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Found 4 Enz. Inhib. hit(s) with Target = 'Tryptophan 2,3-dioxygenase' and Ligand = 'BDBM50442995'
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442995(CHEMBL3086870)
Affinity DataKi:  876nMAssay Description:Mixed type uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442995(CHEMBL3086870)
Affinity DataIC50:  241nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442995(CHEMBL3086870)
Affinity DataIC50:  503nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442995(CHEMBL3086870)
Affinity DataIC50:  9.81E+3nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed