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Found 94 Enz. Inhib. hit(s) with all data for entry = 50018160
TargetSerine-protein kinase ATM(Homo sapiens (Human))TBA
LigandPNGBDBM50550657(CHEMBL4792737)
Affinity DataKi:  0.5nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))TBA
LigandPNGBDBM50571459(CHEMBL4872830)
Affinity DataKi:  1nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO),More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))TBA
LigandPNGBDBM50059640(CHEMBL2140173)
Affinity DataKi:  2nMAssay Description:Ability to inhibit U-46,619-induced contraction of isolated strips of rabbit thoracic aorta, which is the measure of thromboxane receptor antagonismMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50039197(1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50550657(CHEMBL4792737)
Affinity DataKi:  15nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO), (at a concentration of 0.2 nM ),More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50059640(CHEMBL2140173)
Affinity DataKi:  17nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO),More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50571459(CHEMBL4872830)
Affinity DataKi:  50nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM50234890(CHEMBL4077018)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity against beta-2 adrenergic receptor in isolated guinea pig tracheaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM50405622(CHEMBL5271950)
Affinity DataIC50:  4.70nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405611(CHEMBL5273419)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50405622(CHEMBL5271950)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))TBA
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
TargetHuntingtin(Homo sapiens (Human))TBA
LigandPNGBDBM50595435(CHEMBL5179682)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein-glutamine gamma-glutamyltransferase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50420459(CHEMBL2086528)
Affinity DataIC50:  10nMAssay Description:Ability to inhibit U-46,619-induced contraction of isolated strips of rabbit thoracic aorta, which is the measure of thromboxane receptor antagonismMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50253320(2-(4-(4-Fluorophenyl)-5-(2-(3-methylbutan-2-ylamin...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405609(CHEMBL5288429)
Affinity DataIC50:  17nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405605(CHEMBL5273125)
Affinity DataIC50:  17nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50234888(CHEMBL4074524)
Affinity DataIC50:  17nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405607(CHEMBL5267784)
Affinity DataIC50:  17nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405608(CHEMBL5274332)
Affinity DataIC50:  17nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
LigandPNGBDBM50405610(CHEMBL5283014)
Affinity DataIC50:  17nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM50103104(CHEMBL3394106)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))TBA
LigandPNGBDBM50072083(CHEMBL3407929)
Affinity DataIC50:  20nMAssay Description:Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.0More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))TBA
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM50234888(CHEMBL4074524)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50405626(CHEMBL5269500)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from Plasmodium bergheiMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataIC50:  24nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50405624(CHEMBL5284967)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM50405623(CHEMBL5287474)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from Neisseria gonorrhoeaeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50405625(CHEMBL5274433)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from Plasmodium bergheiMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50103104(CHEMBL3394106)
Affinity DataIC50:  30nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50405623(CHEMBL5287474)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from Plasmodium bergheiMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50234890(CHEMBL4077018)
Affinity DataIC50:  36nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))TBA
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50:  37nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHuntingtin(Homo sapiens (Human))TBA
LigandPNGBDBM50595433(CHEMBL5195936)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))TBA
LigandPNGBDBM50405618(CHEMBL5286810)
Affinity DataIC50:  40nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50405620(CHEMBL5271538)
Affinity DataIC50:  47nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM50405624(CHEMBL5284967)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))TBA
LigandPNGBDBM50405617(CHEMBL5269131)
Affinity DataIC50:  54nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein-glutamine gamma-glutamyltransferase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50405621(CHEMBL5283861)
Affinity DataIC50:  62nMAssay Description:Ability to inhibit U-46,619-induced contraction of isolated strips of rabbit thoracic aorta, which is the measure of thromboxane receptor antagonismMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM50405625(CHEMBL5274433)
Affinity DataIC50:  74nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHuntingtin(Homo sapiens (Human))TBA
LigandPNGBDBM50595434(CHEMBL5175104)
Affinity DataIC50:  80nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM50405627(CHEMBL5281537)
Affinity DataIC50:  94nMAssay Description:Antagonist activity against beta-2 adrenergic receptor in isolated guinea pig tracheaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50405619(CHEMBL5275178)
Affinity DataIC50:  98nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))TBA
LigandPNGBDBM50160879(CHEMBL3793392 | US9505736, (1S,2S,3S)-1-Fluoro-2-(...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50156820(CHEMBL426183 | N-{4-[5-(4-fluorophenyl)-3-(2-metho...)
Affinity DataIC50:  108nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO),More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein-glutamine gamma-glutamyltransferase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50392906(CHEMBL2152204)
Affinity DataIC50:  110nMAssay Description:Ability to inhibit U-46,619-induced contraction of isolated strips of rat aorta, which is the measure of thromboxane receptor antagonismMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM50253320(2-(4-(4-Fluorophenyl)-5-(2-(3-methylbutan-2-ylamin...)
Affinity DataIC50:  181nMAssay Description:Antagonist activity against beta-2 adrenergic receptor in isolated guinea pig tracheaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM50599929(CHEMBL5194871)
Affinity DataIC50:  184nMAssay Description:Antagonist activity against beta-2 adrenergic receptor in isolated guinea pig tracheaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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