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TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataEC50:  27nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A-431 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataEC50:  22nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A-431 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  1.19E+3nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A-431 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataEC50:  22nMAssay Description:Inhibition of EGFR T790M mutant phosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataEC50:  40nMAssay Description:Inhibition of EGFR T790M mutant phosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  15nMAssay Description:Inhibition of EGFR T790M mutant phosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50161957(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(p...)
Affinity DataEC50:  3nMAssay Description:Inhibition of EGF-stimulated EGFR phosphorylation in human A-431 cells incubated for 3 hrs followed by replacement with fresh medium without compound...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50161957(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(p...)
Affinity DataEC50: <100nMAssay Description:Inhibition of EGFR phosphorylation in human NCI-H1975 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataEC50:  70nMAssay Description:Inhibition of EGFR phosphorylation in human A-431 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Affinity DataEC50:  390nMAssay Description:Inhibition of EGFR phosphorylation in human A-431 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataEC50:  4.70E+3nMAssay Description:Inhibition of EGFR phosphorylation in human A-431 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50602487(CHEMBL5183286)
Affinity DataEC50:  5.80nMAssay Description:Inhibition of wild type human EGFR expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of EGFR phosphorylation in human A431 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50559921(CHEMBL4755977)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of EGFR phosphorylation in human A431 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataEC50:  49nMAssay Description:Inhibition of EGFR phosphorylation in human A431 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of EGFR phosphorylation in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataEC50:  30nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  57nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50579856(CHEMBL5083976)
Affinity DataEC50:  2.55E+3nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50579857(CHEMBL5077776)
Affinity DataEC50:  40nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50579858(CHEMBL5088102)
Affinity DataEC50:  2.18E+3nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50579859(CHEMBL5089073)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50579860(CHEMBL5076067)
Affinity DataEC50:  3.10nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50579861(CHEMBL5085118)
Affinity DataEC50:  12nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50579862(CHEMBL5079430)
Affinity DataEC50:  8.80nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataEC50:  7.5nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimulation and measur...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  286nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimulation and measur...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50579857(CHEMBL5077776)
Affinity DataEC50:  308nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimulation and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50579860(CHEMBL5076067)
Affinity DataEC50:  277nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimulation and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50579861(CHEMBL5085118)
Affinity DataEC50:  165nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimulation and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50579862(CHEMBL5079430)
Affinity DataEC50:  562nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimulation and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  480nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human LoVo cells preincubated for 2 hrs followed by EGF stimulation and measured after...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  2.38E+3nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human A-431 cells preincubated for 2 hrs followed by EGF stimulation and measured afte...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  2.37E+3nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human A-431 cells preincubated for 2 hrs followed by EGF stimulation and measured afte...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  1.87E+3nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H2073 cells preincubated for 2 hrs followed by EGF stimulation and measured ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50591176(CHEMBL5183997)
Affinity DataEC50:  20nMAssay Description:Inhibition of EGFR T790M mutant in human NCI-H1975 cells incubated for 24 hrs under serum free medium by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50591183(CHEMBL5170694)
Affinity DataEC50:  143nMAssay Description:Inhibition of EGFR in human NCI-H1975 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50591184(CHEMBL5172973)
Affinity DataEC50:  579nMAssay Description:Inhibition of EGFR in human NCI-H1975 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  190nMAssay Description:Inhibition of EGFR in human DFCI032 cells assessed as reduction in cell viability after 72 hrs in presence of ceritinib by MTS assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  4.73E+3nMAssay Description:Inhibition of EGFR in human DFCI032 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50520595(CHEMBL4565984)
Affinity DataEC50:  6nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataEC50:  31nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  3.21E+3nMAssay Description:Inhibition of EGFR in human DFCI076 cells assessed as reduction in cell viability after 72 hrs by MTS assay in presence of ceritinibMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataEC50:  7.93E+3nMAssay Description:Inhibition of EGFR in human DFCI076 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50520596(CHEMBL4558227)
Affinity DataEC50:  68nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50520589(CHEMBL4473365)
Affinity DataEC50:  4nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50520584(CHEMBL4448107)
Affinity DataEC50:  5nMAssay Description:Inhibition of EGFR exon19 deletion mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50520595(CHEMBL4565984)
Affinity DataEC50:  6nMAssay Description:Inhibition of EGFR exon19 deletion mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50520595(CHEMBL4565984)
Affinity DataEC50:  5nMAssay Description:Inhibition of EGFR T790M exon19 deletion double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50520584(CHEMBL4448107)
Affinity DataEC50:  25nMAssay Description:Inhibition of wild type EGFR (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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