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Target
Membrane-bound transcription factor site-1 protease
Ligand
BDBM50216181
Substrate
n/a
Meas. Tech.
ChEMBL_447771 (CHEMBL896780)
IC50
170±n/a nM
Citation
 Hay, BA; Abrams, B; Zumbrunn, AY; Valentine, JJ; Warren, LC; Petras, SF; Shelly, LD; Xia, A; Varghese, AH; Hawkins, JL; Van Camp, JA; Robbins, MD; Landschulz, K; Harwood, HJ Aminopyrrolidineamide inhibitors of site-1 protease. Bioorg Med Chem Lett 17:4411-4 (2007) [PubMed]  Article 
Target
Name:
Membrane-bound transcription factor site-1 protease
Synonyms:
KIAA0091 | MBTP1_HUMAN | MBTPS1 | S1P | SKI1
Type:
PROTEIN
Mol. Mass.:
117773.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_641529
Residue:
1052
Sequence:
MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAFNGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDHPNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNERTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKKIDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVVAGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKPQASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQNGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAEQTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTNFRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSLVIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTLANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGRIVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQINKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV
  
Inhibitor
Name:
BDBM50216181
Synonyms:
(R)-N-(2-methoxyphenethyl)-4-((diethylamino)methyl)-N-(pyrrolidin-3-yl)benzamide | CHEMBL233611 | PF-429242
Type:
Small organic molecule
Emp. Form.:
C25H35N3O2
Mol. Mass.:
409.5643
SMILES:
CCN(CC)Cc1ccc(cc1)C(=O)N(CCc1ccccc1OC)[C@@H]1CCNC1
Structure:
Search PDB for entries with ligand similarity: