Compile Data Set for Download or QSAR
Report error Found 343 of kd data for polymerid = 50002896
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 185148BDBM185148(BMS-690514 | (3R,4R)-4-amino-1-[[4-(3-methoxyanili...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6503BDBM6503(6,7-dimethoxy-4-[(3,4,5-trimethoxyphenyl)amino]qui...)
Affinity DataKd:  0.420nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621890BDBM50621890(CHEMBL5415503)
Affinity DataKd:  1nMAssay Description:Binding affinity to GAK (unknown origin) assessed as dissociation constant by KINOME scan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50332294BDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  1.10nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4552BDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd:  1.30nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4552BDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to T7-tagged GAK (unknown origin) expressed in Escherichia coli BL21 incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4552BDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31090BDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  1.5nMAssay Description:Average Binding Constant for GAK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50524284BDBM50524284(CHEMBL4443342)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to biotinylated human GAK (13 to 338 residues) expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13216BDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  2.60nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13216BDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to GAK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13216BDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to human GAK fused to T7 bacteriophage expressed in Escherichia coli BL21 after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13216BDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  2.60nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13216BDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  2.60nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50524281BDBM50524281(CHEMBL4440586)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6511BDBM6511(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4...)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to biotinylated human GAK (13 to 338 residues) expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to GAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to GAK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.10nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to DNA-tagged human GAK expressed in Escherichia coli BL21 using immobilised ligand incubated for 1 hr by quantitative PCRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2020
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to T7-tagged GAK (unknown origin) expressed in Escherichia coli BL21 incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.10nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50524284BDBM50524284(CHEMBL4443342)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to GAK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to GAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to GAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.10nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to human GAK fused to T7 bacteriophage after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50537134BDBM50537134(CHEMBL4585158)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to biotinylated human GAK (13 to 338 residues) expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50524284BDBM50524284(CHEMBL4443342)
Affinity DataKd:  4.10nMAssay Description:Binding affinity to human wild type partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by KinomeScan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50524284BDBM50524284(CHEMBL4443342)
Affinity DataKd:  4.5nMAssay Description:Binding affinity to GAK (unknown origin) by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50537134BDBM50537134(CHEMBL4585158)
Affinity DataKd:  4.90nMAssay Description:Binding affinity to human wild type partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by KinomeScan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546115BDBM50546115(CHEMBL4781252)
Affinity DataKd:  4.90nMAssay Description:Binding affinity to human wild type partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by KinomeScan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50645313BDBM50645313(CHEMBL5566270)
Affinity DataKd:  5nMAssay Description:Binding affinity to recombinant his tagged GAK (unknown origin) assessed as dissociation constant by surface plasmon resonance methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 482158BDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  5.30nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50645312BDBM50645312(CHEMBL5574808)
Affinity DataKd:  6.20nMAssay Description:Binding affinity to recombinant his tagged GAK (unknown origin) assessed as dissociation constant by surface plasmon resonance methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50537136BDBM50537136(CHEMBL4556662)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to human wild type partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by KinomeScan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31090BDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  6.40nMAssay Description:Binding affinity to human GAK fused to T7 bacteriophage expressed in Escherichia coli BL21 after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31090BDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  6.40nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31090BDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  6.40nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50537136BDBM50537136(CHEMBL4556662)
Affinity DataKd:  6.70nMAssay Description:Binding affinity to biotinylated human GAK (13 to 338 residues) expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50095259BDBM50095259(N-(3-ethynylphenyl)-6,7-dimethoxyquinazolin-4-amin...)
Affinity DataKd:  6.80nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5447BDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  7nMAssay Description:Average Binding Constant for GAK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  7.30nMAssay Description:Binding affinity to GAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  7.30nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50645310BDBM50645310(CHEMBL5565547)
Affinity DataKd:  7.40nMAssay Description:Binding affinity to recombinant his tagged GAK (unknown origin) assessed as dissociation constant by surface plasmon resonance methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546112BDBM50546112(CHEMBL4740155)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to human wild type partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by KinomeScan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50314989BDBM50314989(N-(3-Ethynylphenyl)-6,7-dimethoxyquinolin-4-amine ...)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50537133BDBM50537133(CHEMBL4517424)
Affinity DataKd:  7.90nMAssay Description:Binding affinity to biotinylated human GAK (13 to 338 residues) expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6568BDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  8.20nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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