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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
630
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Target
Muscarinic acetylcholine receptor M1
(Human)
Merck Sharp and Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 0.980nM
Assay Description:
Binding affinity towards human M1 muscarinic receptor.
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Target
Histone H1.0
(Human)
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
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Target
Histamine H1 receptor
(Human)
Intra-Cellular Therapies
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1nM
Assay Description:
Inhibition of histamine H1 receptor (unknown origin)
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Target
Histamine H1 receptor
(Human)
Intra-Cellular Therapies
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1.10nM
Assay Description:
Inhibition of [3H]-pyrilamine binding to human Histamine H1 receptor
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1.40nM
Assay Description:
Evaluated for binding affinity against alpha-1 adrenergic receptor
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1.40nM
Assay Description:
Binding affinity to human 5HT2A receptor
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Target
Histamine H1 receptor
(Human)
Intra-Cellular Therapies
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1.80nM
Assay Description:
Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting
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Target
Muscarinic acetylcholine receptor M1
(Human)
Merck Sharp and Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1.80nM
Assay Description:
Displacement of [3H]QNB from human M1 receptor by liquid scintillation counting
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Target
Histamine H1 receptor
(Human)
Intra-Cellular Therapies
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1.80nM
Assay Description:
Binding affinity to human cloned histamine H1 receptor
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Target
Serotonin 2 (5-HT2) receptor
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1.80nM
Assay Description:
Binding affinity determined in radioreceptor binding assay by using [3H]ketanserin radioligand against 5-hydroxytryptamine 2 receptor
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Target
Muscarinic acetylcholine receptor M1
(Human)
Merck Sharp and Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.80nM
Assay Description:
Binding affinity to human cloned muscarinic M1 receptor
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Target
Histamine H1 receptor
(Human)
Intra-Cellular Therapies
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 2.10nM
Assay Description:
Binding affinity towards human histamine H1 receptor
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Target
Muscarinic acetylcholine receptor M1
(Rat)
Yamanouchi Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 2.10nM
Assay Description:
Compound was tested for the binding affinity against rat cortical Muscarinic acetylcholine receptor M1 by radioligand [3H]-pirenzepine binding assay.
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Target
Histamine H1 receptor
(Human)
Intra-Cellular Therapies
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 2.38nM
Assay Description:
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells
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Target
Histamine H1 receptor
(Rat)
University of Siena
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 2.90nM
Assay Description:
In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 2.90nM
Assay Description:
Binding affinity to 5-HT2C receptor (unknown origin)
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Target
Alpha-2C adrenergic receptor
(Human)
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 2.90nM
Assay Description:
Inhibition of [3H]-rauwolscine binding to Alpha-2C adrenergic receptor
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 3nM
Assay Description:
Binding affinity to human 5HT2A receptor
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3nM
Assay Description:
Displacement of [3H]-Ketanserin from 5-HT2A receptor (unknown origin) incubated for 90 mins by microbeta counting method
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Target
5-hydroxytryptamine receptor 2B
(Human)
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cells
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 3.30nM
Assay Description:
Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptor
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Target
Serotonin 2 (5-HT2) receptor
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 3.70nM
Assay Description:
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.
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Target
Histamine H1 receptor
(Guinea pig)
Huazhong University of Science and Technology
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 3.80nM
Assay Description:
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis
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Target
Serotonin 2 (5-HT2) receptor
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 3.80nM
Assay Description:
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 4nM
Assay Description:
Displacement of [3H]-LSD from human 5-HT6 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 4nM
Assay Description:
Binding affinity for human 5-hydroxytryptamine 2A receptor
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 4nM
Assay Description:
Binding affinity towards human 5-hydroxytryptamine 6 receptor
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 4nM
Assay Description:
Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK293 cells after 1 hr
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 4nM
Assay Description:
Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 4nM
Assay Description:
Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1 hr
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 4nM
Assay Description:
Displacement of [3H]prazosin from alpha-1 adrenergic receptor of rat brain homogenate
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 4.80nM
Assay Description:
Binding affinity against human 5-hydroxytryptamine 6 receptor stably transfected to HEK 293 human embryonic kidney cells using [3H]-lysergic acid die...
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 4.80nM
Assay Description:
Binding affinity to 5HT2C receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 4.84nM
Assay Description:
Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in CHO cells after 60 mins by liquid scintillation counting
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Target
Serotonin 2 (5-HT2) receptor
(Human)
Ucb Pharma
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 5nM
Assay Description:
In vitro binding affinity for 5-hydroxytryptamine 2 receptor
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 5nM
Assay Description:
Tested in vitro for its ability to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat frontal cortex membranes
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 5nM
Assay Description:
In vitro ability to displace [3H]ketanserin binding from 5-hydroxytryptamine 2A receptor in rat striatal membrane.
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 5nM
Assay Description:
Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cells
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Target
Histamine H1 receptor
(Rat)
University of Siena
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 5nM
Assay Description:
Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 5nM
Assay Description:
Binding affinity towards human 5-HT2A receptor in BEK cells
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 5nM
Assay Description:
Binding affinity towards human 5-hydroxytryptamine 2C receptor
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 5.40nM
Assay Description:
Antagonist activity at 5HT2A receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 5.40nM
Assay Description:
Binding affinity to 5-HT2A receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 6.05nM
Assay Description:
Displacement of [3H]ketanserin from 5HT2A receptor in rat cortical membrane
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Target
Muscarinic acetylcholine receptor M1
(Human)
Merck Sharp and Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 6.30nM
Assay Description:
Displacement of [3H]pirenzepine from human M1 receptor expressed in CHO cells
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Target
5-hydroxytryptamine receptor 7
(Rat)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 6.30nM
Assay Description:
Binding affinity towards rat 5-hydroxytryptamine 7 receptor
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 6.30nM
Assay Description:
Inhibition of [125I]-R91150 binding to human 5-hydroxytryptamine 2A receptor
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 6.40nM
Assay Description:
Binding affinity to 5-HT1A receptor (unknown origin)
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 6.62nM
Assay Description:
Displacement of [3H]7-OH-DPAT from human Dopamine receptor D3
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 6.70nM
Assay Description:
In vitro binding affinity at serotonin 5-hydroxytryptamine 2A receptor in rat cortical membrane
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Target
Histamine H1 receptor
(Guinea pig)
Huazhong University of Science and Technology
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 6.80nM
Assay Description:
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 6.87nM
Assay Description:
Displacement of [3H]spiperone from human Dopamine receptor D2
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 7.10nM
Assay Description:
Binding affinity to dopamine D2 receptor (unknown origin)
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 7.27nM
Assay Description:
Displacement of [3H]spiperone from human Dopamine receptor D4
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Target
D(1A) dopamine receptor
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 7.5nM
Assay Description:
Binding affinity to dopamine D1 receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 7.60nM
Assay Description:
Compound was measured for the inhibition of [3H]ketanserin binding to rat frontal cortex membrane (5-HT2A receptor)
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 7.80nM
Assay Description:
In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in human using [3H]ketanserin as radioligand
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Target
Histamine H1 receptor
(Guinea pig)
Huazhong University of Science and Technology
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 7.90nM
Assay Description:
Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 7.90nM
Assay Description:
Displacement of [3H]mesulergine from 5HT2C receptor expressed in CHO cells
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 7.90nM
Assay Description:
Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells
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Target
5-hydroxytryptamine receptor 2C
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 8nM
Assay Description:
Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 2C receptor
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 8nM
Assay Description:
Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2A serotonin receptor.
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 8nM
Assay Description:
Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 2A receptor
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Target
5-hydroxytryptamine receptor 2C
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 8nM
Assay Description:
Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2C serotonin receptor.
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 8.60nM
Assay Description:
Binding affinity to 5-HT2A receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 8.90nM
Assay Description:
Displacement of [3H]ketanserin from 5HT2A in rat brain cerebral cortex after 20 mins by scintillation counting
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 8.90nM
Assay Description:
Binding affinity to human 5HT1A receptor
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 8.90nM
Assay Description:
Binding affinity to human cloned 5HT2A receptor
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9nM
Assay Description:
In vitro binding affinity towards alpha-1 adrenergic receptor in rat frontal cortex homogenate using of [3H]prazosin as radioligand
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9nM
Assay Description:
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9nM
Assay Description:
Compound was evaluated for its binding affinity towards rat 5-hydroxytryptamine 2A receptor
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Target
D(4) dopamine receptor
(Rat)
Pharmacia & Upjohn
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9nM
Assay Description:
Binding affinity of [3H]-spiperone towards cloned mammalian Dopamine receptor D4 expressed in cultured cells or from rat whole brain
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9nM
Assay Description:
Binding affinity towards human dopamine D4 receptor was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9.10nM
Assay Description:
Displacement of [3H]ketanserin human cloned serotonin 5HT2A receptor
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9.10nM
Assay Description:
Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release measured fo...
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9.10nM
Assay Description:
Binding affinity towards serotonin 5-hydroxytryptamine 2A receptor
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9.12nM
Assay Description:
Displacement of [3H]ketanserin from human cloned 5HT2A receptor
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9.12nM
Assay Description:
Displacement of [3H]ketanserin from human cloned 5HT2A receptor
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9.30nM
Assay Description:
Displacement of [3H]mesulergine from human 5HT2C receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9.40nM
Assay Description:
Binding affinity measured at the 5-hydroxytryptamine 2A receptor by the inhibition of [3H]-ketanserin binding to rat cortex using unlabeled mianserin...
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9.5nM
Assay Description:
Binding affinity towards human 5-hydroxytryptamine 6 receptor was evaluated using [3H]-LSD as radioligand
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9.60nM
Assay Description:
Displacement of [125]DOI from human recombinant full length 5HT2A receptor expressed in HEK293E cells
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9.60nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Binding affinity towards serotonin 5-hydroxytryptamine 2C receptor
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Displacement of [3H]prazosin from adrenergic alpha1 receptor in rat cerebral cortex
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Inhibition of human dopamine D4 receptor
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Displacement of [3H]mesulergine human cloned serotonin 5HT2C receptor
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometry
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometry
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in rat tissue homogenate using [3H]ketanserin as radioligand
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Binding affinity towards human Dopamine receptor D4.2 in CHO cells
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex homogenate
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Target
Serotonin 2 (5-HT2) receptor
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]-Spiperone as the radioligand in rat cortical tissue.
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Binding affinity towards cloned human Dopamine receptor D4 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligand
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Ki: <10nM
Assay Description:
Antagonist activity at human recombinant 5-HT6 receptor assessed as inhibition of serotonin-induced cAMP accumulation
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
compound was tested for its affinity to displace [3H]-spiperone cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10nM
Assay Description:
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 6 receptor
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Ki: 10nM
Assay Description:
Binding affinity to 5HT2A receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Ki: 10nM
Assay Description:
Inhibition of [3H]-ketanserin binding to rat 5-hydroxytryptamine 2A receptor
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10.5nM
Assay Description:
Displacement of [3H]mesulergine from human 5HT2C receptor
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 10.5nM
Assay Description:
Displacement of [3H]mesulergine from human cloned 5HT2C receptor
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 11nM
Assay Description:
Binding affinity to human cloned 5HT6 receptor
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Ki: 11nM
Assay Description:
Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
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Target
Alpha-1B adrenergic receptor
(Rat)
Intra-Cellular Therapies
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Ki: 12nM
Assay Description:
Inhibition of rat adrenergic alpha1B receptor
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Target
Histamine H1 receptor
(Guinea pig)
Huazhong University of Science and Technology
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 12nM
Assay Description:
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 7
(Rat)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Ki: 13nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 7 receptor
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5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 13nM
Assay Description:
Displacement of [3H]-ketanserin from human 5-HT2AR expressed in CHO-K1 cell membranes after 1.5 hrs by microbeta counting method
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Target
Muscarinic acetylcholine receptor M4
(Human)
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Ki: 13nM
Assay Description:
Displacement of [3H]4-DAMP from human M4 receptor expressed in CHO cells
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 13nM
Assay Description:
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 13nM
Assay Description:
Displacement of [125]DOI from human recombinant full length 5HT2C receptor expressed in HEK293E cells
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 13nM
Assay Description:
Displacement of [3H]-YM-09151-2 from human Dopamine receptor D4.2 expressed in baculovirus Sf9 cells
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Ki: 13nM
Assay Description:
Binding affinity towards human serotonin 5-hydroxytryptamine 2C receptor
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 13nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Ki: 13nM
Assay Description:
Binding affinity at 5HT2A receptor in rat striatal membranes
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Target
Histamine H1 receptor
(Rat)
University of Siena
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Ki: 14nM
Assay Description:
Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 14nM
Assay Description:
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 15nM
Assay Description:
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 15nM
Assay Description:
Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 15nM
Assay Description:
Displacement of [3H]ketanserin from human 5-HT2A receptor measured after 90 mins by microbeta scintillation counting method
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 15.8nM
Assay Description:
Ability to displace [3H]spiperone from dopamine receptor D4.4 expressed in CHO-K1 cells
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 16nM
Assay Description:
Displacement of [3H]-spiperone from human D4 receptor expressed in CHO-K1 cells assessed as inhibition constant measured after 60 mins
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 16nM
Assay Description:
In vitro ability to displace [3H]mesulergine binding from 5-hydroxytryptamine 2C receptor from bovine choroid plexus.
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 16nM
Assay Description:
Binding affinity evaluated for the displacement of [3H]spiperone against human dopamine receptor D4
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 16nM
Assay Description:
In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D4 expressed in CHO cells
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Ability to displace [3H]spiperone radioligand from cloned human Dopamine receptor D4 in CHO cells
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
In vitro binding affinity at human cloned dopamine receptor D4 stably expressed in CHO cells by [3H]spiperone displacement.
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Binding affinity against human dopamine receptor D4.4 using radioligand [3H]-spiperone
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Copy BDB DOI
Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
In vitro binding affinity for Dopamine receptor D4
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Ability to displace [3H]-spiperone from cloned human Dopamine receptor D4 expressed in CHO K-1 cells in vitro
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Copy BDB DOI
Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Binding affinity to recombinant human dopamine receptor D4 expressed in CHO cells by displacement of [3H]-spiperone
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Binding affinity of compound towards human cloned Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone as radioligand
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Displacement of [3H]-spiperone from human Dopamine receptor D4.4 expressed in CHO cells
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Competitive binding affinity against human Dopamine receptor D4 by displacing [3H]spiperone from CHO cells
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Copy BDB DOI
Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 17nM
Assay Description:
Displacement of [3H]methylspiperone from human dopamine D4 receptor expressed in CHO cells
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 17nM
Assay Description:
Binding affinity to human cloned 5HT2C receptor
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 17nM
Assay Description:
Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells
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Target
Histamine H1 receptor
(Human)
Intra-Cellular Therapies
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 17nM
Assay Description:
Binding affinity against histamine H1 receptor
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 17nM
Assay Description:
Displacement of [3H]-YM 09151 from D4 receptor
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 17nM
Assay Description:
Compound was tested for the Binding affinity against rat frontal cortex 5-hydroxytryptamine 2A receptor by Radio ligand [3H]-ketanserin binding assay...
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 17nM
Assay Description:
Displacement of [3H]methylspiperone from human recombinant D4 receptor expressed in CHO cells
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 17nM
Assay Description:
Binding affinity at human Dopamine receptor D4 by [3H]- YM 09151 displacement.
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 17nM
Assay Description:
Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]-YM09151-2 from human cloned dopamine D4 receptor expressed in insect Sf9 cells after 60 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding...
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting anal...
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in HEKT cell membranes by radioligand binding assay
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
In vitro binding affinity at human cloned Dopamine receptor D4 expressed in Sf9 cell membranes
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation ...
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Target
Alpha-1A adrenergic receptor
(Human)
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 19nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
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Target
Alpha-2A adrenergic receptor [16-465]
(Rat)
Centro De InvestigacióN Grupo Ferrer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 19nM
Assay Description:
Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]-clonidine binding to rat cortex using unlabeled NAbitartrate f...
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Target
Alpha-1A adrenergic receptor
(Human)
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 19nM
Assay Description:
Inhibition of adrenergic alpha1A receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 20nM
Assay Description:
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 20nM
Assay Description:
Displacement of [3H]-ketanserin from 5HT2A receptor in Wistar rat cortical membrane after 15 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 21nM
Assay Description:
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 21nM
Assay Description:
Displacement of [3H]-ketanserin from 5HT2A receptor in rat brain cortical membranes after 15 mins by liquid scintillation counting
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 21nM
Assay Description:
Affinity was evaluated as inhibition constant for dopamine D-4 receptor
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 21nM
Assay Description:
Inhibition of [3H]-mesulergine binding to human 5-hydroxytryptamine 2C receptor
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 21nM
Assay Description:
Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D4 in COS7 cells
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Target
D(1A) dopamine receptor
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 21.4nM
Assay Description:
Displacement of [3H]SCH23390 from human dopamine D1 receptor
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Target
Alpha-1A adrenergic receptor
(Rat)
Centro De InvestigacióN Grupo Ferrer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 22nM
Assay Description:
Binding affinity measured at the Alpha-1A adrenergic receptor by the inhibition of [3H]-prazosin binding to rat cortex using unlabeled WB-4101 for no...
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Rat)
Universidade Federal Do Rio De Janeiro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 22nM
Assay Description:
Displacement of [3H]-QNB from muscarinic receptor in rat brain cortical membranes after 60 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 23nM
Assay Description:
Displacement of [3H]-mesulergine from human 5HT2C receptor after 60 mins by liquid scintillation counting
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Human)
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 23nM
Assay Description:
Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes)
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Target
5-hydroxytryptamine receptor 2C
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 23nM
Assay Description:
Compound was evaluated for its binding affinity towards rat r5-hydroxytryptamine 2C receptor
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 23nM
Assay Description:
The compound was tested for its binding affinity towards alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortexc
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 24nM
Assay Description:
Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation...
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Target
Alpha-2A adrenergic receptor
(Human)
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 24nM
Assay Description:
Inhibition of [3H]-rauwolscine binding to Alpha-2A adrenergic receptor
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 24nM
Assay Description:
Displacement of [3H]-mesulergine from human 5HT2C receptor after 60 mins by liquid scintillation counting
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Rat)
Universidade Federal Do Rio De Janeiro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 25nM
Assay Description:
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 25nM
Assay Description:
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting anal...
