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Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 4812
TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM82124(adenosine-derived inhibitor (Grp78), 1)
Affinity DataKi:  110nM ΔG°:  -39.7kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32378(adenosine-derived inhibitor (Grp78), 13 | adenosin...)
Affinity DataKi:  120nM ΔG°:  -39.5kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32381(adenosine-derived inhibitor (Grp78), 14 | adenosin...)
Affinity DataKi:  310nM ΔG°:  -37.1kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM82127((2R,3R,4S,5R)-2-(6-Amino-8-methylaminopurin-9-yl)-...)
Affinity DataKi:  450nM ΔG°:  -36.2kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32377(adenosine-derived inhibitor (Grp78), 12 | adenosin...)
Affinity DataKi:  1.05E+3nM ΔG°:  -34.1kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM82125((2R,3R,4S,5R)-2-(6-Amino-8-methylaminopurin-9-yl)-...)
Affinity DataKi:  1.10E+3nM ΔG°:  -34.0kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32375(adenosine-derived inhibitor (Grp78), 9 | adenosine...)
Affinity DataKi:  1.29E+3nM ΔG°:  -33.6kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32376(adenosine-derived inhibitor (Grp78), 11 | adenosin...)
Affinity DataKi:  1.44E+3nM ΔG°:  -33.3kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM82128(2-[(2R,3S,4R,5R)-5-(6-Amino-8-methylaminopurin-9-y...)
Affinity DataKi:  1.85E+3nM ΔG°:  -32.7kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM82126((2R,3R,4S,5R)-2-(6-Amino-8-methylaminopurin-9-yl)-...)
Affinity DataKi:  4.07E+3nM ΔG°:  -30.8kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32373(adenosine-derived inhibitor (Grp78), 8 | adenosine...)
Affinity DataKi:  4.31E+3nM ΔG°:  -30.6kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM82129((2R,3R,4S,5R)-2-{6-Amino-8-[(quinolin-2-ylmethyl)a...)
Affinity DataKi:  4.32E+3nM ΔG°:  -30.6kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32370(adenosine-derived inhibitor (Grp78), 2 | adenosine...)
Affinity DataKi:  4.46E+3nM ΔG°:  -30.5kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32371(adenosine-derived inhibitor (Grp78), 3 | adenosine...)
Affinity DataKi:  8.30E+3nM ΔG°:  -29.0kJ/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM82124(adenosine-derived inhibitor (Grp78), 1)
Affinity DataKd:  500nMpH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32370(adenosine-derived inhibitor (Grp78), 2 | adenosine...)
Affinity DataKd:  1.10E+4nMpH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32378(adenosine-derived inhibitor (Grp78), 13 | adenosin...)
Affinity DataKd:  300nMpH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM32381(adenosine-derived inhibitor (Grp78), 14 | adenosin...)
Affinity DataKd:  60nM Kon:  0.0400M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM32378(adenosine-derived inhibitor (Grp78), 13 | adenosin...)
Affinity DataKd:  80nM Kon:  0.0900M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM32377(adenosine-derived inhibitor (Grp78), 12 | adenosin...)
Affinity DataKd:  770nM Kon:  0.300M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM32376(adenosine-derived inhibitor (Grp78), 11 | adenosin...)
Affinity DataKd:  250nM Kon:  0.400M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM82129((2R,3R,4S,5R)-2-{6-Amino-8-[(quinolin-2-ylmethyl)a...)
Affinity DataKd:  2.41E+3nM Kon:  0.400M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM32375(adenosine-derived inhibitor (Grp78), 9 | adenosine...)
Affinity DataKd:  230nM Kon:  0.200M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM32373(adenosine-derived inhibitor (Grp78), 8 | adenosine...)
Affinity DataKd:  990nM Kon:  0.5M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM82128(2-[(2R,3S,4R,5R)-5-(6-Amino-8-methylaminopurin-9-y...)
Affinity DataKd:  1.24E+4nM Kon: >1M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM82127((2R,3R,4S,5R)-2-(6-Amino-8-methylaminopurin-9-yl)-...)
Affinity DataKd:  2.71E+3nM Kon: >1M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM82126((2R,3R,4S,5R)-2-(6-Amino-8-methylaminopurin-9-yl)-...)
Affinity DataKd:  4.36E+3nM Kon: >1M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM82125((2R,3R,4S,5R)-2-(6-Amino-8-methylaminopurin-9-yl)-...)
Affinity DataKd:  990nM Kon: >1M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM32371(adenosine-derived inhibitor (Grp78), 3 | adenosine...)
Affinity DataKd:  7.46E+3nM Kon: >1M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32381(adenosine-derived inhibitor (Grp78), 14 | adenosin...)
Affinity DataKd:  50nMpH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM82124(adenosine-derived inhibitor (Grp78), 1)
Affinity DataKd:  2.17E+3nM Kon:  0.00500M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndoplasmic reticulum chaperone BiP(Human)
Vernalis (R&D)

LigandPNGBDBM32370(adenosine-derived inhibitor (Grp78), 2 | adenosine...)
Affinity DataKd:  6.80E+3nM Kon: >1M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)