Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 152729,152730,152731,50405937,50438391,50438393,152729,152730,152731,50405937,50438391,50438393   

TargetAcetylpolyamine amidohydrolase(Mycoplana ramosa (Gram-negative bacterium))
University of Pennsylvania

LigandPNGBDBM152730(7-Amino-N-hydroxypentanamide (6))
Affinity DataIC50: 68nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 250 nM APAH (∼50% Zn2+ occupancy), 150 μM substrate, and 0−250 μM inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Zebrafish)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50438391(CHEMBL2413999)
Affinity DataIC50: 120nMAssay Description:Inhibition of zebrafish HDAC10 (2 to 675 residues) expressed in Escherichia coli BL21(DE3) cells using N-acetylputrescine as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylpolyamine amidohydrolase(Mycoplana ramosa (Gram-negative bacterium))
University of Pennsylvania

LigandPNGBDBM152729(6-Amino-N-hydroxypentanamide (5))
Affinity DataIC50: 130nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 250 nM APAH (∼50% Zn2+ occupancy), 150 μM substrate, and 0−250 μM inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetAcetylpolyamine amidohydrolase(Mycoplana ramosa (Gram-negative bacterium))
University of Pennsylvania

LigandPNGBDBM152731(8-Amino-N-hydroxypentanamide (7))
Affinity DataIC50: 150nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 250 nM APAH (∼50% Zn2+ occupancy), 150 μM substrate, and 0−250 μM inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetPeroxisomal N(1)-acetyl-spermine/spermidine oxidase(Human)
University of The Pacific

Curated by ChEMBL
LigandPNGBDBM50405937(CHEMBL173782)
Affinity DataKi:  180nMAssay Description:Inhibition of deacetylation of [acetyl-3H]-N8-Acetylspermidine deacetylase in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylpolyamine amidohydrolase(Mycoplana ramosa (Gram-negative bacterium))
University of Pennsylvania

LigandPNGBDBM50438391(CHEMBL2413999)
Affinity DataIC50: 390nMAssay Description:Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 8(Human)
University of Pennsylvania

LigandPNGBDBM152731(8-Amino-N-hydroxypentanamide (7))
Affinity DataIC50: 2.20E+3nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 500 nM HDAC8 enzyme, 150 μM Ac-Arg-His-Lys(Ac)-Lys(Ac)-aminomethylcoumarin substrate (BML-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Pennsylvania

LigandPNGBDBM152730(7-Amino-N-hydroxypentanamide (6))
Affinity DataIC50: 5.30E+3nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 500 nM HDAC8 enzyme, 150 μM Ac-Arg-His-Lys(Ac)-Lys(Ac)-aminomethylcoumarin substrate (BML-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Pennsylvania

LigandPNGBDBM152729(6-Amino-N-hydroxypentanamide (5))
Affinity DataIC50: 1.90E+4nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 500 nM HDAC8 enzyme, 150 μM Ac-Arg-His-Lys(Ac)-Lys(Ac)-aminomethylcoumarin substrate (BML-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetAcetylpolyamine amidohydrolase(Mycoplana ramosa (Gram-negative bacterium))
University of Pennsylvania

LigandPNGBDBM50405937(CHEMBL173782)
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAcetylpolyamine amidohydrolase(Mycoplana ramosa (Gram-negative bacterium))
University of Pennsylvania

LigandPNGBDBM50438393(CHEMBL2414007)
Affinity DataIC50: 1.80E+6nMAssay Description:Inhibition of Mycoplana ramosa APAH expressed in Escherichia coli BL21 (DE3) using BML-KI104 as substrate after 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed