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TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50096484((4S,6R)-6-Allyl-4-(naphthalene-2-sulfonyl)-5-oxo-h...)
Affinity DataIC50:  0.0360nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50066997((3aS,6R)-6-Allyl-4-methanesulfonyl-5-oxo-hexahydro...)
Affinity DataIC50:  0.0470nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50066999((S)-3,3-Diethyl-2-[4-(4-methyl-piperazine-1-carbon...)
Affinity DataIC50:  0.450nMAssay Description:In vitro inhibitory activity in human whole blood (HWB) elastase at a concentration of 10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50354849(CCI-18781 | Cutivate | FLUTICASONE PROPIONATE | Fl...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of [3H]-dexamethasone binding to human Glucocorticoid ReceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50096486(CHEMBL2367646 | benzyl (3aS,6aR)-4-acetyl-6-allyl-...)
Affinity DataIC50:  0.690nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50096488((1S,3R)-1-(Naphthalene-2-sulfonyl)-4-(3-piperidin-...)
Affinity DataIC50:  1nMAssay Description:Binding affinity for dopamine D4-like receptor labelled with [3H]YM-09151-2 in retinaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50096488((1S,3R)-1-(Naphthalene-2-sulfonyl)-4-(3-piperidin-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50096487((3R,6aS)-3-Allyl-2-oxo-hexahydro-pyrrolo[3,2-b]pyr...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50096483((3R,6aS)-1-Methanesulfonyl-4-(3-piperidin-1-yl-pro...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory activity in human whole blood (HWB) elastase at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041945(1N-ethyl-2-benzylcarboxamido-2-[4-{2-[2-benzylcarb...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083757(CHEMBL302366 | Isomer of 4b,12-Difluoro-5-hydroxy-...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of [3H]-dexamethasone binding to human Glucocorticoid ReceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083757(CHEMBL302366 | Isomer of 4b,12-Difluoro-5-hydroxy-...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of [3H]-dexamethasone binding to human Glucocorticoid ReceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50:  4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041946(1N-(2,2,2-trifluoroethyl)-2-benzylcarboxamido-2-[4...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041944(1N-benzyl-2-[4-{3-[2-benzylcarbamoyl(benzylcarboxa...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041949(4N-{2-[5-ethylcarbamoyl(5-methyl-3-phenyl-4-isoxaz...)
Affinity DataIC50:  5.40nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50041948(4N-{2-[5-ethylcarbamoyl(2-phenylphenylcarboxamido)...)
Affinity DataIC50:  9.90nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50061024((2-Methyl-1-{(S)-oxo-[(S)-2-((S)-3,3,3-trifluoro-1...)
Affinity DataIC50: >10nMAssay Description:In vitro inhibitory activity in human whole blood (HWB) elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118028(3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-yl...)
Affinity DataIC50:  10nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118030(4-(5-Cyclopropylaminomethyl-pyrazine-2-carbonyl)-3...)
Affinity DataIC50:  11nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50098095((3S,3aR,6aS)-3-Isopropyl-1-methanesulfonyl-5-((E)-...)
Affinity DataIC50:  22nMAssay Description:Inhibitory concentration against ElastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataIC50:  22nMAssay Description:The compound was evaluated for its inhibitory activity against Chymotrypsinogen using selectivity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataIC50:  22nMAssay Description:The compound was evaluated for its inhibitory activity against dog neutrophil elastase using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataIC50:  22nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50098094((3R,6aR)-3-Isopropyl-1-methanesulfonyl-5-((E)-4-pi...)
Affinity DataIC50:  26nMAssay Description:Inhibitory concentration against ElastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50096490((3aS,6R)-6-Allyl-4-hexyl-5-oxo-hexahydro-pyrrolo[3...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50096485((3aS,6R)-6-Allyl-4-ethylcarbamoyl-5-oxo-hexahydro-...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataIC50:  37nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Gsk Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50300479(3-hydroxy-5-(4-(pyridin-4-yl)phenyl)pentanoic acid...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Gsk Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50300470(3-hydroxy-5-(4'-(methylthio)biphenyl-4-yl)pentanoi...)
Affinity DataIC50:  58nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Gsk Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50300471(5-(4'-acetylbiphenyl-4-yl)-3-hydroxypentanoic acid...)
Affinity DataIC50:  62nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50:  79nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
Harvard School of Public Health

LigandPNGBDBM50379156(CHEMBL2012958 | Genz-669178)
Affinity DataIC50:  80nMAssay Description:Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Gsk Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50300472(5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid ...)
Affinity DataIC50:  86nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50096489((3aS,6R)-6-Allyl-4-formyl-5-oxo-hexahydro-pyrrolo[...)
Affinity DataIC50:  94nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50098097((3R,3aS,6aR)-1-Methanesulfonyl-5-(3-piperidin-1-yl...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration against ElastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50096483((3R,6aS)-1-Methanesulfonyl-4-(3-piperidin-1-yl-pro...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibitory activity in human whole blood (HWB) elastase at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118030(4-(5-Cyclopropylaminomethyl-pyrazine-2-carbonyl)-3...)
Affinity DataIC50:  150nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50:  158nMAssay Description:Inhibition of IR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50:  158nMAssay Description:Inhibition of Bmx (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataIC50:  170nMAssay Description:The compound was evaluated for its inhibitory activity against dog neutrophil elastase using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Gsk Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50300480(5-(4-(benzofuran-2-yl)phenyl)-3-hydroxypentanoic a...)
Affinity DataIC50:  181nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataIC50:  190nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083758(CHEMBL63241 | Sodium Salt of 2-[2-(4b,12-Difluoro-...)
Affinity DataIC50:  194nMAssay Description:Inhibition of [3H]-dexamethasone binding to human Glucocorticoid ReceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50:  200nMAssay Description:Inhibition of CAMKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50098096((3R,3aS,6aR)-3-Isopropyl-1-methanesulfonyl-5-(3-pi...)
Affinity DataIC50:  242nMAssay Description:Inhibitory concentration against ElastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118028(3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-yl...)
Affinity DataIC50:  250nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50:  251nMAssay Description:Inhibition of Tec (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118030(4-(5-Cyclopropylaminomethyl-pyrazine-2-carbonyl)-3...)
Affinity DataIC50:  260nMAssay Description:The compound was evaluated for its inhibitory activity against dog neutrophil elastase using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50098098((3R,3aS,6aR)-3-Isopropyl-1-methanesulfonyl-5-((E)-...)
Affinity DataIC50:  274nMAssay Description:Inhibitory concentration against ElastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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