BDBM92445 Inhibitor, 10::US8691753, 105

SMILES NC(=O)[C@H](CCC(O)=O)NC(=O)CCc1ccc(cc1)-c1cc(cs1)-c1ccccc1

InChI Key InChIKey=KDDWLGBIYXTPJG-UHFFFAOYSA-N

Data  20 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 92445   

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  3.60nM ΔG°:  -11.5kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  3.65nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  113nM ΔG°:  -9.47kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeutrophil collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  203nM ΔG°:  -9.12kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeutrophil collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  203nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target72 kDa type IV collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  377nM ΔG°:  -8.76kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  377nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCollagenase 3(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  603nM ΔG°:  -8.48kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  603nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMatrix metalloproteinase-14 [1-20,P8S](Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStromelysin-1(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMatrix metalloproteinase-9(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStromelysin-2(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMatrix metalloproteinase-9(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  2.63E+3nM ΔG°:  -7.61kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStromelysin-1(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  3.00E+3nM ΔG°:  -7.53kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-14(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  3.01E+3nM ΔG°:  -7.53kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStromelysin-2(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  3.11E+3nM ΔG°:  -7.51kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi:  4.20E+3nM ΔG°:  -7.62kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi: >1.00E+4nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMatrilysin(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92445(US8691753, 105 | Inhibitor, 10)
Affinity DataKi: >1.00E+4nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent