Compile Data Set for Download or QSAR
maximum 50k data
Found 200 of ic50 for UniProtKB: P00760
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50:  0.00800nMAssay Description:Concentration of the compound required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  0.0450nMAssay Description:Concentration of the compound required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50290996(3-tert-Butoxycarbonylamino-4-[2-(4-guanidino-1-phe...)
Affinity DataIC50:  0.760nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50291175(((R)-1-Benzyl-2-{(S)-2-[(R)-4-guanidino-1-(thiazol...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50291167(1-((S)-Oxo-3-(R)-2-amino-1-phenyl-propyl)-pyrrolid...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM14140((2S)-1-[(2S)-2-amino-3-phenylpropanoyl]-N-[1-(1,3-...)
Affinity DataIC50:  5.80nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029499(CHEMBL141834 | tert-butyloxy carbonyl-D-Phe-thiazo...)
Affinity DataIC50:  8.80nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50291173(1-((S)-2-Amino-3-(R)-phenyl-propionyl)-azetidine-2...)
Affinity DataIC50:  9nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029498(1N-[2-{2-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50:  9.60nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029515(CHEMBL141584 | tert-butyloxy carbonyl-D-Phe-azetid...)
Affinity DataIC50:  9.70nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029506(CHEMBL318998 | tert-butyloxy carbonyl-D-ethylpheny...)
Affinity DataIC50:  9.80nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM29388(Exanta | Melagatran | US11584714, Compound 999)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity against trypsinMore data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029514((S)-1-((R)-2-Acetylamino-2-phenyl-propionyl)-azeti...)
Affinity DataIC50:  11nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029510(1N-[2-{2-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50:  11nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  13nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029511(CHEMBL104472 | tert-butyloxy carbonyl-D-Phe-pro-Ar...)
Affinity DataIC50:  14nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129034(((R)-2-{(S)-2-[(5-Carbamimidoyl-1H-pyrrol-2-ylmeth...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50:  17nMAssay Description:The compound was evaluated to inhibit trypsinand is expressed in IC50 (The concentration required to inhibit 50% of the enzyme).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50060000((S)-1-((R)-2-Methylamino-2-phenyl-acetyl)-pyrrolid...)
Affinity DataIC50:  20nMAssay Description:In vitro ability to inhibit the activity of TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50280654((S)-5-Guanidino-2-{[(S)-1-((S)-2-methylamino-2-phe...)
Affinity DataIC50:  20nMAssay Description:In vitro concentration of compound required to inhibit 50% of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM65488(MdnA6)
Affinity DataIC50:  21.5nMT: 2°CAssay Description:The inhibition assays were performed in 96-well microtiter plates as follows: 30 uL of the enzyme solution (trypsin [100 ug/mL] or elastase [1.5 U/mL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029507(CHEMBL2370860 | {(R)-2-[2-((S)-1-Formyl-4-guanidin...)
Affinity DataIC50:  22nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029500((S)-1-((S)-1,2,3,4-Tetrahydro-isoquinoline-3-carbo...)
Affinity DataIC50:  23nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM65473(MdnA3)
Affinity DataIC50:  28.4nMT: 2°CAssay Description:The inhibition assays were performed in 96-well microtiter plates as follows: 30 uL of the enzyme solution (trypsin [100 ug/mL] or elastase [1.5 U/mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM14063((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)
Affinity DataKi:  3.10nM IC50:  30nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM14073((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)
Affinity DataIC50:  30nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM14075((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)
Affinity DataIC50:  32nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50101132(1,3-Dibenzyl-[1,3]diazetidine-2,4-dione | CHEMBL47...)
Affinity DataIC50:  39nMAssay Description:Compound was evaluated for its inhibitory activity against bovine pancreatic trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029501(5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]...)
Affinity DataIC50:  53nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120368((2S,3R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carb...)
Affinity DataIC50:  72nMAssay Description:Inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50290019((3S,6S,9aS)-6-(3-Methyl-1,2,3,4-tetrahydro-quinoli...)
Affinity DataIC50:  100nMAssay Description:In vitro ability to inhibit the activity of TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50290993(2-(N'-Acetyl-N-benzyl-hydrazinocarbonyl)-cyclohexa...)
Affinity DataIC50:  108nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144554((R)-1-[4-(Biphenyl-4-carbonyl)-piperazine-1-carbon...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144558((R)-1-[4-(4-Benzyloxy-benzoyl)-piperazine-1-carbon...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144553((R)-4-Oxo-1-[4-(4-phenoxy-benzoyl)-piperazine-1-ca...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144580((R)-1-(4-{4-[3-(4-Chloro-phenyl)-[1,2,4]oxadiazol-...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50289433((S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  156nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029512(CHEMBL139910 | tert-butyloxy carbonyl-D-Phe-DL-Pro...)
Affinity DataIC50:  170nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31459(CHEMBL224485 | substituted biphenyl derivative, 21)
Affinity DataIC50:  170nMT: 2°CAssay Description:Trypsin assay reactions were performed in a mixture containing trypsin, and test compounds were added at varied concentrations. The reactions were in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029502(1N-[2-[5-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50:  180nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50291166((R)-2-((R)-2-Amino-3-phenyl-propionylamino)-N-[(S)...)
Affinity DataIC50:  180nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50101131(1,3-Di-p-tolyl-[1,3]diazetidine-2,4-dione | CHEMBL...)
Affinity DataIC50:  200nMAssay Description:Compound was evaluated for its inhibitory activity against bovine pancreatic trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50291172((S)-1-(3-Phenyl-propionyl)-pyrrolidine-2-carboxyli...)
Affinity DataIC50:  230nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50291170((S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  230nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50291171((S)-1-(4-Phenyl-butyryl)-pyrrolidine-2-carboxylic ...)
Affinity DataIC50:  230nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31486(substituted biphenyl derivative, 36z)
Affinity DataIC50:  240nMT: 2°CAssay Description:Trypsin assay reactions were performed in a mixture containing trypsin, and test compounds were added at varied concentrations. The reactions were in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144577((R)-1-[4-(6-Naphthalen-1-yl-hexanoyl)-piperazine-1...)
Affinity DataIC50:  240nMAssay Description:Inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50291000(CHEMBL110631 | {N'-tert-Butoxycarbonyl-N-[2-(1-for...)
Affinity DataIC50:  250nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50290999(CHEMBL322034 | {N'-tert-Butoxycarbonyl-N-[2-(4-gua...)
Affinity DataIC50:  250nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50073139(2-(4-cyanophenylcarboxamido)-1,1-dimethyl-4-phenyl...)
Affinity DataIC50:  300nMAssay Description:Compound was tested by chromogenic assay for the inhibition of serine proteases like Bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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