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Found 79 Enz. Inhib. hit(s) with all data for entry = 50016865
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597886(CHEMBL5180177)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to PRMT5 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597868(CHEMBL5202438)
Affinity DataKi: <0.0700nMAssay Description:Binding affinity to DOT1L (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597877(CHEMBL5191399)
Affinity DataKi: <0.100nMAssay Description:Binding affinity to EZH2 Y641N mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50193709(CHEMBL3911017)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to EZH2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597860(CHEMBL5172325)
Affinity DataKi:  160nMAssay Description:Binding affinity to DOT1L (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50017292(CHEMBL3287734)
Affinity DataKi:  194nMAssay Description:Binding affinity to EZH2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597869(CHEMBL5194696)
Affinity DataKi:  290nMAssay Description:Binding affinity to DOT1L (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50010823(CHEMBL3264787)
Affinity DataIC50:  0.0320nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597874(CHEMBL5188476)
Affinity DataIC50:  0.0570nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597880(CHEMBL5203719)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597863(CHEMBL5188291)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597863(CHEMBL5188291)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant DOT1L (unknown origin) using 3H-SAM/chicken erythrocyte nucleosomes as substrate preincubated for 30 mins followed by subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597867(CHEMBL5176983)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant DOT1L (unknown origin) using 3H-SAM/chicken erythrocyte nucleosomes as substrate preincubated for 30 mins followed by subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50536826(CHEMBL4590355)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597881(CHEMBL5187591)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50110357(CHEMBL3605455)
Affinity DataIC50:  2nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597884(CHEMBL5185202)
Affinity DataIC50: <2.5nMAssay Description:Inhibition of PRMT7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50193709(CHEMBL3911017)
Affinity DataIC50: <5nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50193726(CHEMBL3914083)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50544756(CHEMBL4637350)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597879(CHEMBL5180860)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50075071(CHEMBL3414619)
Affinity DataIC50: <10nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50017293(CHEMBL3287735 | US10647700, Compound GSK126)
Affinity DataIC50:  10nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597876(CHEMBL5187594)
Affinity DataIC50:  13nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597873(CHEMBL5183810)
Affinity DataIC50:  13nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597864(CHEMBL5174254)
Affinity DataIC50:  13nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597876(CHEMBL5187594)
Affinity DataIC50:  15nMAssay Description:Inhibition of wild type EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50541918(CHEMBL4641325)
Affinity DataIC50:  22nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50544764(CHEMBL4647553)
Affinity DataIC50:  31nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597852(CHEMBL5197586)
Affinity DataIC50:  38nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50075051(CHEMBL3360855 | EPZ005687 | US10273223, Compound C...)
Affinity DataIC50:  54nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597862(CHEMBL5205286)
Affinity DataIC50:  77nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597867(CHEMBL5176983)
Affinity DataIC50:  84nMAssay Description:Inhibition of DOT1L (unknown origin)-mediated H3K79 methylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597856(CHEMBL5195877)
Affinity DataIC50:  90nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597885(CHEMBL5197421)
Affinity DataIC50:  90nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597865(CHEMBL5173349)
Affinity DataIC50: <100nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597861(CHEMBL5201124)
Affinity DataIC50:  120nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597883(CHEMBL5205509)
Affinity DataIC50:  130nMAssay Description:Inhibition of SMYD3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597872(CHEMBL5196056)
Affinity DataIC50:  149nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597871(CHEMBL5200328)
Affinity DataIC50:  270nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597870(CHEMBL5182206)
Affinity DataIC50:  399nMAssay Description:Inhibition of human recombinant DOT1L by methyltransferase-Glo Bioluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50017292(CHEMBL3287734)
Affinity DataIC50:  550nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase SETD2(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597882(CHEMBL5187924)
Affinity DataIC50:  800nMAssay Description:Inhibition of SETD2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597866(CHEMBL5194873)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597852(CHEMBL5197586)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50536819(CHEMBL4534250)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597860(CHEMBL5172325)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50597860(CHEMBL5172325)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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