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Found 90 with Last Name = 'varghese' and Initial = 'ah'
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195572((R)-N,N-dimethyl-4'-(2-(2-phenylpiperidine-1-c...)
Affinity DataIC50: <5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195575((R)-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H-1...)
Affinity DataIC50:  5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195574((R)-(2-phenylpiperidin-1-yl)(3-(4-(pyridin-3-yl)ph...)
Affinity DataIC50:  5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195570((S)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)
Affinity DataIC50: <5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195581((2R,3R)-2-(3-ethynylphenyl)-1-(3-(4-(2-morpholinop...)
Affinity DataIC50:  5nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195571((R)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)
Affinity DataIC50: <5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195580((2R,3R)-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl...)
Affinity DataIC50:  6nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195575((R)-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H-1...)
Affinity DataIC50:  7nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195573((R)-4'-(1-(2-phenylpiperidine-1-carbonyl)-1H-1...)
Affinity DataIC50:  7nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216194(CHEMBL391935 | N-(2-chlorophenethyl)-N-(pyrrolidin...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195578((2R, 4R)-1-(3-(4-(2-morpholinopyrimidin-5-yl)pheny...)
Affinity DataIC50:  11nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195572((R)-N,N-dimethyl-4'-(2-(2-phenylpiperidine-1-c...)
Affinity DataIC50:  21nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078322(CHEMBL3414710)
Affinity DataIC50:  24nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078321(CHEMBL3414711 | US9260455, 7)
Affinity DataIC50:  25nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216201(CHEMBL233987 | N-(2-methoxyphenethyl)-4-(6-aza-bic...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078324(CHEMBL3414708 | US9260455, 8)
Affinity DataIC50:  30nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195574((R)-(2-phenylpiperidin-1-yl)(3-(4-(pyridin-3-yl)ph...)
Affinity DataIC50:  36nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216180(CHEMBL233799 | N-(2-methoxyphenethyl)-N-(pyrrolidi...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078349(CHEMBL3414707 | US9260455, 3)
Affinity DataIC50:  39nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195573((R)-4'-(1-(2-phenylpiperidine-1-carbonyl)-1H-1...)
Affinity DataIC50:  48nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195571((R)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)
Affinity DataIC50:  59nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078323(CHEMBL3414709)
Affinity DataIC50:  59nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078320(CHEMBL3414700 | US9260455, 4)
Affinity DataIC50:  59nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142394(US8933221, 4)
Affinity DataIC50:  61nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216199(4-(2-aza-bicyclo[2.2.1]heptan-2-ylmethyl)-N-(2-met...)
Affinity DataIC50:  95nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216188(CHEMBL233422 | N-(2-methoxyphenethyl)-4-(((1S,2S)-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216193(CHEMBL233609 | N-(2-methoxyphenethyl)-4-(((S)-2-(m...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078321(CHEMBL3414711 | US9260455, 7)
Affinity DataIC50:  150nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216197(CHEMBL233610 | N-(2-methoxyphenethyl)-4-(((S)-2-(m...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216181((R)-N-(2-methoxyphenethyl)-4-((diethylamino)methyl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216204(CHEMBL394028 | N-(2-methoxyphenethyl)-4-(piperidin...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142369(US8933221, 10)
Affinity DataIC50:  265nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078322(CHEMBL3414710)
Affinity DataIC50:  280nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216206(CHEMBL393989 | N-(2-methoxyphenethyl)-4-(benzyloxy...)
Affinity DataIC50:  310nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078352(CHEMBL3414705)
Affinity DataIC50:  375nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216191(CHEMBL232587 | N-(2,6-dichlorophenethyl)-4-((dieth...)
Affinity DataIC50:  430nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078323(CHEMBL3414709)
Affinity DataIC50:  470nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216187(CHEMBL232777 | N-(3-chlorophenethyl)-4-(benzyloxy)...)
Affinity DataIC50:  510nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216196(CHEMBL231776 | N-(2-methoxyphenethyl)-4-((diethyla...)
Affinity DataIC50:  540nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216183(CHEMBL233573 | N-(2-chlorophenethyl)-4-(benzyloxy)...)
Affinity DataIC50:  590nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078320(CHEMBL3414700 | US9260455, 4)
Affinity DataIC50:  670nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078349(CHEMBL3414707 | US9260455, 3)
Affinity DataIC50:  700nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195576(cis-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H...)
Affinity DataIC50:  710nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216207(CHEMBL233572 | N-(2-chlorophenethyl)-4-((diethylam...)
Affinity DataIC50:  840nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078351(CHEMBL3414703)
Affinity DataIC50:  850nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078324(CHEMBL3414708 | US9260455, 8)
Affinity DataIC50:  850nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216208((S)-N-(2-methoxyphenethyl)-4-((diethylamino)methyl...)
Affinity DataIC50:  970nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142394(US8933221, 4)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195579((2S,3S)-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl...)
Affinity DataIC50:  1.10E+3nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216186(CHEMBL232577 | N-(2-chlorophenethyl)-4-isopropoxy-...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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