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Target
Alpha-1B adrenergic receptor
(Rat)
Intra-Cellular Therapies
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 25nM
Assay Description:
Displacement of [3H]-prozosin from alpha1B adrenoreceptor in rat liver membranes after 45 mins by liquid scintillation counting
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 28nM
Assay Description:
Ability to displace [3H]spiperone radioligand from cloned human Dopamine receptor D2 in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 28nM
Assay Description:
Displacement of [3H]spiroperidol from human cloned dopamine D2 short receptor expressed in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 28nM
Assay Description:
In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D2 short form expressed in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 28nM
Assay Description:
Competitive binding affinity against human Dopamine receptor D2S by displacing [3H]spiperone from CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 28nM
Assay Description:
Ability of the compound to displace [3H]-spiperone from the cloned human Dopamine receptor D2S stably expressed in Chinese hamster ovary (CHO) cells ...
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 28nM
Assay Description:
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 28nM
Assay Description:
Ability to displace [3H]spiperone radioligand from cloned human Dopamine receptor D2 in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 28nM
Assay Description:
Binding affinity of compound was tested in vitro for its ability to compete with [3H]spiperone radioligand at cloned human Dopamine receptor D2L stab...
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 28nM
Assay Description:
Displacement of [3H]-spiperone from human Dopamine receptor D2L expressed in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 28nM
Assay Description:
Binding affinity against dopamine receptor D2S using radioligand [3H]-spiperone
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 28.4nM
Assay Description:
In vitro ability to inhibit [3H]-spiperone binding to human Dopamine receptor D4.4
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Target
D(4) dopamine receptor
(Rat)
Pharmacia & Upjohn
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 29nM
Assay Description:
Binding affinity of [3H]-YM-09151 towards cloned mammalian Dopamine receptor D4 expressed in cultured cells or from rat whole brain
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Target
Alpha-1B adrenergic receptor
(Rat)
Intra-Cellular Therapies
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 29nM
Assay Description:
Displacement of [3H]-prazosin from alpha1B adrenergic receptor in Wistar rat liver membrane after 45 mins by liquid scintillation counting
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 30nM
Assay Description:
Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 30nM
Assay Description:
Displacement of [3H]-YM-09151-2 (0.06 nM) from human Dopamine receptor D4 expressed in CHO cells
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 30nM
Assay Description:
In vitro binding affinity at human Dopamine receptor D4.4 by [3H]-YM-09151-2 displacement.
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 30.4nM
Assay Description:
In vitro ability to inhibit [3H]-6b binding to human Dopamine receptor D4.4
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 32nM
Assay Description:
In vitro binding affinity for Dopamine receptor D2
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Target
5-hydroxytryptamine receptor 3A
(Mouse)
Yamanouchi Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 32nM
Assay Description:
Compound was tested for the Binding affinity against N1e-115 neuroblastoma 5-hydroxytryptamine 3 receptor by Radio ligand [3H]-GR-65,630 binding assa...
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Target
D(4) dopamine receptor
(Rat)
Pharmacia & Upjohn
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 32nM
Assay Description:
Binding affinity of [3H]-Spiperone towards Dopamine receptor D4 expressed in cultured cells or from rat whole brain.
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 33nM
Assay Description:
Displacement of [3H]-ketanserin from human 5-HT2A receptor expressed in CHO-K1 cells measured after 1.5 hrs by Microbeta plate reader method
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Human)
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 34nM
Assay Description:
Binding affinity towards human muscarinic receptor
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 34nM
Assay Description:
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 34nM
Assay Description:
In vitro Dopamine receptor D2 affinity by using [3H]-Spiperone as the radioligand in rat limbic system at 1 uM concentration of compound
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 36nM
Assay Description:
Binding affinity measured at the Dopamine receptor D4 by the inhibition of [3H]-spiperone binding to human recombinant CHO cells using unlabeled halo...
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 36nM
Assay Description:
Displacement of [3H]ketanserin from human 5HT2A receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysis
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 37nM
Assay Description:
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 39nM
Assay Description:
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 radioligand in rat hippocampus
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 39nM
Assay Description:
Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]WB-4101
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 39nM
Assay Description:
Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligand
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 39nM
Assay Description:
Ability of the compound to displace [3H]-spiperone from the cloned human Dopamine receptor D2L stably expressed in Chinese hamster ovary (CHO) cells ...
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 39nM
Assay Description:
In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D2L stably expressed in CHO cells
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 39nM
Assay Description:
Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 40nM
Assay Description:
Inhibition of human dopamine D4 receptor
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 40nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D4.4 receptor expressed in CHO cells
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 40nM
Assay Description:
Binding affinity towards human dopamine-4.2 receptor
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 40nM
Assay Description:
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 40nM
Assay Description:
Binding affinity towards human dopamine receptor D4
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 41nM
Assay Description:
Binding affinity to human D2R assessed as inhibition constant
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 41nM
Assay Description:
Displacement of [3H]SCH23390 from human cloned dopamine D2 long receptor expressed in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 41nM
Assay Description:
In vitro binding affinity at human cloned dopamine receptor D2 (long) stably expressed in CHO cells by [3H]-Spiperone displacement.
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 41nM
Assay Description:
Binding affinity against dopamine receptor D2L using radioligand [3H]-spiperone
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Copy BDB DOI
Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 41nM
Assay Description:
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 41nM
Assay Description:
Displacement of [3H]-spiperone from human Dopamine receptor D2L expressed in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Copy InChI
Affinity Data
Ki: 41nM
Assay Description:
Displacement of [3H]spiperone from human Dopamine receptor D2L expressed in CHO cells
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Target
5-hydroxytryptamine receptor 2C
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 42nM
Assay Description:
Displacement of [3H]mesulergine from 5-HT2C receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 43nM
Assay Description:
Affinity of the compound was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand
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Target
D(1A) dopamine receptor
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 44nM
Assay Description:
Binding affinity to human dopamine D1 receptor
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Copy BDB DOI
Target
D(1A) dopamine receptor
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 44nM
Assay Description:
Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 45nM
Assay Description:
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 46nM
Assay Description:
Binding affinity against dopamine D2 receptor
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Target
Muscarinic acetylcholine receptor M2
(Rat)
Yamanouchi Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 46nM
Assay Description:
Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]-quinuclidinyl binding assay.
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 46nM
Assay Description:
Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 46nM
Assay Description:
Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 47nM
Assay Description:
Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting me...
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 47nM
Assay Description:
In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 48nM
Assay Description:
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 48nM
Assay Description:
Inhibition of [3H]-5-HT binding to human 5-hydroxytryptamine 7 receptor
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 48nM
Assay Description:
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method
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Target
5-hydroxytryptamine receptor 3A/3B
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 53nM
Assay Description:
Affinity of the compound was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 3 receptor
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Target
D(1A) dopamine receptor
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 53nM
Assay Description:
Binding affinity against dopamine receptor D1
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Target
Muscarinic acetylcholine receptor M1
(Rat)
Yamanouchi Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 54nM
Assay Description:
In vitro binding affinity towards M1 receptor of rat frontal cortex homogenate by using radioligand [3H]QNB
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 54nM
Assay Description:
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 54nM
Assay Description:
Binding affinity was determined against Dopamine receptor D2 using [3H]spiperone
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 54nM
Assay Description:
Binding affinity to human cloned dopamine D4 receptor
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 54nM
Assay Description:
In vitro ability to inhibit the binding of [3H]spiperone to cloned human dopamine receptor D4 using apomorphine induced climbing test in male Swiss m...
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 54nM
Assay Description:
In vitro ability to inhibit the binding of [3H]-spiperone to cloned human dopamine receptor D4 using apomorphine induced climbing test in male Swiss ...
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 54nM
Assay Description:
Binding affinity was determined against Dopamine receptor D2 using [3H]spiperone
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Target
Muscarinic acetylcholine receptor M1
(Rat)
Yamanouchi Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 55nM
Assay Description:
Half-maximal inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor M1 in rat frontal cortex homogenate
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D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 55nM
Assay Description:
radioligand binding assay.
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 60nM
Assay Description:
Displacement of [3H]-YM-09151-2 from human D4 dopamine receptor after 120 mins by liquid scintillation counting
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 60nM
Assay Description:
Displacement of [3H]-YM-09151-2 from human D4 receptor after 120 mins by liquid scintillation counting
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Target
Serotonin 2 (5-HT2) receptor
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 60nM
Assay Description:
Compound was evaluated for in vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat cortex using [3H]- spiperone as radioligand
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Target
5-hydroxytryptamine receptor 7
(Rat)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 63nM
Assay Description:
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 63nM
Assay Description:
Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D2 trunk/D2 tail receptor transfected in african green monkey COS7 cel...
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 64nM
Assay Description:
Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D2 receptor transfected in african green monkey COS7 cells after 1 hr...
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 69nM
Assay Description:
Binding affinity for dopamine receptor D2 determined using [3H]-spiperone
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 70nM
Assay Description:
Binding affinity on human Dopamine receptor D4 expressed in CHO cells using radioligand [3H]-YM 09151
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 71nM
Assay Description:
Displacement of [3H]-YM 09151 from human Dopamine receptor D4
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 71nM
Assay Description:
Displacement of [3H]-raclopride from human D2LR expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 72nM
Assay Description:
Binding affinity to human dopamine D2L receptor expressed in HEK293 cells after 1 hr
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 72nM
Assay Description:
Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptor
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 73nM
Assay Description:
Antagonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular calcium release measured fo...
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 74nM
Assay Description:
Binding affinity towards cloned human Dopamine receptor D2 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligand
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Copy BDB DOI
Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 74nM
Assay Description:
Displacement of [3H]-spiperone from human Dopamine receptor D2 expressed in CHO cells
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Copy BDB DOI
Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 74nM
Assay Description:
Displacement of [3H]-spiperone from human Dopamine receptor D2 expressed in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 74nM
Assay Description:
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D2 stably expressed in CHO cell lines
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 74nM
Assay Description:
Ability to displace [3H]-spiperone from human dopamine receptor D2 stably expressed in CHO cells.
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(Rat)
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 79nM
Assay Description:
Displacement of [3H]RX 821002 from adrenergic alpha-2 receptor in rat cerebral cortex
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 82nM
Assay Description:
Binding affinity against Dopamine receptor D2 from rat striatum
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 82nM
Assay Description:
Binding affinity towards dopamine D2 receptors in rat brain synaptosomal preparations
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 82nM
Assay Description:
Binding affinity of [3H]-YM-09151 towards cloned mammalian Dopamine receptor D2 expressed in cultured cells or from rat whole brain
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 83nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 83nM
Assay Description:
Displacement of [3H]-NPA from rat brain Dopamine receptor D2
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 88nM
Assay Description:
Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells
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Target
D(1A) dopamine receptor
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 89nM
Assay Description:
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 89nM
Assay Description:
Displacement of [3H]spiperone from wild-type human dopamine D2S receptor expressed in CHO-K1 cell membrane after 2 hrs by beta counting
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 89.1nM
Assay Description:
Displacement of [3H]spiperone from wild-type human dopamine D2S receptor expressed in CHO-K1 cell membrane after 2 hrs by beta counting
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 91nM
Assay Description:
Ability to displace [3H]-spiperone from human cloned Dopamine receptor D2 expressed in CHO K-1 cells in vitro.
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 91nM
Assay Description:
Binding affinity against cloned human dopamine receptor D2 expressed in Chinese hamster ovary (CHO) K-1 cells by displacement of [3H]-spiperone.
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 93nM
Assay Description:
Binding affinity measured at the Dopamine receptor D2 by the inhibition of [3H]-methylspiperone binding to rat striatum using unlabeled haloperidol f...
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 95nM
Assay Description:
Binding affinity at 5HT1A receptor in rat striatal membranes
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 100nM
Assay Description:
Tested in vitro for its ability to inhibit [3H]spiperone binding to Dopamine receptor D2 in rat striatal membrane
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(Rat)
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 100nM
Assay Description:
Displacement of [3H]-RX821002 from alpha2 adrenoreceptor in rat brain cortical membranes after 45 mins by liquid scintillation counting
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 100nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 100nM
Assay Description:
Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: >100nM
Assay Description:
Binding affinity to dopamine D2 receptor (unknown origin) by radioligand binding assay
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Target
Alpha-2A adrenergic receptor [16-465]
(Rat)
Centro De InvestigacióN Grupo Ferrer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 100nM
Assay Description:
Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 101nM
Assay Description:
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 102nM
Assay Description:
Displacement of [3H]-spiperone from human dopamine D2L receptor expressed in CHO FlpIn cell membrane measured after 60 mins by topcount scintillation...
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 106nM
Assay Description:
Displacement of [3H]-spiperone from human dopamine D2L receptor expressed in CHO FlpIn cell membrane measured after 60 mins by topcount scintillation...
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 111nM
Assay Description:
Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortex
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 111nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 1A receptor of rat brain synaptosomal preparations
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 113nM
Assay Description:
Binding affinity at human Dopamine receptor D2 by [3H]- YM 09151 displacement.
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 113nM
Assay Description:
Displacement of [3H]-YM 09151 from D2 receptor
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 115nM
Assay Description:
Binding affinity against dopamine receptor D1
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 115nM
Assay Description:
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 117nM
Assay Description:
Displacement of [3H]-spiperone from Dopamine receptor D2 of rat corpora striata synaptic membranes
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 118nM
Assay Description:
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound; value may ra...
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 126nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cells
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(Rat)
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 128nM
Assay Description:
In vitro binding affinity towards alpha-2 adrenergic receptor in rat frontal cortex homogenate using of [3H]clonidine as radioligand
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 130nM
Assay Description:
Displacement of [3H]spiperone from dopamine D2 receptor in rat straitum tissue after 20 mins by scintillation counting
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 130nM
Assay Description:
Binding affinity to human dopamine D2 receptor
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 130nM
Assay Description:
Binding affinity to human cloned dopamine D2 receptor
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 130nM
Assay Description:
Compound was tested for the Binding affinity against rat hippocampal 5-hydroxytryptamine 1A receptor by Radio ligand [3H]-8-OH-DPAT binding assay.
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 130nM
Assay Description:
In vitro ability to inhibit the binding of [3H]-spiperone to cloned human Dopamine receptor D2 using apomorphine induced climbing test in male Swiss ...
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 130nM
Assay Description:
Displacement of [3H]-YM-09151-2 from D2 dopamine receptor in Wistar rat brain striatal membrane after 60 mins by liquid scintillation counting
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 130nM
Assay Description:
Inhibition of D2 receptor (unknown origin)
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Target
D(1A) dopamine receptor
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 132nM
Assay Description:
Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells
Checked by Author
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Target
D(1A) dopamine receptor
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 132nM
Assay Description:
Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 135nM
Assay Description:
Cataleptogenic effect against cloned human Dopamine receptor D2 in male Sprague-Dawley rats in a bar test
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 138nM
Assay Description:
Binding affinity of [3H]-spiperone towards cloned mammalian Dopamine receptor D2 expressed in cultured cells or from rat whole brain
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 138nM
Assay Description:
Binding affinity towards human dopamine D2 receptor, using [3H]-YM-09151 as a radioligand
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 138nM
Assay Description:
Binding affinity towards Dopamine receptor D2 was determined via standard competitive displacement assays using [3H]-YM 09151 as the competitive liga...
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 138nM
Assay Description:
Binding affinity of [3H]-spiperone towards cloned mammalian Dopamine receptor D2 expressed in cultured cells or from rat whole brain
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 140nM
Assay Description:
Displacement of [3H]-YM-09151-2 from D2 receptor in rat brain striatal membranes after 60 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 140nM
Assay Description:
Displacement of [3H]8OH-DPAT from 5HT1A in rat brain cerebral cortex after 15 mins by scintillation counting
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 140nM
Assay Description:
Inhibition of human 5HT1A receptor
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 140nM
Assay Description:
Binding affinity to human cloned 5HT1A receptor
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 143nM
Assay Description:
Displacement of [3H]-8-OH-DPAT from human 5-HT1AR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 143nM
Assay Description:
Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 143nM
Assay Description:
Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 144nM
Assay Description:
Inhibition of [3H]-spiperone binding to human Dopamine receptor D2
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 145nM
Assay Description:
Binding affinity at dopamine D2 receptor in rat striatal membranes
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 150nM
Assay Description:
Displacement of [3H]-raclopride from human D2L receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 150nM
Assay Description:
Binding affinity of [3H]-8-OH-DPAT towards 5-hydroxytryptamine 1A receptor in cloned mammalian receptor expressed in cultured cells or from rat whole...
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 150nM
Assay Description:
Binding affinity towards human Dopamine receptor D2
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 155nM
Assay Description:
In vitro binding affinity against human D2 dopamine receptor in CHO cells by [3H]-spiperone displacement.
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 155nM
Assay Description:
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 157nM
Assay Description:
Antagonist activity at D2 receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 160nM
Assay Description:
Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometry
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 160nM
Assay Description:
Binding affinity to 5HT1A receptor (unknown origin)
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Target
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Human)
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 160nM
Assay Description:
In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 160nM
Assay Description:
Displacement of [3H]8OH-DPAT from 5HT1A receptor in rat CRL:CD(SD)BR-COBS hippocampus by scintillation spectrometry
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Target
D(3) dopamine receptor
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 161nM
Assay Description:
Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr...
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 161nM
Assay Description:
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 168nM
Assay Description:
In vitro binding affinity towards dopamine receptor D2 in rat striatal membranes by [3H]-sulpiride displacement.
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 170nM
Assay Description:
In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 170nM
Assay Description:
Binding affinity of [3H]-SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 180nM
Assay Description:
Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
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Target
D(1A) dopamine receptor
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 180nM
Assay Description:
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]-SCH-23390) binding assay
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Target
Alpha-2A adrenergic receptor
(Human)
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 185nM
Assay Description:
Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation cou...
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Target
5-hydroxytryptamine receptor 3A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 186nM
Assay Description:
Binding affinity to 5-HT3 receptor (unknown origin)
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Target
D(3) dopamine receptor
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 188nM
Assay Description:
Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D3 tail receptor transfected in african green monkey COS7 cel...
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D(2) dopamine receptor
(Human)
Florida A and M University
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ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 190nM
Assay Description:
Binding affinity towards human D2 dopamine receptor.
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 190nM
Assay Description:
Displacement of [3H]-N-methylspiperone from rat recombinant dopamine D2 short receptor expressed in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 190nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
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Target
D(1B) dopamine receptor
(Human)
Johann Wolfgang Goethe Universit£T
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 198nM
Assay Description:
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 200nM
Assay Description:
Ability to displace [3H]-spiperone from human dopamine receptor D3 (hD3) receptor stably expressed in HEK-293 cells.
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 200nM
Assay Description:
Displacement of [3H]-spiperone from human Dopamine receptor D3 expressed in HEK-293 cells
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Target
Histamine H4 receptor
(Human)
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 200nM
Assay Description:
Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 200nM
Assay Description:
compound was tested for its affinity to displace [3H]-spiperone cloned human Dopamine receptor D3 stably expressed in HEK-393 cell lines
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 200nM
Assay Description:
Binding affinity towards cloned human Dopamine receptor D3 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligand
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 200nM
Assay Description:
Displacement of [3H]-spiperone from human Dopamine receptor D3 expressed in CHO cells
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 208nM
Assay Description:
Displacement of [3H]methylspiperone from dopamine D2 receptor expressed in CHO cells
Checked by Author
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 208nM
Assay Description:
Displacement of [3H]methylspiperone from human dopamine D2 receptor expressed in CHO cells
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 210nM
Assay Description:
Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 210nM
Assay Description:
The binding affinity was measured on serotonin 5-hydroxytryptamine 1 receptor in rat brain tissue
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 210nM
Assay Description:
Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 210nM
Assay Description:
Binding affinity to dopamine D2 receptor (unknown origin)
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 220nM
Assay Description:
Affinity was evaluated as inhibition constant for dopamine D-2 receptor
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 220nM
Assay Description:
Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D2L in COS7 cells
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 222nM
Assay Description:
Binding affinity against cloned human dopamine receptor D3 expressed in Chinese hamster ovary (CHO) K-1 cells by displacement of [3H]-spiperone.
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 222nM
Assay Description:
Ability to displace [3H]-spiperone from human cloned Dopamine receptor D3 expressed in CHO K-1 cells in vitro.
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 224nM
Assay Description:
Displacement of [3H]spiperone from human cloned dopamine D2 receptor
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 224nM
Assay Description:
Displacement of [3H]spiperone from human cloned dopamine D2 receptor
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 224nM
Assay Description:
Displacement of [3H]spiperone human cloned dopamine D2 receptor
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 224nM
Assay Description:
Binding affinity towards dopamine receptor D2
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Copy BDB DOI
Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 224nM
Assay Description:
Displacement of [3H]spiperone from human D2 receptor
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 230nM
Assay Description:
Binding affinity to human 5HT2A receptor
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Target
D(3) dopamine receptor
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 230nM
Assay Description:
Binding affinity of the compound to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligand
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 235nM
Assay Description:
Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]-SCH-23,390 binding to rat striatum using unlabeled apomorphine for no...
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 240nM
Assay Description:
Binding affinity to human cloned dopamine D3 receptor
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 240nM
Assay Description:
Cataleptogenic effect against cloned human Dopamine receptor D3 in male Sprague-Dawley rats in a bar test
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 240nM
Assay Description:
In vitro ability to inhibit the binding of [3H]-7-OH-DPAT to cloned human Dopamine receptor D3 using apomorphine induced climbing test in male Swiss ...
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 242nM
Assay Description:
Inhibition of [125I]-iodosulpride binding to human Dopamine receptor D3
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 247nM
Assay Description:
Binding affinity measured at the 5-hydroxytryptamine 1A receptor by the inhibition of [3H]-8-OH-DPAT binding to rat cortex using unlabeled buspirone ...
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 250nM
Assay Description:
Binding affinity which represents concentration giving half-maximal inhibition of [3H]spiperone (Dopamine receptor D2) binding to rat tissue homogena...
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 250nM
Assay Description:
Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenate
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 250nM
Assay Description:
Inhibition of [3H]-spiperone binding to rat dopamine D2 receptor
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 250nM
Assay Description:
Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptor
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 250nM
Assay Description:
In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligand
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 254nM
Assay Description:
Binding affinity on human Dopamine receptor D2 expressed in CHO cells using radioligand [3H]-YM 09151
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Target
D(2) dopamine receptor
(Green monkey)
Neurogen
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 254nM
Assay Description:
Displacement of [3H]-YM 09151 from african green monkey Dopamine receptor D2
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Target
D(2) dopamine receptor
(Green monkey)
Neurogen
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 254nM
Assay Description:
Displacement of [3H]YM-09151 from recombinant African green monkey Dopamine receptor D2
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 260nM
Assay Description:
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in rat brain hippocampal membranes after 15 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 260nM
Assay Description:
Displacement of [3H]-OH-8-DPAT from 5HT1A receptor in Wistar rat hippocampal membrane after 15 mins by liquid scintillation counting
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 260nM
Assay Description:
Binding affinity to rat Dopamine receptor D2 expressesd in CHO cells was determined using [125 I ] iodosulpride as radioligand
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 260nM
Assay Description:
In vitro binding affinity towards Dopamine receptor D2 in human using [3H]-spiperone as radioligand
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 263nM
Assay Description:
In vitro ability to displace [3H]spiperone binding from dopamine receptor D2 in rat striatal membrane.
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 263nM
Assay Description:
Compound was measured for the inhibition of [3H]spiperone binding to striatal membrane Dopamine receptor D2
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 270nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligand
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Target
D(3) dopamine receptor
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 280nM
Assay Description:
Binding affinity of the compound to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligand
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 280nM
Assay Description:
Binding affinity towards human dopamine receptor D3
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Target
D(1A) dopamine receptor
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 290nM
Assay Description:
Binding affinity to human cloned dopamine D1 receptor
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 295nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells
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Target
D(3) dopamine receptor
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 319nM
Assay Description:
In vitro binding affinity towards Dopamine receptor D3 in Sf9 cell membranes using [3H]7-OH-DPAT as radioligand
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 319nM
Assay Description:
Binding affinity to dopamine D3 receptor (unknown origin)
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 319nM
Assay Description:
Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 319nM
Assay Description:
Displacement of [3H]7OH-DPAT from dopamine D3 receptor (unknown origin) expressed in Sf9 cells by scintillation spectrometry
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
Ki: 319nM
Assay Description:
Inhibition of [3H]-7-OH-DPAT binding to Dopamine D3 receptor expressed in Sf9 cells
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Target
D(3) dopamine receptor
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 320nM
Assay Description:
Half-maximal inhibition of [3H]-7-OH-DPAT binding to Dopamine receptor D3 in rat tissue homogenate
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Target
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 320nM
Assay Description:
In vitro ability to displace [3H]spiroperidol from rat dopamine receptor
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 350nM
Assay Description:
Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 353nM
Assay Description:
Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 353nM
Assay Description:
Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 353nM
Assay Description:
In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 353nM
Assay Description:
Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogena...
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 359nM
Assay Description:
Binding affinity of the compound to the dopamine receptor D2L in rat brain membranes
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 360nM
Assay Description:
Binding affinity towards human Dopamine receptor D3
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
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ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 372nM
Assay Description:
In vitro binding affinity at human cloned Dopamine receptor D2L expressed in Sf9 cell membranes
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 372nM
Assay Description:
Binding affinity to dopamine D3 receptor
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 380nM
Assay Description:
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 389nM
Assay Description:
Antagonist activity at human D2 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 389nM
Assay Description:
Binding affinity to human dopamine D2 receptor
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Target
Transporter
(Rat)
Florida A&M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 390nM
Assay Description:
Binding affinity to rat NET
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 415nM
Assay Description:
The compound was tested binding affinity against 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligand at 10e-6 M.
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Target
D(1A) dopamine receptor
(Pig)
University of Tours
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 420nM
Assay Description:
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane
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Target
D(1A) dopamine receptor
(Bovine)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 420nM
Assay Description:
Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390
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Target
D(1A) dopamine receptor
(Bovine)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 420nM
Assay Description:
Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes
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Target
D(1A) dopamine receptor
(Bovine)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 420nM
Assay Description:
In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.
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Target
D(1A) dopamine receptor
(Bovine)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 420nM
Assay Description:
Displacement of [3H]-SCH-23,390 from bovine striatal membrane Dopamine receptor D1
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Target
D(1A) dopamine receptor
(Bovine)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 420nM
Assay Description:
Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1
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Target
D(1A) dopamine receptor
(Bovine)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 420nM
Assay Description:
Displacement of [3H]SCH23390 from bovine dopamine D1 receptor
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Target
D(1A) dopamine receptor
(Bovine)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 420nM
Assay Description:
In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane
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Target
D(1A) dopamine receptor
(Bovine)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 420nM
Assay Description:
Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1
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Target
D(1A) dopamine receptor
(Bovine)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 420nM
Assay Description:
Ability of the compound to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 443nM
Assay Description:
In vitro binding affinity towards 5-hydroxytryptamine receptor 1A receptor by using [3H]-8-OH-DPAT in rat hippocampal membranes.
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 454nM
Assay Description:
Binding affinity on human Dopamine receptor D3 expressed in CHO cells using radioligand [3H]-YM 09151
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Target
D(3) dopamine receptor
(Green monkey)
Neurogen
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 466nM
Assay Description:
Displacement of [3H]-YM 09151 from african moonkey Dopamine receptor D3
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Target
D(3) dopamine receptor
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 500nM
Assay Description:
Binding affinity towards baculovirus expressed rat dopamine D3 receptors
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 513nM
Assay Description:
Binding affinity measured at the Dopamine receptor D3 by the inhibition of [3H]-YM-09151-2 binding to human recombinant CCL 1.3 cells using unlabeled...
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 539nM
Assay Description:
Inhibition of [3H]-SCH-23,390 binding to rat Dopamine receptor D1
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Target
D(1A) dopamine receptor
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 540nM
Assay Description:
Binding affinity towards human Dopamine receptor D1
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 550nM
Assay Description:
The D2 binding Ki values were determined using a radioligand binding assay.
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Target
Histamine H3 receptor
(Human)
Novo Nordisk
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 631nM
Assay Description:
Antagonist potency against human H3 receptor in GTPgamma[S]-Assay
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 640nM
Assay Description:
Compound was evaluated for in vitro binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]-8-OH-DPAT as radioligand
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Target
D(2) dopamine receptor
(Bovine)
Universit£T Erlangen-N£Rnberg
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 690nM
Assay Description:
Binding affinity was evaluated for the displacement of [3H]spiperone against bovine Dopamine receptor D2
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Target
Transporter
(Rat)
Johnson & Johnson Pharmaceutical Research & Development
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ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 697nM
Assay Description:
Inhibition of [3H]-nisoxetine binding to rat Norepinephrine transpoter
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 710nM
Assay Description:
Binding affinity towards human 5-hydroxytryptamine 1 receptor
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Target
D(1B) dopamine receptor
(Human)
Johann Wolfgang Goethe Universit£T
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 780nM
Assay Description:
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]-SCH-23390) binding assay
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 790nM
Assay Description:
Compound was evaluated for in vitro binding affinity towards Dopamine receptor D2 in rat striatum using [3H]- spiperone as radioligand
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 876nM
Assay Description:
In vitro binding affinity towards Dopamine receptor D2L, using [3H]-spiroperidol radioligand in Sf9 baculovirus expression.
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 912nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D3 receptor
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 960nM
Assay Description:
Competitive binding affinity against human Dopamine receptor D3 by displacing [3H]spiperone from CHO cells
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 960nM
Assay Description:
Ability of the compound to displace [3H]-spiperone from the cloned human D3 dopamine receptor stably expressed in Chinese hamster ovary (CHO) cells w...
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 960nM
Assay Description:
In vitro binding affinity at human cloned dopamine receptor D3 stably expressed in CHO cells by [3H]spiperone displacement.
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 960nM
Assay Description:
Ability to displace [3H]spiperone radioligand from cloned human Dopamine receptor D3 in CHO cells
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 960nM
Assay Description:
In vitro displacement of [3H]spiperone from the cloned human dopamine receptor D3 stably expressed in CHO cells
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 960nM
Assay Description:
Binding affinity evaluated for the displacement of [3H]-spiperone against human dopamine receptor D3
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Target
D(3) dopamine receptor
(Human)
University of Camerino
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 960nM
Assay Description:
Displacement of [3H]-spiperone from human D3 receptor assessed as inhibition constant
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 960nM
Assay Description:
Displacement of [3H]spiroperidol from human cloned dopamine D3 receptor expressed in CHO cells
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 960nM
Assay Description:
Binding affinity against dopamine receptor D3 using radioligand [3H]-spiperone
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 960nM
Assay Description:
Displacement of [3H]-spiperone from human Dopamine receptor D3 expressed in CHO cells
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 960nM
Assay Description:
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane
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Target
5-hydroxytryptamine receptor 5A
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1.00E+3nM
Assay Description:
Binding affinity towards human 5-hydroxytryptamine 5A receptor was evaluated using [3H]-5-CT as radioligand
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Target
Histamine H3 receptor
(Human)
Novo Nordisk
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells
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Target
Sodium-dependent serotonin transporter
(Human)
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 3.08E+3nM
Assay Description:
Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA
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Target
Sodium-dependent serotonin transporter
(Human)
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 3.90E+3nM
Assay Description:
Binding affinity to human SERT
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 4.06E+3nM
Assay Description:
Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay
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Target
Aldehyde oxidase
(Human)
Washington State University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 5.10E+3nM
Assay Description:
Competitive inhibition of human liver cytosolic aldehyde oxidase using DACA as substrate assessed as free enzyme by Lineweaver-Burk plot analysis
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Target
Sigma non-opioid intracellular receptor 1
(Human)
Centro De InvestigacióN Grupo Ferrer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 8.50E+3nM
Assay Description:
Binding affinity measured at the sigma receptor by the inhibition of [3H]-3-PPP binding to guinea pig cerebellum using unlabeled 3-PPP for nonspecifi...
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Target
Sigma non-opioid intracellular receptor 1
(Human)
Centro De InvestigacióN Grupo Ferrer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 8.50E+3nM
Assay Description:
Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brain
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 9.00E+3nM
Assay Description:
Binding affinity towards Dopamine Receptor D4 was determined via standard competitive displacement assays using [3H]-YM 09151 as the competitive liga...
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Target
5-hydroxytryptamine receptor 7
(Human)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1.70E+4nM
Assay Description:
Binding affinity to human ERG expressed in HEK293 cells
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 1.70E+4nM
Assay Description:
Binding affinity to human ERG expressed in HEK293 cells by whole cell patch clamp method
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Target
Beta-1 adrenergic receptor
(Rat)
Centro De InvestigacióN Grupo Ferrer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Ki: 2.60E+4nM
Assay Description:
Binding affinity measured at the Beta-1 adrenergic receptor by the inhibition of [3H]-DHA binding to rat cortex using unlabeled isoprenalin for nonsp...
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Target
Adenylate cyclase type 1
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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IC50: 1.40nM
Assay Description:
Inhibition of dopamine-sensitive rat brain adenylyl cyclase activity assessed as cAMP level
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Target
5-hydroxytryptamine receptor 2A
(Bovine)
Institut De Chimie Pharmaceutique Albert Lespagnol
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 3nM
Assay Description:
Affinity towards 5-hydroxytryptamine 2A receptor in membranes from bovine frontal cortex using [3H]-Ketanserin
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 7.80nM
Assay Description:
Inhibition of [3H]-ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brain
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Target
Serotonin 2 (5-HT2) receptor
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 7.80nM
Assay Description:
Inhibition of [3H]ketanserin binding to dopamine 5-hydroxytryptamine 2 receptor
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 7.80nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 2A receptor, activity is expressed as IC50 values.
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Target
Histamine H1 receptor
(Rat)
University of Siena
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 9nM
Assay Description:
Displacement of [3H]mepyramine from H1R in rat brain
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 9nM
Assay Description:
Inhibition constant against dopamine receptor D2
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Target
Muscarinic acetylcholine receptor M1
(Human)
Merck Sharp and Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 9.40nM
Assay Description:
Inhibition of binding of 1.0 nM [3H]-pirenzepine to cloned human Muscarinic acetylcholine receptor M1 expressed in membranes from CHO-K1 cells
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Target
Muscarinic acetylcholine receptor M1
(Human)
Merck Sharp and Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 9.40nM
Assay Description:
Inhibitory binding of [3H]-pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cells
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Target
5-hydroxytryptamine receptor 2C
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 10nM
Assay Description:
Affinity towards 5-hydroxytryptamine 2C receptor in membranes from pig choroid plexus using [3H]-N-methyl-mesulergine
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Target
5-hydroxytryptamine receptor 2C
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 11nM
Assay Description:
Inhibition of [3H]-mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranes
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Target
5-hydroxytryptamine receptor 2C
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 11nM
Assay Description:
Binding affinity towards 5-HT2C receptor from rat using [3H]-mesulergine as radioligand
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Rat)
Universidade Federal Do Rio De Janeiro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 12nM
Assay Description:
Concentration required (in vitro) to displace 50% specific binding of [3H]clozapine to Muscarinic acetylcholine receptor in rat brain
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Rat)
Universidade Federal Do Rio De Janeiro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 12nM
Assay Description:
Tested in vitro for its ability to displace 3[H] clozapine from Muscarinic acetylcholine receptor in rat brain
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 12nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 2A receptor from rat frontal cortex using [3H]-ketanserin as radioligand
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Target
5-hydroxytryptamine receptor 2A
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 12nM
Assay Description:
Inhibitory concentration against human 5-HT2A receptor in BEK cells
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 13nM
Assay Description:
Inhibition of [3H]-ketanserin binding to rat frontal cortex membrane 5-hydroxytryptamine 2A receptor
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 17nM
Assay Description:
Binding affinity to dopamine receptor D4 cloned from human, using [3H]- YM09151 as competitive ligand
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 17nM
Assay Description:
Displacement of [3H]LSD from human cloned 5-HT6 receptor expressed in HeLa cells
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Target
Serotonin 2 (5-HT2) receptor
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 20nM
Assay Description:
Binding affinity against serotonin-2 receptor in rat brain using [3H]spiroperidol
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Rat)
Universidade Federal Do Rio De Janeiro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 20nM
Assay Description:
Binding affinity against Muscarinic acetylcholine receptor in rat brain using [3H]- QNB
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 20nM
Assay Description:
The compound was tested for inhibition of [3H]WB-4101 binding to alpha-1 adrenergic receptor of rat frontal cortex
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 20nM
Assay Description:
Antagonist activity at human 5HT6 receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 d...
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Target
5-hydroxytryptamine receptor 6
(Human)
City University of New York
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 20nM
Assay Description:
Antagonist activity at serotonin human 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 min...
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Target
Serotonin 2 (5-HT2) receptor
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 21nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 2 receptor measured using radioligand ([3H]spiperone) binding assay
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Target
Serotonin 2 (5-HT2) receptor
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 21nM
Assay Description:
Ability to bind at 5-hydroxytryptamine 2 receptor of rat hippocampus by displacing [3H]spiperone
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 23nM
Assay Description:
In vitro binding affinity at human cloned Dopamine receptor D4.2 by [3H]-YM-09151-2 displacement.
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Target
Histamine H1 receptor
(Rat)
University of Siena
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 23nM
Assay Description:
Inhibitory binding of [3H]-mepyramine to histamine H1 receptors in rat brain membranes
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Target
Histamine H1 receptor
(Rat)
University of Siena
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 23nM
Assay Description:
Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]-mepyramine as radioligand
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Target
Serotonin 2 (5-HT2) receptor
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 30nM
Assay Description:
Compound was measured for affinity at 5-hydroxytryptamine 2 receptor in rat cortical by [3H]spiroperidol displacement.
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Target
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 30nM
Assay Description:
Binding affinity against dopamine receptor in rat striatal membrane using [3H]haloperidol
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 38nM
Assay Description:
In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(Rat)
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 40nM
Assay Description:
Binding affinity against alpha-2 adrenergic receptor in rat brain using [3H]- clonidine
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 40nM
Assay Description:
Binding affinity against alpha-1 adrenergic receptor in rat brain using [3H]- WB-4101
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Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 40.7nM
Assay Description:
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 41nM
Assay Description:
Displacement of [3H]methylspiperone from human recombinant Dopamine D4.4 receptor expressed in CHO cells
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Rat)
Universidade Federal Do Rio De Janeiro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 48nM
Assay Description:
The compound was tested for inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Rat)
Universidade Federal Do Rio De Janeiro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 51nM
Assay Description:
Binding affinity was determined against Muscarinic acetylcholine receptor using [3H]QNB as radioligand in rat brain.
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Rat)
Universidade Federal Do Rio De Janeiro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 51nM
Assay Description:
Binding activity against muscarinic receptor in rat brain using [3H]QNB as the radioligand
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 52nM
Assay Description:
Binding affinity towards human D4.2 receptor
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Copy BDB DOI
Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 58nM
Assay Description:
Inhibitory concentration against human Dopamine receptor D4.2 in CHO cells
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Target
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 60nM
Assay Description:
Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenate
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Target
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 61nM
Assay Description:
Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 62nM
Assay Description:
Ability to inhibit [3H]WB-4101 binding to rat cortical alpha-1-adrenergic receptor
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Copy BDB DOI
Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
IC50: 62nM
Assay Description:
In vitro inhibitory concentration against radioligand [3H]WB-4101 binding to rat cortical alpha-1 adrenergic receptor
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Copy BDB DOI
Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
IC50: 62nM
Assay Description:
In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101
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Copy BDB DOI
Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
IC50: 62nM
Assay Description:
Ability to bind at Alpha-1 adrenergic receptor by displacing [3H]WB-4101
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rat)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 72nM
Assay Description:
In vitro affinity towards 5-hydroxytryptamine 2A receptor using [3H]-spiroperidol as radioligand in cortex
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 113nM
Assay Description:
Binding affinity to dopamine receptor D2 cloned from human, using [3H]- YM09151 as competitive ligand
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Copy BDB DOI
Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rat)
Combichem
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 125nM
Assay Description:
Inhibition of specific [3H]-prazosin binding (0.2 nM) to rat brain membranes alpha1 adrenoceptor.
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 130nM
Assay Description:
Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]-SCH-23,390 as radioligand
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 130nM
Assay Description:
Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 130nM
Assay Description:
Inhibition of [3H]-methylspiperone binding to rat striatal membrane Dopamine receptor D2
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
IC50: 130nM
Assay Description:
Inhibitory binding of [3H]-SCH-23,390 to Dopamine receptor D1 in membranes from rat corpus striatum
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 132nM
Assay Description:
Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 138nM
Assay Description:
Inhibitory concentration against dopamine receptor D4
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Copy BDB DOI
Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 140nM
Assay Description:
Antagonist activity at D2L receptor (unknown origin) expressed in human HTLA cells assessed as inhibition of dopamine-stimulated beta-arrestin2 recru...
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Target
D(2) dopamine receptor
(Bovine)
Universit£T Erlangen-N£Rnberg
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 140nM
Assay Description:
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride
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Target
5-hydroxytryptamine receptor 1A
(Human)
TBA
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 150nM
Assay Description:
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]-OH-DPAT
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 156nM
Assay Description:
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
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Target
Alpha-1A adrenergic receptor
(Bovine)
Institut De Chimie Pharmaceutique Albert Lespagnol
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 160nM
Assay Description:
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]-prazosin
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Target
D(4) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 168nM
Assay Description:
Antagonist activity at human recombinant at D4 receptor assessed as inhibition of dopamine-induced cAMP accumulation
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 172nM
Assay Description:
Compound was evaluated In vitro for its activity by binding to Dopamine receptor D2 in the rat brain using [3H]-NPA as radioligand.
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Rat)
Universidade Federal Do Rio De Janeiro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Copy SMILES
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Affinity Data
IC50: 179nM
Assay Description:
Displacement of [3H]QNB from Muscarinic acetylcholine receptor of rat brain membrane
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Rat)
Universidade Federal Do Rio De Janeiro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 180nM
Assay Description:
Inhibitory activity against Muscarinic acetylcholine receptor in male olac rat brain, using [3H]-QNB as the radioligand
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Rat)
Universidade Federal Do Rio De Janeiro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 180nM
Assay Description:
The equilibrium dissociation constant of the inhibitor-enzyme complex of human carbonic anhydrase
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Target
D(1A)/D(2) dopamine receptor
(Bovine)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 180nM
Assay Description:
Inhibition of [3H]haloperidol binding to Dopamine receptor in calf caudate nuclei.
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 191nM
Assay Description:
Inhibition of human ERG in MCF7 cells
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 191nM
Assay Description:
K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 192nM
Assay Description:
Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain
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Target
D(1A) dopamine receptor
(Rat)
Vanderbilt University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 192nM
Assay Description:
Binding activity against Dopamine receptor D1 in rat brain, using [3H]-SCH-23,390 as the radioligand
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 204nM
Assay Description:
Inhibition of human dopamine D2L receptor expressed in intact CHO FlpIn cells assessed as inhibition of receptor-mediated mediated ERK1/2 phosphoryla...
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 206nM
Assay Description:
Inhibition of human dopamine D2L receptor expressed in intact CHO FlpIn cells assessed as inhibition of receptor-mediated mediated ERK1/2 phosphoryla...
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 230nM
Assay Description:
In vitro binding affinity at human cloned Dopamine receptor D2 by [3H]-spiroperidol displacement.
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Target
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 247nM
Assay Description:
Displacement of [3H]spiroperidol from Dopamine receptor of rat striatum membrane
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Target
D(2) dopamine receptor
(Bovine)
Universit£T Erlangen-N£Rnberg
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 250nM
Assay Description:
Inhibitory activity against dDopamine receptor D2 in calf caudate tissue, using [3H]spiperone as the radioligand
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 250nM
Assay Description:
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 260nM
Assay Description:
Binding affinity towards human Dopamine receptor D2
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 268nM
Assay Description:
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 290nM
Assay Description:
In vitro inhibitory activity against [3H]raclopride binding to dopamine receptor D2
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 290nM
Assay Description:
Inhibition of [3H]-raclopride binding at Dopamine receptor D2 from rat striata.
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 290nM
Assay Description:
In vitro binding affinity was measured by displacement of [3H]- raclopride from D2 receptor isolated from the striata of male Dawley rats
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Target
D(2) dopamine receptor
(Mouse)
Glaxo Wellcome
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 290nM
Assay Description:
Inhibition of mouse Dopamine receptor D2
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 320nM
Assay Description:
Inhibition of human ERG channel
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 324nM
Assay Description:
Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 324nM
Assay Description:
Inhibitory concentration against potassium channel HERG
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 324nM
Assay Description:
Inhibition of human Potassium channel HERG expressed in mammalian cells
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 330nM
Assay Description:
Binding affinity towards Dopamine receptor D2 of rat corpus striatum using [3H]-spiperone as radioligand
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 330nM
Assay Description:
Binding affinity against dopamine receptor D2
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 330nM
Assay Description:
Inhibitory binding of [3H]-spiperone to Dopamine receptor D2 in membranes from rat corpus striatum
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 400nM
Assay Description:
Ability to inhibit [3H]-spiperone binding to Dopamine receptor D2 in rat corpus striatum
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 410nM
Assay Description:
Compound was tested for the inhibition of [3H]-spiperone binding to dopamine receptor D2
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 440nM
Assay Description:
In vitro inhibitory concentration against radioligand [3H]spiperone binding to rat striatal dopamine receptor D2
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 440nM
Assay Description:
Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperone
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 440nM
Assay Description:
Ability to bind at dopamine receptor D2 of rat corpus striatum by displacing [3H]spiperone
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Target
D(3) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 450nM
Assay Description:
Binding affinity towards human Dopamine receptor D3
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Target
D(2) dopamine receptor
(Bovine)
Universit£T Erlangen-N£Rnberg
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 450nM
Assay Description:
Competition in vitro with the dopamine receptor D2 anatagonist [3H]-spiperone, for binding sites on calf caudate membranes.
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 580nM
Assay Description:
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 587nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 1 receptor was measured using radioligand ([3H]5-HT) binding assay
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 587nM
Assay Description:
Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HT
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 600nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 830nM
Assay Description:
Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.
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Target
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 890nM
Assay Description:
Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranes
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Target
Sigma non-opioid intracellular receptor 1
(Rat)
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Compound was tested in vitro for its ability to displace radioligand (+)-[3H]-3-PPP from rat cortical sigma receptor
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.01E+3nM
Assay Description:
Binding affinity towards serotonin 5-HT1A receptor was determined in rat hippocampus using [3H]8-OH-DPAT as ligand
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.02E+3nM
Assay Description:
In vitro affinity towards 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in hippocampus
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(Rat)
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of specific [3H]clonidine binding (0.4 nM) to rat brain membranes Alpha-2 adrenergic receptor
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.61E+3nM
Assay Description:
Binding affinity towards Dopamine receptor D2 was determined in rat striatal homogenate using [3H]- spiperone as radioligand
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.61E+3nM
Assay Description:
In vitro affinity towards D2 receptor using [3H]-spiroperidol as radioligand in striatum
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
In vitro inhibitory activity against [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of [3H]-8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue.
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Target
5-hydroxytryptamine receptor 1A
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
In vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralin
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Target
5-hydroxytryptamine receptor 1A
(Mouse)
Glaxo Wellcome
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibitory activity against serotonin 5-hydroxytryptamine 1A receptor from mice.
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 2.11E+3nM
Assay Description:
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand
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Target
5-hydroxytryptamine receptor 1B
(Rat)
Institut De Chimie Pharmaceutique Albert Lespagnol
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 2.50E+3nM
Assay Description:
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]-5-HT
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 2.77E+3nM
Assay Description:
Binding affinity for Dopamine receptor D2 using [3H]-spiperone in rat brain
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Target
D(2) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 2.77E+3nM
Assay Description:
Binding activity against dopamine D2 receptor in rat brain, using [3H]-Spiperone as the radioligand
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 2.80E+3nM
Assay Description:
The ability of Compound 102 to bind the dopamine D2 receptor in a membrane preparation was examined. Medium was removed from dopamine D2 receptor cel...
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 3.20E+3nM
Assay Description:
Inhibition of human ERG
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S
(Human)
Chantest
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 3.60E+3nM
Assay Description:
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 3.98E+3nM
Assay Description:
Inhibition of human ERG
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Target
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 4.31E+3nM
Assay Description:
Displacement of 3[H]spiroperidol from Dopamine receptor in rat brain
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Target
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 4.31E+3nM
Assay Description:
Relative affinity for dopamine receptor by displacement of [3H]spiroperidol (2.2 nM) from (in vitro) dopamine binding sites in rat caudate nuclei
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Target
Potassium voltage-gated channel subfamily H member 2
(Human)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 5.75E+3nM
Assay Description:
Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel)
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Target
D(2) dopamine receptor
(Human)
Florida A and M University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 7.10E+3nM
Assay Description:
The ability of Compound 102 to bind dopamine D2 receptors was measured in a cell-based assay. Dopamine D2 receptor cells were seeded in a half a blac...
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Target
D(1A)/D(2) dopamine receptor
(Bovine)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 8.00E+3nM
Assay Description:
Inhibition of [3H]dopamine binding to Dopamine receptor in calf caudate nuclei.
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 8.70E+3nM
Assay Description:
Binding affinity against serotonin-1 receptor in rat brain using [3H]5-HT
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Beta-1 adrenergic receptor
(Rat)
Centro De InvestigacióN Grupo Ferrer
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Binding affinity against beta-1 adrenergic receptor in rat brain using [3H]-DHA
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Target
Beta-2 adrenergic receptor
(Rat)
TBA
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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IC50: >1.00E+4nM
Assay Description:
Binding affinity against beta-2 adrenergic receptor in rat brain using [3H]-DHA
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Sodium-dependent serotonin transporter
(Human)
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of 5-HT uptake at SERT (unknown origin)
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Target
Sodium-dependent serotonin transporter
(Rat)
Institute For Biological Research
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibitory concentration against reuptake of 5-HT from rat synaptosomes
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Target
Cytochrome P450 2J2
(Human)
Tongji University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.41E+4nM
Assay Description:
Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method
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Cytochrome P450 2D6
(Human)
Tongji University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.80E+4nM
Assay Description:
Inhibition of CYP2D6 in human liver microsomes using bufuralol substrate by LC-MS/MS method
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Target
Calmodulin
(Bovine)
University of Bari Aldo Moro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 2.00E+4nM
Assay Description:
Binding affinity to CaM (unknown origin) by equilibrium dialysis method
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Target
Cytochrome P450 2C9
(Human)
Tongji University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 2.12E+4nM
Assay Description:
Inhibition of CYP2C9 in human liver microsomes using tolbutamide substrate by LC-MS/MS method
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Cytochrome P450 2C19
(Human)
Tongji University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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IC50: 4.53E+4nM
Assay Description:
Inhibition of CYP2C19 in human liver microsomes using omeprazole substrate by LC-MS/MS method
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Cytochrome P450 3A4
(Human)
Tongji University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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IC50: 4.63E+4nM
Assay Description:
Inhibition of CYP3A4 in human liver microsomes using testosterone substrate by LC-MS/MS method
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Cytochrome P450 1A2
(Human)
Tongji University
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of CYP1A2 in human liver microsomes using phenacetin substrate by LC-MS/MS method
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Bile salt export pump
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 7.51E+4nM
Assay Description:
Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes. (25% inhibition at 10 e-6 M)
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5-hydroxytryptamine receptor 3A
(Guinea pig)
Czech Republic
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.10E+5nM
Assay Description:
Antagonist activity at 5-HT3 receptor in guinea-pig ileum assessed as inhibition of 5HT-induced contraction
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Target
Bile salt export pump
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.26E+5nM
Assay Description:
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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Target
ATP-binding cassette sub-family C member 3
(Human)
Amgen
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Target
Bile salt export pump
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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ATP-binding cassette sub-family C member 2
(Human)
Amgen
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 4
(Human)
Amgen
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
Bile salt export pump
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: >1.35E+5nM
Assay Description:
Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...
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Calmodulin
(Bovine)
University of Bari Aldo Moro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.40E+5nM
Assay Description:
Competitive binding affinity to human recombinant CaM by Cy5 dye labeled W-7-based fluorescence polarization analysis
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Target
Bile salt export pump
(Rat)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
IC50: 1.97E+5nM
Assay Description:
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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Target
Histamine H1 receptor
(Human)
Intra-Cellular Therapies
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Kd: 3.10nM
Assay Description:
Binding affinity to human histamine H1 receptor
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Muscarinic acetylcholine receptor M1
(Human)
Merck Sharp and Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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EC50: >1.00E+4nM
Assay Description:
Agonist activity at muscarinic M1 receptor (unknown origin) expressed in CHO cells
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Muscarinic acetylcholine receptor M2
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
EC50: >1.00E+4nM
Assay Description:
Agonist activity at muscarinic M2 receptor (unknown origin) expressed in CHO cells
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Target
Albumin
(Rat)
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Kd: 7.88E+4nM
Assay Description:
Binding affinity to Wistar rat serum albumin
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Target
Muscarinic acetylcholine receptor M4
(Human)
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
EC50: >1.00E+4nM
Assay Description:
Agonist activity at muscarinic M4 receptor (unknown origin) expressed in CHO cells
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Target
Calmodulin
(Bovine)
University of Bari Aldo Moro
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Kd: 6.10E+4nM
Assay Description:
Binding affinity to bovine brain CaM by FTPFACE analysis
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Target
Histamine H4 receptor
(Human)
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Kd: 14.5nM
Assay Description:
Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 100 nM
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Target
Histamine H4 receptor
(Human)
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Kd: 11.9nM
Assay Description:
Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells
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Target
Histamine H4 receptor
(Human)
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Kd: 70.2nM
Assay Description:
Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 1 uM
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KEGG
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3D Structure (crystal)
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Target
Muscarinic acetylcholine receptor M3
(Human)
Sumitomo Dainippon Pharma.
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
EC50: >1.00E+4nM
Assay Description:
Agonist activity at muscarinic M3 receptor (unknown origin) expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
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antibodypedia
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Ligand Info
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Target
Histamine H4 receptor
(Human)
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
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Affinity Data
Kd: 20.9nM
Assay Description:
Displacement of [3H]Histamine from human histamine H4 receptor transfected in SK-N-MC cells at 300 nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
DrugBank
PDB
3D Structure (crystal)
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