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Found 5 Enz. Inhib. hit(s) with Target = '5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase' and Ligand = 'BDBM36435'
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College of Medicine

LigandPNGBDBM36435((3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthi...)
Affinity DataKi:  0.0700nM ΔG°:  -58.0kJ/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Klebsiella pneumoniae)
Albert Einstein College of Medicine

LigandPNGBDBM36435((3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthi...)
Affinity DataKd:  2.20nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College of Medicine

LigandPNGBDBM36435((3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthi...)
Affinity DataKd:  0.000950nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Neisseria meningitidis)
Albert Einstein College of Medicine

LigandPNGBDBM36435((3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthi...)
Affinity DataKd:  0.0460nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Staphylococcus aureus)
Albert Einstein College of Medicine

LigandPNGBDBM36435((3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthi...)
Affinity DataKd:  1.30nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed