Found 3 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase kinase 1' and Ligand = 'BDBM50598497' TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of HPK1 (unknown origin) in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 2.20nMAssay Description:Binding affinity to HPK1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataEC50: 149nMAssay Description:Inhibition of HPK1(unknown origin) assessed as inhibition of SLP76 phosphorylation by cell based assayMore data for this Ligand-Target Pair
