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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
34
hits in this display
Target
Peptide deformylase, mitochondrial
(Homo sapiens (Human))
Senju Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
Ki: 0.300nM
Assay Description:
Binding affinity of the compound towards Peptide deformylase
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Target
Aminopeptidase N
(Homo sapiens (Human))
Jadavpur University
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
Ki: 170nM
Assay Description:
Competitive inhibition of aminopeptidase-M (unknown origin)
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Target
Neutrophil collagenase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
Ki: 190nM
Assay Description:
Inhibition of human Matrix metalloproteinase-8
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Target
Interstitial collagenase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
Ki: 300nM
Assay Description:
Inhibition of human fibroblast collagenase, matrix metalloproteinase-1
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
Ki: 330nM
Assay Description:
Inhibition of human Matrix metalloproteinase-9
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Target
Stromelysin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
Ki: 1.70E+3nM
Assay Description:
Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3
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Target
Meprin A subunit beta
(Homo sapiens)
Fraunhofer Institute For Cell Therapy And Immunology Izi
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
Ki: 2.00E+3nM
Assay Description:
Inhibition of recombinant human meprin beta expressed in baculovirus infected insect cells using N-benzoyl-L-tyrosyl-p-aminobenzoic acid as substrate
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Target
Meprin A subunit beta
(Homo sapiens)
Fraunhofer Institute For Cell Therapy And Immunology Izi
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
Ki: 2.00E+3nM
Assay Description:
Inhibition of human meprin beta expressed in baculovirus infected BTI-TN-5B1-4 insect cells using N-benzoyl-L-tyrosylp-aminobenzoic acid as substrate
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Target
Aminopeptidase N
(Homo sapiens (Human))
Jadavpur University
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
Ki: 3.00E+5nM
Assay Description:
Inhibition of APM (unknown origin) assessed as inhibition of endomorphin-2 degradation after 30 min
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Target
Aminopeptidase N
(Homo sapiens (Human))
Jadavpur University
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
Ki: 3.90E+5nM
Assay Description:
Inhibition of APM (unknown origin) assessed as inhibition of endomorphin-1 degradation after 30 min
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Target
Peptide deformylase, mitochondrial
(Homo sapiens (Human))
Senju Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 1.5nM
Assay Description:
In vitro inhibitory concentration required against peptide deformylase (PDF)
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Target
Peptide deformylase
(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Genomics Institute Of The Novartis Research Foundation
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: <5nM
Assay Description:
Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus
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Target
Peptide deformylase
(Escherichia coli)
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 6nM
Assay Description:
Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.
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Target
Peptide deformylase, mitochondrial
(Homo sapiens (Human))
Senju Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 10nM
Assay Description:
Antibacterial activity of the compound against E. coli Peptide deformylase. Ni
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Target
Peptide deformylase
(Escherichia coli)
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 10nM
Assay Description:
Inhibition of PDF1B
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Target
Peptide deformylase
(Staphylococcus aureus)
Korea Research Institute Of Bioscience And Biotechnology
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 20nM
Assay Description:
Inhibition of Staphylococcus aureus peptide deformylase using N-formylmethionine-alanine-serine as substrate by spectrophotometry
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Target
Peptide deformylase 1A, chloroplastic/mitochondrial
(Arabidopsis thaliana)
Centre National De La Recherche Scientifique
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 27nM
Assay Description:
Inhibition of Arabidopsis thaliana mitochondrial PDF1A
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Target
Peptide deformylase, mitochondrial
(Homo sapiens (Human))
Senju Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 30nM
Assay Description:
Inhibition of human PDF using N-formylated peptide as substrate in presence of NAD+ by formate dehydrogenase-coupled spectrophotometric assay
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Target
Peptide deformylase, mitochondrial
(Homo sapiens (Human))
Senju Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 32nM
Assay Description:
Inhibition of human PDF expressed in Escherichia coli BL21 pLysS using formyl-Met-Ala-His-Ala peptide as substrate measured after 1 hr by fluorescami...
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Target
Peptide deformylase
(Escherichia coli)
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 140nM
Assay Description:
Inhibition of Escherichia coli peptide deformylase using fMAHA as substrate after 1 hr by FLUO assay
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Target
Aminopeptidase N
(Homo sapiens (Human))
Jadavpur University
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 400nM
Assay Description:
Competitive inhibition of aminopeptidase-M (unknown origin)
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Target
Peptide deformylase, mitochondrial
(Homo sapiens (Human))
Senju Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 600nM
Assay Description:
Inhibition of human mitochondrial PDF
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Target
Aminopeptidase N
(Homo sapiens (Human))
Jadavpur University
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 830nM
Assay Description:
Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method.
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Target
Interstitial collagenase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human Matrix metalloproteinase-1
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Target
Peptide deformylase, mitochondrial
(Homo sapiens (Human))
Senju Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 2.70E+3nM
Assay Description:
Inhibition of human peptide deformylase after 1 hr by fluorescence polarization based competition assay
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
British Biotech Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of Matrix metalloproteinase-2
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Target
Endothelin-converting enzyme 1
(Homo sapiens (Human))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 4.00E+3nM
Assay Description:
Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1
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Target
Stromelysin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 6.00E+3nM
Assay Description:
Inhibition of Matrix metalloproteinase-3
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Target
Neprilysin
(Homo sapiens (Human))
British Biotech Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 6.70E+3nM
Assay Description:
The compound was evaluated in vitro for the inhibition of Neutral endopeptidase
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Neprilysin
(Oryctolagus cuniculus (rabbit))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: 8.20E+3nM
Assay Description:
Inhibitory activity against big ET-1 of Neutral endopeptidase
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Target
Histone deacetylase 6
(Homo sapiens (Human))
Sun Yat-Sen University
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of HDAC6 (unknown origin) using Boc-Lys(Ac)-pNA as substrate preincubated for 20 mins followed by substrate addition and further incubated...
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Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Sun Yat-Sen University
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of HDAC1 (unknown origin) using Boc-Lys(Ac)-pNA as substrate preincubated for 20 mins followed by substrate addition and further incubated...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Angiotensin-converting enzyme
(Homo sapiens (Human))
British Biotech Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Compound was tested for its inhibitory activity against Angiotensin I converting enzyme
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
KEGG
MMDB
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In Depth
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Article
PubMed
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Target
Dipeptidyl peptidase 4
(Homo sapiens (Human))
University Of Tokyo
Curated by
ChEMBL
Ligand
BDBM50089194
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
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Affinity Data
IC50: >2.59E+5nM
Assay Description:
Inhibitory activity against dipeptidyl peptidase IV (DPP- IV)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI