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Target
Membrane-bound transcription factor site-1 protease
Ligand
BDBM50216201
Substrate
n/a
Meas. Tech.
ChEMBL_447771 (CHEMBL896780)
IC50
29±n/a nM
Citation
 Hay, BA; Abrams, B; Zumbrunn, AY; Valentine, JJ; Warren, LC; Petras, SF; Shelly, LD; Xia, A; Varghese, AH; Hawkins, JL; Van Camp, JA; Robbins, MD; Landschulz, K; Harwood, HJ Aminopyrrolidineamide inhibitors of site-1 protease. Bioorg Med Chem Lett 17:4411-4 (2007) [PubMed]  Article 
Target
Name:
Membrane-bound transcription factor site-1 protease
Synonyms:
KIAA0091 | MBTP1_HUMAN | MBTPS1 | S1P | SKI1
Type:
PROTEIN
Mol. Mass.:
117773.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_641529
Residue:
1052
Sequence:
MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAFNGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDHPNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNERTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKKIDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVVAGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKPQASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQNGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAEQTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTNFRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSLVIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTLANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGRIVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQINKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV
  
Inhibitor
Name:
BDBM50216201
Synonyms:
CHEMBL233987 | N-(2-methoxyphenethyl)-4-(6-aza-bicyclo[3.2.1]octan-6-ylmethyl)-N-(pyrrolidin-3-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C28H37N3O2
Mol. Mass.:
447.6123
SMILES:
COc1ccccc1CCN(C1CCNC1)C(=O)c1ccc(CN2CC3CC2CCC3)cc1 |w:11.11,25.27,27.30,THB:22:23:26:30.29.28|
Structure:
Search PDB for entries with ligand similarity: