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Found 3 Enz. Inhib. hit(s) with Target = 'Melatonin receptor type 1B' and Ligand = 'BDBM463444'
TargetMelatonin receptor type 1B(Homo sapiens (Human))
AchÉ

US Patent
LigandPNGBDBM463444(US10781182, Compound IA2-121 | US11091445, Compoun...)
Affinity DataKi:  0.930nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
AchÉ

US Patent
LigandPNGBDBM463444(US10781182, Compound IA2-121 | US11091445, Compoun...)
Affinity DataKi:  0.930nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
AchÉ

US Patent
LigandPNGBDBM463444(US10781182, Compound IA2-121 | US11091445, Compoun...)
Affinity DataEC50:  0.270nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed