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Found 154 of ic50 for UniProtKB: P11497
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365279(CHEMBL1958360)
Affinity DataIC50:  7nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314903(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1H-pyrazol...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314904(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1-methyl-1...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50511112(CHEMBL4567446)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of rat ACC1 using acetyl-CoA as substrate incubated for 20 mins in presence of [14C]O3 by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365287(CHEMBL1958368)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365292(CHEMBL1958373)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365293(CHEMBL1958374)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365284(CHEMBL1958365)
Affinity DataIC50:  11.5nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365290(CHEMBL1958371)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314943(1-(3,7-dimethyl-1H-indazole-5-carbonyl)-5'-isoprop...)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365281(CHEMBL1958362)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365285(CHEMBL1958366)
Affinity DataIC50:  13nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365294(CHEMBL1955895)
Affinity DataIC50:  13nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314929(6-(3,5-dimethylisoxazol-4-yl)-1'-(7-methyl-1H-inda...)
Affinity DataIC50:  13nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365277(CHEMBL1958359)
Affinity DataIC50:  14nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365276(CHEMBL1958358)
Affinity DataIC50:  15nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50127711(CHEMBL3629719)
Affinity DataIC50:  16nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314896(5-methoxy-1'-(2-phenyl-1H-benzo[d]imidazole-5-carb...)
Affinity DataIC50:  16nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314928(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(2-methylox...)
Affinity DataIC50:  17nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365295(CHEMBL1955896)
Affinity DataIC50:  17nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50439637(CHEMBL2419601)
Affinity DataIC50:  17nMAssay Description:Inhibition of rat recombinant ACC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314886(1'-(7-ethyl-1H-indazole-5-carbonyl)-6,7-dimethylsp...)
Affinity DataIC50:  17.5nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314907(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(5-methyl-1...)
Affinity DataIC50:  18nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314905(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1H-pyrazol...)
Affinity DataIC50:  18nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314901(5-methoxy-1'-(2-(1-methyl-1H-pyrazol-3-yl)-1H-benz...)
Affinity DataIC50:  19nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314927(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(2-methylox...)
Affinity DataIC50:  19nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365291(CHEMBL1958372)
Affinity DataIC50:  21nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365274(CHEMBL1958356)
Affinity DataIC50:  22nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314924(6,7-dimethyl-1'-(7-methyl-1H-indazole-5-carbonyl)s...)
Affinity DataIC50:  22nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314940(5'-isobutoxy-1-(7-methyl-1H-indazole-5-carbonyl)sp...)
Affinity DataIC50:  23nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50034371(CHEMBL3359265)
Affinity DataIC50:  24nMAssay Description:Inhibition of rat recombinant ACC1 assessed as incorporation of [14C]bicarbonate into [14C]malonyl-CoA by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314931(1-(7-methyl-1H-indazole-5-carbonyl)-6'-(1-methyl-1...)
Affinity DataIC50:  24.6nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314924(6,7-dimethyl-1'-(7-methyl-1H-indazole-5-carbonyl)s...)
Affinity DataIC50:  25nMAssay Description:Inhibition of rat recombinant ACC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314898(5-methoxy-1'-(2-(pyridin-3-yl)-1H-benzo[d]imidazol...)
Affinity DataIC50:  26nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314897(5-methoxy-1'-(2-(pyridin-2-yl)-1H-benzo[d]imidazol...)
Affinity DataIC50:  26nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50127710(CHEMBL3629720)
Affinity DataIC50:  26nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50388655(CHEMBL2059303)
Affinity DataIC50:  28nMAssay Description:Inhibition of rat ACC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365272(CHEMBL1958354)
Affinity DataIC50:  28nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365280(CHEMBL1958361)
Affinity DataIC50:  29nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314938(5'-isopropoxy-1-(7-methyl-1H-indazole-5-carbonyl)s...)
Affinity DataIC50:  30nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314906(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1-methyl-1...)
Affinity DataIC50:  31nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365283(CHEMBL1958364)
Affinity DataIC50:  31nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314939(5'-methoxy-7'-methyl-1-(7-methyl-1H-indazole-5-car...)
Affinity DataIC50:  34nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365289(CHEMBL1958370)
Affinity DataIC50:  34nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314889(5-(5-methoxy-4-oxospiro[chroman-2,4'-piperidine]-1...)
Affinity DataIC50:  35nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365282(CHEMBL1958363)
Affinity DataIC50:  36nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314926(6,7-dimethyl-1'-(3-methyl-1H-indazole-6-carbonyl)s...)
Affinity DataIC50:  36nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314888(1'-(3,7-dimethyl-1H-indazole-5-carbonyl)-5-methoxy...)
Affinity DataIC50:  42nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314894(5-(5-methoxy-4-oxospiro[chroman-2,4'-piperidine]-1...)
Affinity DataIC50:  43nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365278(CHEMBL1955891)
Affinity DataIC50:  46nMAssay Description:Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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