Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50033008
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337494(5-(phenylethynyl)isoindoline-1,3-dione | CHEMBL168...)
Affinity DataEC50:  5.90nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337957((4-hydroxypiperidin-1-yl)(4-(phenylethynyl)phenyl)...)
Affinity DataEC50:  10nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337953(5-((2-fluorophenyl)ethynyl)isoindoline-1,3-dione |...)
Affinity DataEC50:  12nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337958(N-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinami...)
Affinity DataEC50:  16nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337950(5-((3-fluorophenyl)ethynyl)isoindoline-1,3-dione |...)
Affinity DataEC50:  35nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337503(6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one...)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337502(5-(phenylethynyl)isoindolin-1-one | CHEMBL1682798)
Affinity DataEC50:  51nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337944(2-((3-fluorophenyl)ethynyl)-6-isobutyl-7,8-dihydro...)
Affinity DataEC50:  54nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337945(6-butyl-2-((3-fluorophenyl)ethynyl)-7,8-dihydro-1,...)
Affinity DataEC50:  56nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337955(5-((3-fluorophenyl)ethynyl)isoindolin-1-one | CHEM...)
Affinity DataEC50:  66nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337963(2-butyl-6-(phenylethynyl)-3,4-dihydroisoquinolin-1...)
Affinity DataEC50:  96nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337946(6-(cyclobutylmethyl)-2-((3-fluorophenyl)ethynyl)-7...)
Affinity DataEC50:  130nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337972(6-((2-fluorophenyl)ethynyl)-3,4-dihydroisoquinolin...)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337952(5-((4-fluorophenyl)ethynyl)isoindoline-1,3-dione |...)
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337962(6-(phenylethynyl)-2-propyl-3,4-dihydroisoquinolin-...)
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337951(5-((3,4-difluorophenyl)ethynyl)isoindoline-1,3-dio...)
Affinity DataEC50:  170nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337959(2-((3-fluorophenyl)ethynyl)-6-methyl-7,8-dihydro-1...)
Affinity DataIC50: 170nMAssay Description:Antagonist activity against mGlu5 receptor assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337970(6-(m-tolylethynyl)-3,4-dihydroisoquinolin-1(2H)-on...)
Affinity DataEC50:  170nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337965(2-(cyclopropylmethyl)-6-(phenylethynyl)-3,4-dihydr...)
Affinity DataEC50:  180nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337954(5-((2-fluorophenyl)ethynyl)isoindolin-1-one | CHEM...)
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337961(2-methyl-6-(phenylethynyl)-3,4-dihydroisoquinolin-...)
Affinity DataEC50:  250nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337971(6-((4-fluorophenyl)ethynyl)-3,4-dihydroisoquinolin...)
Affinity DataEC50:  260nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337966(2-(cyclobutylmethyl)-6-(phenylethynyl)-3,4-dihydro...)
Affinity DataEC50:  270nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337943(2-((3-fluorophenyl)ethynyl)-7,8-dihydro-1,6-naphth...)
Affinity DataEC50:  290nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337956(5-((4-fluorophenyl)ethynyl)isoindolin-1-one | CHEM...)
Affinity DataEC50:  350nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337941(6-((3-chlorophenyl)ethynyl)-3,4-dihydroisoquinolin...)
Affinity DataEC50:  470nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337964(2-benzyl-6-(phenylethynyl)-3,4-dihydroisoquinolin-...)
Affinity DataEC50:  550nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337969(6-(o-tolylethynyl)-3,4-dihydroisoquinolin-1(2H)-on...)
Affinity DataEC50:  610nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337960(6-(cyclopropylmethyl)-2-((3-fluorophenyl)ethynyl)-...)
Affinity DataIC50: 660nMAssay Description:Antagonist activity against mGlu5 receptor assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337942(6-((2,4-difluorophenyl)ethynyl)-3,4-dihydroisoquin...)
Affinity DataEC50:  850nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337947(5-(phenylethynyl)-2-(2-(pyridin-2-yl)ethyl)isoindo...)
Affinity DataEC50:  870nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337948(5-(phenylethynyl)-2-(2-(pyridin-4-yl)ethyl)isoindo...)
Affinity DataEC50:  900nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337974(6-((3-methoxyphenyl)ethynyl)-3,4-dihydroisoquinoli...)
Affinity DataEC50:  3.40E+3nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337968(2-(2-morpholinoethyl)-6-(phenylethynyl)-3,4-dihydr...)
Affinity DataEC50:  3.60E+3nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337939(6-((2-chlorophenyl)ethynyl)-3,4-dihydroisoquinolin...)
Affinity DataEC50:  3.70E+3nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337967(2-(2-(azetidin-1-yl)ethyl)-6-(phenylethynyl)-3,4-d...)
Affinity DataEC50:  4.00E+3nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337938(6-((4-fluoro-3-methylphenyl)ethynyl)-3,4-dihydrois...)
Affinity DataEC50:  4.90E+3nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337949(2-(2-morpholinoethyl)-5-(phenylethynyl)isoindoline...)
Affinity DataEC50:  5.70E+3nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337973(6-((4-methoxyphenyl)ethynyl)-3,4-dihydroisoquinoli...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337940(6-((4-chlorophenyl)ethynyl)-3,4-dihydroisoquinolin...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed