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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
24
hits in this display
Target
Albumin
(Homo sapiens (Human))
Molecular Discovery
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
Ki: 3.98E+4nM
Assay Description:
Binding affinity towards human serum albumin
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Target
Solute carrier family 22 member 6
(Rattus norvegicus)
University Of California
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
Ki: 5.55E+4nM
Assay Description:
Inhibition of rat Oat1 expressed in Xenopus oocytes
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Target
Solute carrier family 22 member 6
(Rattus norvegicus)
University Of California
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
Ki: 5.55E+4nM
Assay Description:
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Washington State University
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
Ki: 7.00E+4nM
Assay Description:
Binding affinity measured on human cytochrome P450 2C9 (CYP2C9) enzyme
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Washington State University
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: 380nM
Assay Description:
Inhibition of CYP2C9 in human liver microsomes incubated for 15 to 40 mins in presence of NADPH
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Washington State University
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: 404nM
Assay Description:
Inhibition of CYP2C9 (unknown origin)
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Target
Genome polyprotein
(West Nile virus)
University of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
The HTS assay to identify Inhibitors of West Nile Virus (WNV) NS2bNS3 Proteinase was proposed by Dr Alex Strongin of the Burnham Institute XO1-MH0776...
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Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >1.35E+5nM
Assay Description:
Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...
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Target
Lanosterol 14-alpha demethylase
(Homo sapiens (Human))
Act
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >2.00E+5nM
Assay Description:
Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay
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Target
UDP-glucuronosyltransferase 1-6
(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: 2.81E+5nM
Assay Description:
Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.
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Target
UDP-glucuronosyltransferase 1A4
(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >3.00E+5nM
Assay Description:
Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.
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Target
UDP-glucuronosyltransferase 1A1
(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >3.00E+5nM
Assay Description:
Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.
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Target
UDP-glucuronosyltransferase 2B10
(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >3.00E+5nM
Assay Description:
Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.
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Target
UDP-glucuronosyltransferase 2B7
(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >3.00E+5nM
Assay Description:
Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.
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Target
Bile salt export pump
(Rattus norvegicus)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
Copy SMILES
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Target
Albumin
(Homo sapiens (Human))
Molecular Discovery
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
Kd: 6.03E+3nM
Assay Description:
Binding affinity to human serum albumin by PAMPA method
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Target
Albumin
(Rattus norvegicus)
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
Kd: 7.97E+3nM
Assay Description:
Binding affinity to Wistar rat serum albumin
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Target
Potassium channel subfamily K member 2
(Homo sapiens (Human))
Korea Institute of Science and Technology
Ligand
BDBM50027886
(1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3...)
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Affinity Data
EC50: 7.84E+5nM
pH: 7.3 T: 2°C
Assay Description:
The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...
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