Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 100 hits in this display
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 40nMAssay Description:Displacement of tetra-acetylated histone H4 peptide from recombinant human N-terminal His-tagged BRD4 BD2 incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 203nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 251nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 510nMAssay Description:Inhibition of human His-tagged BRD3 bromodomain 2 using biotin-H4K5acK8acK12acK16ac as substrate incubated for 30 mins by alphascreen assayMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 510nMAssay Description:Inhibition of C-terminal biotin-labelled BCoR/wild-type BCL6 BTB domain (unknown origin) protein-protein interaction by ELISAMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 708nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 1.14E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 1.15E+3nMAssay Description:Binding affinity recombinant human BRD4 BD1 (42 to 168 residues) expressed in Escherichia coli BL21(DE3) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 1.80E+3nMAssay Description:Displacement of tetra-acetylated histone H4 peptide from recombinant human N-terminal His-tagged BRD4 BD1 incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 1.99E+3nMAssay Description:Inhibition of C-terminal biotin-labelled BCoR/wild-type BCL6 BTB domain (unknown origin) protein-protein interaction by ELISAMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 2.45E+3nMAssay Description:Inhibition of GST-tagged BRD4 bromodomain (unknown origin) using biotinylated histone H4KAc peptide (1 to 21 residues) as substrate by HTRF assayMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 3.96E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 4.84E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: 5.78E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
IC50: >1.00E+4nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
Kd: 140nMAssay Description:Binding affinity to human BRD4 bromodomain 2 expressed in Escherichia coli BL21 (DE3) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
Kd: 1.10E+3nMAssay Description:Binding affinity to human BRD4 bromodomain 1 expressed in Escherichia coli BL21 (DE3) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
Kd: 250nMAssay Description:Binding affinity to human BRD2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
Kd: 5.80E+3nMAssay Description:Binding affinity to human BRD2 bromodomain 1 expressed in Escherichia coli BL21 (DE3) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
Kd: 5.78E+3nMAssay Description:Inhibition of recombinant human His6-tagged BRD2 bromodomain 1 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cellsMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
Kd: 4.07E+3nMAssay Description:Inhibition of recombinant human His6-tagged BRD3 bromodomain 1 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cellsMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
Kd: 251nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 2 (E352 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
Kd: 195nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 2 (E352 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208)
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