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Found 198 with Last Name = 'tsao' and Initial = 'd'
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25558(4-arylamino-3-pyridinecarbonitrile, 4p | 5-(3,4-di...)
Affinity DataKi:  79nM ΔG°:  -40.1kJ/mole IC50:  70nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25543(4-[(3-bromophenyl)amino]-5-(3,4-dimethoxyphenyl)py...)
Affinity DataKi:  4.90E+3nM ΔG°:  -30.0kJ/mole IC50:  4.60E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201921(2-Biphenyl-4-yl-6-fluoro-3-hydroxy-quinoline-4-car...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  5nMAssay Description:Inhibition of Abl 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  5nMAssay Description:Inhibition of FynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  5nMAssay Description:Inhibition of src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201923(3-hydroxy-2-(4'-hydroxy-biphenyl-4-yl)-quinoline-4...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201945(6-fluoro-3-hydroxy-2-(4-phenoxyphenyl)quinoline-4-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201925(2-BIPHENYL-4-YL-6-FLUORO-3-METHYL-QUINOLINE-4-CARB...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201919(6-fluoro-3-hydroxy-2-(4'-hydroxy-biphenyl-4-yl)-qu...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201905(3-hydroxy-2-(4-phenoxyphenyl)quinoline-4-carboxyli...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201949(2-biphenyl-4-yl-3-hydroxy-quinoline-4-carboxylic a...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201918(3-amino-2-biphenyl-4-yl-6-fluoro-quinoline-4-carbo...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  16nMAssay Description:Inhibition of HckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201939(6-fluoro-3-hydroxy-2-(4-(phenylthio)phenyl)quinoli...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  24nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  35nMAssay Description:Inhibition of LCK by LANCE FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  38nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25553(4-[(2,4-dichlorophenyl)amino]-5-(3,4-dimethoxyphen...)
Affinity DataIC50:  80nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25554(4-arylamino-3-pyridinecarbonitrile, 4l | 5-(3,4-di...)
Affinity DataIC50:  160nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378795(CHEMBL1215473)
Affinity DataIC50:  210nMAssay Description:Inhibition of acidic mammalian chitinase after 60 minsMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201900(6-bromo-2-(4-chlorophenyl)-3-hydroxyquinoline-4-ca...)
Affinity DataIC50:  211nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201940(2-(4-chlorophenyl)-3-hydroxy-6-methylquinoline-4-c...)
Affinity DataIC50:  217nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201913(2-(4-chlorophenyl)-3-hydroxy-6-(trifluoromethyl)qu...)
Affinity DataIC50:  270nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201934(2-(4-chlorophenyl)-6-fluoro-3-hydroxyquinoline-4-c...)
Affinity DataIC50:  312nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25551(4-arylamino-3-pyridinecarbonitrile, 4i | 5-(3,4-di...)
Affinity DataIC50:  400nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25555(4-[(2,5-dichlorophenyl)amino]-5-(3,4-dimethoxyphen...)
Affinity DataIC50:  470nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM72759(2-methyl-3-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of acidic mammalian chitinase after 60 minsMore data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25550(4-arylamino-3-pyridinecarbonitrile, 4h | 5-(3,4-di...)
Affinity DataIC50:  900nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201902(2-(4-chlorophenyl)-3-hydroxy-7,8-dimethylquinoline...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25546(4-arylamino-3-pyridinecarbonitrile, 4d | 5-(3,4-di...)
Affinity DataIC50:  1.40E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25544(4-arylamino-3-pyridinecarbonitrile, 4b | 5-(3,4-di...)
Affinity DataIC50:  1.60E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25560(4-(2,3-dihydro-1H-inden-5-ylamino)-5-(3,4-dimethox...)
Affinity DataIC50:  2.00E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201902(2-(4-chlorophenyl)-3-hydroxy-7,8-dimethylquinoline...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201930(6-fluoro-3-hydroxy-2-(4-hydroxyphenyl)quinoline-4-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25557(4-arylamino-3-pyridinecarbonitrile, 4o | 5-(3,4-di...)
Affinity DataIC50:  2.20E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25559(4-arylamino-3-pyridinecarbonitrile, 4q | 5-(3,4-di...)
Affinity DataIC50:  2.20E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25556(4-[(3,4-dichlorophenyl)amino]-5-(3,4-dimethoxyphen...)
Affinity DataIC50:  2.40E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25549(4-[(4-chlorophenyl)amino]-5-(3,4-dimethoxyphenyl)p...)
Affinity DataIC50:  2.80E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25545(4-[(3-chlorophenyl)amino]-5-(3,4-dimethoxyphenyl)p...)
Affinity DataIC50:  3.90E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201892(2-(4-chlorophenyl)-3-hydroxy-6-(trifluoromethoxy)q...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201902(2-(4-chlorophenyl)-3-hydroxy-7,8-dimethylquinoline...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201901(2-(4-chlorophenyl)-3-hydroxy-8-phenylquinoline-4-c...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human CYP2C8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201920(2-(4-chlorophenyl)-3-hydroxy-6,8-dimethylquinoline...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201902(2-(4-chlorophenyl)-3-hydroxy-7,8-dimethylquinoline...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201901(2-(4-chlorophenyl)-3-hydroxy-8-phenylquinoline-4-c...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM25552(4-arylamino-3-pyridinecarbonitrile, 4j | 5-(3,4-di...)
Affinity DataIC50:  8.40E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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