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Found 5 Enz. Inhib. hit(s) with Target = 'Interleukin-1 receptor-associated kinase 4' and Ligand = 'BDBM50242697'
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50242697(CHEMBL4070214 | US9932350, 2-7)
Affinity DataIC50:  6nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50242697(CHEMBL4070214 | US9932350, 2-7)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human full length GST tagged IRAK4 expressed in baculovirus infected Sf9 cells using RP7030 peptide as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50242697(CHEMBL4070214 | US9932350, 2-7)
Affinity DataIC50:  46nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of 5 mM ATP by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50242697(CHEMBL4070214 | US9932350, 2-7)
Affinity DataIC50:  250nMAssay Description:Inhibition of IRAK4 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50242697(CHEMBL4070214 | US9932350, 2-7)
Affinity DataEC50:  2.30E+3nMAssay Description:Inhibition of specific binding of [3H]DTG to sigma binding site in Guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed