Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 20 hits in this display   

TargetMacrophage metalloelastase(Homo sapiens (Human))
Commissariat Á

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  3.60nM ΔG°:  -48.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

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TargetMacrophage metalloelastase(Homo sapiens (Human))
Commissariat Á

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  3.65nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

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TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Commissariat Á

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  113nM ΔG°:  -39.7kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

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TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  203nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

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TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  203nM ΔG°:  -38.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Target72 kDa type IV collagenase(Homo sapiens (Human))
Commissariat Á

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  377nM ΔG°:  -36.7kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

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Target72 kDa type IV collagenase(Homo sapiens (Human))
Commissariat Á

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  377nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  603nM ΔG°:  -35.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

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TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  603nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetMatrix metalloproteinase-14 [1-20,P8S](Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoMMDBReactome pathway
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TargetStromelysin-2(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
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TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
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TargetStromelysin-1(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  2.63E+3nM ΔG°:  -31.9kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetStromelysin-1(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  3.00E+3nM ΔG°:  -31.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Commissariat Á

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  3.01E+3nM ΔG°:  -31.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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antibodypediaGoogleScholar

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TargetStromelysin-2(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  3.11E+3nM ΔG°:  -31.4kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Commissariat Á

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi:  4.20E+3nM ΔG°:  -31.9kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetInterstitial collagenase(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
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TargetMatrilysin(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92445(Inhibitor, 10 | US8691753, 105)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI