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Found 148 with Last Name = 'waszczuk' and Initial = 'j'
TargetProgesterone receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at human PR expressed in CHO-K1 cells assessed as reduction in progesterone-induced response incubated for 20 hrs by luciferase r...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM25743(1-cycloheptyl-3-(1-acetylpiperidin-4-yl)urea | US8...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335965(1-(1-(isopropylsulfonyl)piperidin-4-yl)-3-(4-(trif...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335964(1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluorometh...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335966(1-Adamantan-1-yl-3-(1-methanesulfonyl-piperidin-4-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368944(CHEMBL4172624)
Affinity DataIC50:  1.90nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335967(1-(1-(isopropylsulfonyl)piperidin-4-yl)-3-(4-(trif...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50191854(CHEMBL436774 | N-(1-acetyl-piperidin-4-yl)-N'-(ada...)
Affinity DataIC50:  3nMAssay Description:Inhibition of mouse soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335968(1-(1-(methylsulfonyl)piperidin-4-yl)-3-(4-(trifluo...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335966(1-Adamantan-1-yl-3-(1-methanesulfonyl-piperidin-4-...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHETMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368933(CHEMBL4161754)
Affinity DataIC50:  5.60nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368971(CHEMBL4159987)
Affinity DataIC50:  5.60nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335969(1-(1-acetylpiperidin-4-yl)-3-(4,4-dimethylcyclohex...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335970(1-cyclohexyl-3-(1-picolinoylpiperidin-4-yl)urea | ...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335964(1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluorometh...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50191854(CHEMBL436774 | N-(1-acetyl-piperidin-4-yl)-N'-(ada...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368960(CHEMBL4159692)
Affinity DataIC50:  8.5nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368924(CHEMBL4167905 | US11124537, TABLE 3.47.1)
Affinity DataIC50:  9.60nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335971(1-(1-acetylpiperidin-4-yl)-3-(3-(trifluoromethyl)p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335972(1-(1-acetylpiperidin-4-yl)-3-(4-(trifluoromethyl)p...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Sus scrofa)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at GR in mini pig PBMC assessed as reduction in dexamethasone-induced GILZ gene expression incubated for 24 hrs by RT-qPCR methodMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368949(CHEMBL4164157)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368966(CHEMBL4164900 | US11124537, TABLE 3.20.2)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335967(1-(1-(isopropylsulfonyl)piperidin-4-yl)-3-(4-(trif...)
Affinity DataIC50:  13nMAssay Description:Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at GR in human OVCAR5 assessed as reduction in dexamethasone-induced FKBP5 gene expression incubated for 24 hrs by RT-qPCR methodMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368957(CHEMBL4171957)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335973(1-(1-acetylpiperidin-4-yl)-3-(4-tert-butylcyclohex...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335974(1-(1-Acetyl-piperidin-4-yl)-3-bicyclo[2.2.1]hept-7...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368936(CHEMBL4159430)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at GR in human PBMC assessed as reduction in dexamethasone-induced FKBP5 gene expression incubated for 6 hrs by RT-qPCR methodMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368945(CHEMBL4169685)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368925(CHEMBL4174418)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368948(CHEMBL4170986 | US11124537, TABLE 3.5.2)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368933(CHEMBL4161754)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at GR in human OVCAR5 assessed as reduction in dexamethasone-induced GILZ gene expression incubated for 24 hrs by RT-qPCR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368974(CHEMBL4161175 | US11124537, TABLE 3.6.1)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368932(CHEMBL4173222 | US11124537, TABLE 3.38.2)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at GR in human PBMC assessed as reduction in dexamethasone-induced GILZ gene expression incubated for 6 hrs by RT-qPCR methodMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368935(CHEMBL4166499 | US11124537, TABLE 3.4.1)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368934(CHEMBL4167332)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368938(CHEMBL4162539 | US11124537, TABLE 3.7.2)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Canis lupus familiaris)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at GR in dog PBMC assessed as reduction in dexamethasone-induced FKBP5 gene expression incubated for 6 hrs by RT-qPCR methodMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368933(CHEMBL4161754)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at GR in human PBMC assessed as reduction in dexamethasone-induced FKBP5 gene expression incubated for 6 hrs by RT-qPCR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Sus scrofa)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at GR in mini pig PBMC assessed as reduction in dexamethasone-induced FKBP5 gene expression incubated for 24 hrs by RT-qPCR metho...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368933(CHEMBL4161754)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at GR in human OVCAR5 assessed as reduction in dexamethasone-induced FKBP5 gene expression incubated for 24 hrs by RT-qPCR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368933(CHEMBL4161754)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at human PR expressed in CHO-K1 cells assessed as reduction in progesterone-induced response incubated for 20 hrs by luciferase r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368933(CHEMBL4161754)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at GR in human PBMC assessed as reduction in dexamethasone-induced GILZ gene expression incubated for 6 hrs by RT-qPCR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM50335975(1-(1-Acetyl-piperidin-4-yl)-3-(4-methyl-bicyclo[2....)
Affinity DataIC50:  25nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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