Compile Data Set for Download or QSAR
Report error Found 121 Enz. Inhib. hit(s) with all data for entry = 50022602
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataKi:  0.990nMAssay Description:Time-dependent inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) assessed as inhibition constant in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human MPS1 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 4.90nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 3.3 uM ATP incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 7.60nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 10 uM ATP incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCasein kinase II subunit alpha 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant CK2 (unknown origin) preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Nek6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant NEK6 (unknown origin) preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant MELK (unknown origin) preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 25nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 30 uM ATP incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 39nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 3.3 uM ATP incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 61nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 90 uM ATP incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataEC50:  65nMAssay Description:Inhibition of MPS1 in human nocodazole-arrested U2OS cells assessed as effect on histone H3 phosphorylation at ser10 residue incubated for 2 hrs by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 100nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 10 uM ATP incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant MELK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 149nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 30 uM ATP incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 182nMAssay Description:Inhibition of recombinant MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 182nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 410nMAssay Description:Inhibition of recombinant JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 510nMAssay Description:Inhibition of recombinant Haspin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 606nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 90 uM ATP incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCasein kinase II subunit alpha 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 650nMAssay Description:Inhibition of recombinant CK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 870nMAssay Description:Inhibition of recombinant KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 880nMAssay Description:Inhibition of recombinant TYK 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of recombinant IKK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of recombinant PIM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of recombinant PDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of recombinant RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM209858(Danusertib | N-[5-[(2R)-2-methoxy-2-phenylacetyl]-...)
Affinity DataEC50:  1.23E+3nMAssay Description:Inhibition of MPS1 in human taxol-arrested U2OS cells assessed as effect on histone H3 phosphorylation at ser10 residue incubated for 2 hrs by arrays...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of recombinant CDC7/DBF4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of recombinant MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataEC50:  1.99E+3nMAssay Description:Inhibition of MPS1 in human taxol-arrested U2OS cells assessed as effect on histone H3 phosphorylation at ser10 residue incubated for 2 hrs by arrays...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM31093(cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...)
Affinity DataEC50:  2.14E+3nMAssay Description:Inhibition of MPS1 in human taxol-arrested U2OS cells assessed as effect on histone H3 phosphorylation at ser10 residue incubated for 2 hrs by arrays...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM14210(N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quin...)
Affinity DataEC50:  2.28E+3nMAssay Description:Inhibition of MPS1 in human taxol-arrested U2OS cells assessed as effect on histone H3 phosphorylation at ser10 residue incubated for 2 hrs by arrays...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of recombinant ACK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 3.28E+3nMAssay Description:Inhibition of recombinant PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 3.86E+3nMAssay Description:Inhibition of recombinant FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInsulin receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 4.01E+3nMAssay Description:Inhibition of recombinant IR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 4.65E+3nMAssay Description:Inhibition of recombinant JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCasein kinase II subunit alpha 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of recombinant CK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 6.01E+3nMAssay Description:Inhibition of recombinant MELK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Nek6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 6.02E+3nMAssay Description:Inhibition of recombinant NEK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataEC50:  8.98E+3nMAssay Description:Inhibition of MPS1 in human taxol-arrested U2OS cells assessed as effect on histone H3 phosphorylation at ser10 residue incubated for 2 hrs by arrays...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant BUB1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant BUB1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein-tyrosine kinase 6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant BRK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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