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Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50008968
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079090(CHEMBL90435 | [(4-{2-[4-((R)-3,10-Dibromo-8-chloro...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079085(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079075(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079079(1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079074(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14459((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079084(CHEMBL432573 | [(4-{2-[4-((R)-3,10-Dibromo-8-chlor...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079089(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079073(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079083(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of Hras Farnesyl protein transferase(FPT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079091(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079076(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  2.20nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079070(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of Hras Farnesyl protein transferase(FPT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079086(3-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of Hras Farnesyl protein transferase(FPT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079077(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079072(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  3.10nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079081(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079088(1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  4.30nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079092((S)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-...)
Affinity DataIC50:  5.20nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079087(2-[1-(2-Amino-acetyl)-piperidin-4-yl]-1-[4-((R)-3,...)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079080(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079091(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  6nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079083(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  7nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079071(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079078((R)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-...)
Affinity DataIC50:  7.90nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079074(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  8.5nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079071(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  9nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079088(1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  9nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079070(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  10nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14459((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50:  10nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079073(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  10nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079082(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  17.1nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079076(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  21nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079084(CHEMBL432573 | [(4-{2-[4-((R)-3,10-Dibromo-8-chlor...)
Affinity DataIC50:  22nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079075(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  25nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079080(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  25nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079089(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  30nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079087(2-[1-(2-Amino-acetyl)-piperidin-4-yl]-1-[4-((R)-3,...)
Affinity DataIC50:  30nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079072(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Affinity DataIC50:  35nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079078((R)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-...)
Affinity DataIC50:  39nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079081(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50:  40nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079093(2-(1-Benzenesulfonyl-piperidin-4-yl)-1-[4-((R)-3,1...)
Affinity DataIC50:  76.1nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079092((S)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-...)
Affinity DataIC50:  140nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079082(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Affinity DataIC50:  350nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079090(CHEMBL90435 | [(4-{2-[4-((R)-3,10-Dibromo-8-chloro...)
Affinity DataIC50:  360nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50079085(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed