKi:  1.90E+3nMAssay Description:Competitive inhibition of LYP (unknown origin) assessed as inhibition constant using varying level of pNPP as substrate by Lineweaver-Burk plot analy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50076273((2R,3R)-2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acry...)
Affinity DataKi:  1.25E+4nMAssay Description:Non-competitive mixed inhibition of Yersinia enterocolitica YopH assessed as inhibition constant for enzyme-substrate complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Saint John'S University

Curated by ChEMBL
LigandPNGBDBM50118216((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl di...)
Affinity DataKi:  1.30E+4nMAssay Description:Competitive inhibition of LMW-PTP isoform A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50076273((2R,3R)-2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acry...)
Affinity DataKi:  6.83E+4nMAssay Description:Non-competitive mixed inhibition of Yersinia enterocolitica YopH assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
School Of Health Sciences/Graduate Program In Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  6nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Tecnologia Em Fa??Rmacos

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  40nMAssay Description:Inhibition of RNA-dependent DNA polymerase activity of Human immunodeficiency virus 1 recombinant reverse transcriptase expressed in Escherichia coli...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBile salt export pump(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50367222(CHEMBL4162778)
Affinity DataIC50:  300nMAssay Description:Inhibition of human BSEP expressed in baculovirus infected Sf9 insect cell membrane vesicles assessed as reduction in ATP-dependent [3H]-taurocholic ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Tecnologia Em Fa??Rmacos

LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50:  500nMAssay Description:Inhibition of RNA-dependent DNA polymerase activity of Human immunodeficiency virus 1 recombinant reverse transcriptase expressed in Escherichia coli...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBile salt export pump(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50367218(CHEMBL4159416)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human BSEP expressed in baculovirus infected Sf9 insect cell membrane vesicles assessed as reduction in ATP-dependent [3H]-taurocholic ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505095(CHEMBL4483307)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human KLK7 assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKallikrein-5(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505092(CHEMBL4475417)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human KLK5 assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Tecnologia Em Fa??Rmacos

LigandPNGBDBM50479825(CHEMBL515099)
Affinity DataIC50:  1.98E+3nMAssay Description:Inhibition of polymerase activity of HIV1 recombinant reverse transcriptase expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505096(CHEMBL4436637)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of trypsin (unknown origin) assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Tecnologia Em Fa??Rmacos

LigandPNGBDBM50479824(CHEMBL474818)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of polymerase activity of HIV1 recombinant reverse transcriptase expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505096(CHEMBL4436637)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human KLK7 assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpBMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505092(CHEMBL4475417)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of trypsin (unknown origin) assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505095(CHEMBL4483307)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of trypsin (unknown origin) assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505092(CHEMBL4475417)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human KLK7 assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505093(CHEMBL4570538)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human KLK7 assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of Yersinia enterocolitica YopHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505098(CHEMBL4444324)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human KLK7 assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505094(CHEMBL4530207)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of human KLK7 assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50367220(CHEMBL4168422)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human BSEP expressed in baculovirus infected Sf9 insect cell membrane vesicles assessed as reduction in ATP-dependent [3H]-taurocholic ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human PTP1BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Tecnologia Em Fa??Rmacos

LigandPNGBDBM93122(3-Hydroxy-2-oxo-3-trifluoromethylindole, 25)
Affinity DataIC50:  3.41E+3nMAssay Description:Biological assay using HIV-1 reverse transcriptase.More data for this Ligand-Target Pair
In DepthDetails Article
TargetBile salt export pump(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50367219(CHEMBL4165147)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human BSEP expressed in baculovirus infected Sf9 insect cell membrane vesicles assessed as reduction in ATP-dependent [3H]-taurocholic ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-5(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505096(CHEMBL4436637)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human KLK5 assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Tecnologia Em Fa??Rmacos

LigandPNGBDBM93121(3-Hydroxy-2-oxo-3-trifluoromethylindole, 21)
Affinity DataIC50:  3.61E+3nMAssay Description:Biological assay using HIV-1 reverse transcriptase.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCytochrome P450 2C9(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-5(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505095(CHEMBL4483307)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human KLK5 assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Tecnologia Em Fa??Rmacos

LigandPNGBDBM50479826(CHEMBL473157)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of polymerase activity of HIV1 recombinant reverse transcriptase expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
School Of Health Sciences/Graduate Program In Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50548032(CHEMBL4785620)
Affinity DataIC50:  5.64E+3nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Tecnologia Em Fa??Rmacos

LigandPNGBDBM93119(3-Hydroxy-2-oxo-3-trifluoromethylindole, 16)
Affinity DataIC50:  6.07E+3nMAssay Description:Biological assay using HIV-1 reverse transcriptase.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCytochrome P450 1A2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
School Of Health Sciences/Graduate Program In Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50548029(CHEMBL4797608)
Affinity DataIC50:  6.99E+3nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Tecnologia Em Fa??Rmacos

LigandPNGBDBM93120(3-Hydroxy-2-oxo-3-trifluoromethylindole, 18)
Affinity DataIC50:  7.10E+3nMAssay Description:Biological assay using HIV-1 reverse transcriptase.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Homo sapiens (Human))
School Of Health Sciences/Graduate Program In Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50548031(CHEMBL4741157)
Affinity DataIC50:  7.34E+3nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKallikrein-5(Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50505093(CHEMBL4570538)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of human KLK5 assessed as reduction in enzyme activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataIC50:  8.15E+3nMAssay Description:Inhibition of radioligand binding to human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataIC50:  8.15E+3nMAssay Description:Inhibition of radioligand binding to human adrenergic alpha1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Tecnologia Em Fa??Rmacos

LigandPNGBDBM93123(3-Hydroxy-2-oxo-3-trifluoromethylindole, 26)
Affinity DataIC50:  8.37E+3nMAssay Description:Biological assay using HIV-1 reverse transcriptase.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Homo sapiens (Human))
School Of Health Sciences/Graduate Program In Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50548028(CHEMBL4800270)
Affinity DataIC50:  8.74E+3nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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