Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 1546
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12197BDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  11nM ΔG°:  -47.3kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12055BDBM12055((3S)-4-oxo-3-[(2-phenylbenzene)sulfonamido]butanoi...)
Affinity DataKi:  1.60E+3nM ΔG°:  -34.4kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12049BDBM12049((S)-3-(6-Methyl-biphenyl-2-sulfonylamino)-4-oxo-bu...)
Affinity DataKi:  1.90E+3nM ΔG°:  -34.0kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12054BDBM12054((S)-3-(3-Acetylamino-biphenyl-2-sulfonylamino)-4-o...)
Affinity DataKi:  2.30E+3nM ΔG°:  -33.5kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12051BDBM12051((3S)-3-{[2-(3-methylphenyl)benzene]sulfonamido}-4-...)
Affinity DataKi:  3.10E+3nM ΔG°:  -32.7kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12050BDBM12050((S)-3-(2-Methyl-biphenyl-2-sulfonylamino)-4-oxo-bu...)
Affinity DataKi:  6.80E+3nM ΔG°:  -30.7kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12053BDBM12053((3S)-3-{[2-(naphthalen-1-yl)benzene]sulfonamido}-4...)
Affinity DataKi:  6.90E+3nM ΔG°:  -30.6kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12052BDBM12052((3S)-3-{[2-(4-methylphenyl)benzene]sulfonamido}-4-...)
Affinity DataKi:  7.20E+3nM ΔG°:  -30.5kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12047BDBM12047((3S)-3-benzenesulfonamido-4-oxobutanoic acid | (S)...)
Affinity DataKi:  9.40E+3nM ΔG°:  -29.8kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12045BDBM12045((3S)-3-benzenesulfonamido-4-oxo-9-phenylnonanoic a...)
Affinity DataKi:  2.40E+4nM ΔG°:  -27.4kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12046BDBM12046((3S)-3-benzenesulfonamido-4-oxo-5-[(3-phenylpropyl...)
Affinity DataKi:  2.40E+4nM ΔG°:  -27.4kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12044BDBM12044((S)-3-Benzyloxycarbonylamino-4-oxo-5-(3-phenyl-pro...)
Affinity DataKi:  2.50E+4nM ΔG°:  -27.3kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 12043BDBM12043((S)-3-Benzyloxycarbonylamino-4-oxo-9-phenyl-nonano...)
Affinity DataKi:  1.19E+5nM ΔG°:  -23.3kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed