Compile Data Set for Download or QSAR
maximum 50k data
Found 31 Enz. Inhib. hit(s) with all data for entry = 1806
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14239(5-(carboxymethoxy)-10-{[1-(phenylmethane)sulfonylp...)
Affinity DataKi:  370nM ΔG°:  -36.7kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14239(5-(carboxymethoxy)-10-{[1-(phenylmethane)sulfonylp...)
Affinity DataKi:  380nM ΔG°:  -36.6kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14234(5-(carboxymethoxy)-10-[(cyclohexylmethyl)amino]-3,...)
Affinity DataKi:  680nM ΔG°:  -35.2kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14236(5-(carboxymethoxy)-10-(cyclohexylamino)-3,7-dithia...)
Affinity DataKi:  740nM ΔG°:  -35.0kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14233(5-(carboxymethoxy)-9-[(cyclohexylmethyl)amino]-3,7...)
Affinity DataKi:  920nM ΔG°:  -34.5kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14238(5-(carboxymethoxy)-10-{[1-(ethanesulfonyl)piperidi...)
Affinity DataKi:  1.60E+3nM ΔG°:  -33.1kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14235(5-(carboxymethoxy)-9-(cyclohexylamino)-3,7-dithiat...)
Affinity DataKi:  1.70E+3nM ΔG°:  -32.9kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14237(5-(carboxymethoxy)-10-(oxan-4-ylamino)-3,7-dithiat...)
Affinity DataKi:  2.40E+3nM ΔG°:  -32.1kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14232(5-(carboxymethoxy)-10-chloro-3,7-dithiatricyclo[6....)
Affinity DataKi:  3.50E+3nM ΔG°:  -31.1kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14230(5-(carboxymethoxy)-3,7-dithiatricyclo[6.4.0.0^{2,6...)
Affinity DataKi:  4.10E+3nM ΔG°:  -30.7kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14230(5-(carboxymethoxy)-3,7-dithiatricyclo[6.4.0.0^{2,6...)
Affinity DataKi:  9.20E+3nM ΔG°:  -28.7kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14231(5-(carboxymethoxy)-9-chloro-3,7-dithiatricyclo[6.4...)
Affinity DataKi:  1.00E+4nM ΔG°:  -28.5kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14228(5-(carboxymethoxy)-3-thiatricyclo[7.4.0.0^{2,6}]tr...)
Affinity DataKi:  1.10E+4nM ΔG°:  -28.3kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14225(3-(carboxymethoxy)-6-[(1-phenyl-1H-pyrazol-3-yl)ca...)
Affinity DataKi:  2.00E+4nM ΔG°:  -26.6kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14223(3-(carboxymethoxy)-6-(4-hydroxyphenyl)-1-benzothio...)
Affinity DataKi:  2.60E+4nM ΔG°:  -25.9kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14224(3-(carboxymethoxy)-6-(thiophen-2-yl)-1-benzothioph...)
Affinity DataKi:  3.00E+4nM ΔG°:  -25.6kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14227(3-(carboxymethoxy)-7-methyl-1-benzothiophene-2-car...)
Affinity DataKi:  3.70E+4nM ΔG°:  -25.3kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14221(6-bromo-3-(carboxymethoxy)-1-benzothiophene-2-carb...)
Affinity DataKi:  4.20E+4nM ΔG°:  -24.7kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14220(3-[carboxy(fluoro)methoxy]-6-chloro-1-benzothiophe...)
Affinity DataKi:  5.20E+4nM ΔG°:  -24.2kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14218(3-(carboxymethoxy)-6-chloro-1-benzothiophene-2-car...)
Affinity DataKi:  6.10E+4nM ΔG°:  -23.8kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14216(3-(carboxymethoxy)thieno[3,2-b]pyridine-2-carboxyl...)
Affinity DataKi:  7.70E+4nM ΔG°:  -23.2kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14226(3-(carboxymethoxy)-7-chloro-1-benzothiophene-2-car...)
Affinity DataKi:  1.19E+5nM ΔG°:  -22.4kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14222(3-(carboxymethoxy)-6-phenyl-1-benzothiophene-2-car...)
Affinity DataKi:  1.28E+5nM ΔG°:  -22.0kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14214(3-(carboxymethoxy)-1-benzothiophene-2-carboxylic a...)
Affinity DataKi:  1.60E+5nM ΔG°:  -21.4kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14211(3-(carboxymethoxy)thieno[2,3-b]pyridine-2-carboxyl...)
Affinity DataKi:  2.30E+5nM ΔG°:  -20.6kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14217(3-(carboxymethoxy)thieno[3,2-b]thiophene-2-carboxy...)
Affinity DataKi:  2.80E+5nM ΔG°:  -20.1kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14229(5-(carboxymethoxy)-3-thia-8-azatricyclo[7.4.0.0^{2...)
Affinity DataKi: >5.00E+5nM ΔG°: >-18.8kJ/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14212(3-(carboxymethoxy)naphthalene-2-carboxylic acid | ...)
Affinity DataKi:  8.60E+5nM ΔG°:  -17.3kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14215(3-(carboxymethoxy)-6-methylthieno[3,2-c]pyridine-2...)
Affinity DataKi: >2.50E+6nM ΔG°: >-14.7kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14213(3-(carboxymethoxy)furo[2,3-b]pyridine-2-carboxylic...)
Affinity DataKi: >2.50E+6nM ΔG°: >-14.7kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14219(3-(1-carboxyethoxy)-6-chloro-1-benzothiophene-2-ca...)
Affinity DataKi: >2.50E+6nM ΔG°: >-14.7kJ/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed