Report error Found 79 Enz. Inhib. hit(s) with all data for entry = 50016865
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataKi: 0.0200nMAssay Description:Binding affinity to PRMT5 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataKi: <0.0700nMAssay Description:Binding affinity to DOT1L (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataKi: <0.100nMAssay Description:Binding affinity to EZH2 Y641N mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Binding affinity to EZH2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Binding affinity to DOT1L (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataKi: 194nMAssay Description:Binding affinity to EZH2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataKi: 290nMAssay Description:Binding affinity to DOT1L (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 0.0320nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 0.0570nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant DOT1L (unknown origin) using 3H-SAM/chicken erythrocyte nucleosomes as substrate preincubated for 30 mins followed by subst...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant DOT1L (unknown origin) using 3H-SAM/chicken erythrocyte nucleosomes as substrate preincubated for 30 mins followed by subst...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 0.330nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: <2.5nMAssay Description:Inhibition of PRMT7 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 9.5nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of wild type EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of DOT1L (unknown origin)-mediated H3K79 methylationMore data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: <100nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of SMYD3 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 149nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 399nMAssay Description:Inhibition of human recombinant DOT1L by methyltransferase-Glo Bioluminescent assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SETD2(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of SETD2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
![](/img/powered_by_small.gif)