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Found 134 with Last Name = 'van hoorn' and Initial = 'wp'
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427749(CHEMBL2324924)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427748(CHEMBL2324925)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427749(CHEMBL2324924)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of wild type Abl1 kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427747(CHEMBL2324926)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type Abl1 kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427749(CHEMBL2324924)
Affinity DataIC50:  1nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427749(CHEMBL2324924)
Affinity DataIC50:  1nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427748(CHEMBL2324925)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type Abl1 kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427750(CHEMBL2324923)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of wild type Abl1 kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427749(CHEMBL2324924)
Affinity DataIC50:  2nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427750(CHEMBL2324923)
Affinity DataIC50:  2nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427748(CHEMBL2324925)
Affinity DataIC50:  3nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427747(CHEMBL2324926)
Affinity DataIC50:  6nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427748(CHEMBL2324925)
Affinity DataIC50:  7nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427742(CHEMBL2324930)
Affinity DataIC50:  8nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427748(CHEMBL2324925)
Affinity DataIC50:  10nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427750(CHEMBL2324923)
Affinity DataIC50:  11nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427745(CHEMBL2324927)
Affinity DataIC50:  12nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427747(CHEMBL2324926)
Affinity DataIC50:  12nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427750(CHEMBL2324923)
Affinity DataIC50:  12nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427741(CHEMBL2324931)
Affinity DataIC50:  13nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637532((3-amino-6-((1rs,2RS,3SR)-2,3- dimethylcyclopropyl...)
Affinity DataIC50:  13nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427744(CHEMBL2324928)
Affinity DataIC50:  14nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427742(CHEMBL2324930)
Affinity DataIC50:  15nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427750(CHEMBL2324923)
Affinity DataIC50:  15nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637523(US20230382911, Example 35 | [3-amino-6-(2,5-dihydr...)
Affinity DataIC50:  17nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637564((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50:  17nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427741(CHEMBL2324931)
Affinity DataIC50:  18nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637556((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50:  19nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637511(US20230382911, Example 23 | [3-amino-6-(cyclopente...)
Affinity DataIC50:  20nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427743(CHEMBL2324929)
Affinity DataIC50:  22nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637537((3-amino-6-(2,2- difluorocyclopropyl)-1H- pyrazolo...)
Affinity DataIC50:  22nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427747(CHEMBL2324926)
Affinity DataIC50:  24nMAssay Description:Inhibition of P38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637535(US20230382911, Example 47 | [3-amino-6-(2,5-dihydr...)
Affinity DataIC50:  25nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637563((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50:  26nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427741(CHEMBL2324931)
Affinity DataIC50:  27nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427747(CHEMBL2324926)
Affinity DataIC50:  27nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637521((3-amino-6-((1RS,2RS)-2- methylcyclopropyl)-1H- py...)
Affinity DataIC50:  28nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637522((3-amino-6-((1RS,2RS)-2- methylcyclopropyl)-1H-pyr...)
Affinity DataIC50:  29nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427745(CHEMBL2324927)
Affinity DataIC50:  30nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427744(CHEMBL2324928)
Affinity DataIC50:  31nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637565((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50:  31nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637528((3-amino-6-(2,2- difluorocyclopropyl)-1H- pyrazolo...)
Affinity DataIC50:  32nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637547((3RS,4RS)-4-(3-amino-6- cyclopropylpyrazolo[3,4- b...)
Affinity DataIC50:  33nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427744(CHEMBL2324928)
Affinity DataIC50:  33nMAssay Description:Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637531((3-amino-6-((1rs,2RS,3SR)-2,3- dimethylcyclopropyl...)
Affinity DataIC50:  35nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427748(CHEMBL2324925)
Affinity DataIC50:  35nMAssay Description:Inhibition of P38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637540((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50:  35nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427750(CHEMBL2324923)
Affinity DataIC50:  35nMAssay Description:Inhibition of P38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637540((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50:  36nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cyclofluidic

Curated by ChEMBL
LigandPNGBDBM50427743(CHEMBL2324929)
Affinity DataIC50:  36nMAssay Description:Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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