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Found 4 Enz. Inhib. hit(s) with Target = 'Proteinase-activated receptor 1' and Ligand = 'BDBM50386408'
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386408(CHEMBL2047297)
Affinity DataIC50:  340nMAssay Description:Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386408(CHEMBL2047297)
Affinity DataIC50:  970nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386408(CHEMBL2047297)
Affinity DataIC50:  1.00E+3nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386408(CHEMBL2047297)
Affinity DataIC50:  1.00E+3nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed