Compile Data Set for Download or QSAR
maximum 50k data
Found 34 Enz. Inhib. hit(s) with all data for entry = 50009899
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089009((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  3nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089008(Benzoic acid 4-{(S)-2-[((S)-3-acetyl-thiazolidine-...)
Affinity DataIC50:  4nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089005((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CS-1 peptide binding to VLA-4 expressed in Ramos cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089004(2,6-Dichloro-benzoic acid 4-{(S)-2-[((S)-3-acetyl-...)
Affinity DataIC50:  6nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089006((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  9nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089001(Adamantane-1-carboxylic acid 4-{(S)-2-[((S)-3-acet...)
Affinity DataIC50:  12nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089007((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  15nMAssay Description:Inhibition of alpha4-beta1 VCAM binding in Jurkat cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089014((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  17nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089004(2,6-Dichloro-benzoic acid 4-{(S)-2-[((S)-3-acetyl-...)
Affinity DataIC50:  24nMAssay Description:Inhibition of alpha4-beta1 VCAM binding in Jurkat cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089003((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  25nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089005((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  34nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089006((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  35nMAssay Description:Inhibition of alpha4-beta1 VCAM binding in Jurkat cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089012((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  40nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089009((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  60nMAssay Description:The inhibition of PI3K-beta, PI3K-alpha, PI3K-gamma and PI3K-delta was evaluated in a Kinase Glo based enzyme activity assay using human recombinant ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089002((R)-2-[((R)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  90nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089001(Adamantane-1-carboxylic acid 4-{(S)-2-[((S)-3-acet...)
Affinity DataIC50:  140nMAssay Description:Inhibition of alpha4-beta1 VCAM binding in Jurkat cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089014((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  150nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089008(Benzoic acid 4-{(S)-2-[((S)-3-acetyl-thiazolidine-...)
Affinity DataIC50:  170nMAssay Description:Inhibition of alpha4-beta1 VCAM binding in Jurkat cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089007((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  170nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089005((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  190nMAssay Description:Inhibition of alpha4-beta7 integrin mediated cell adhesionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089013((S)-2-[((R)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  220nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089015((S)-2-[((R)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  310nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089010((S)-2-[((R)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  360nMAssay Description:The antagonist activity was evaluated by alphaIlb-beta3 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089003((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibition of alpha4-beta1 VCAM binding in Jurkat cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089011((S)-2-[((R)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  2.74E+3nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089002((R)-2-[((R)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  8.04E+3nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089013((S)-2-[((R)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  1.95E+4nMAssay Description:Inhibition of alpha4-beta1 VCAM binding in Jurkat cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089010((S)-2-[((R)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  3.53E+4nMAssay Description:Inhibition of alpha4-beta1 VCAM binding in Jurkat cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089015((S)-2-[((R)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  7.66E+4nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089005((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50: >2.00E+5nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089011((S)-2-[((R)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  2.63E+5nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089005((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50: >4.00E+5nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089005((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50: >8.00E+5nMAssay Description:Inhibition of alpha5-beta1 integrin mediated cell adhesionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Celltech Chiroscience

Curated by ChEMBL
LigandPNGBDBM50089005((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50: >8.00E+5nMAssay Description:Antagonistic activity against VLA-4 (derived from ramos cells) binding to recombinant human VCAM by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed