Compile Data Set for Download or QSAR
maximum 50k data
Found 30 Enz. Inhib. hit(s) with all data for entry = 7449
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  3nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  10nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  14nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

LigandPNGBDBM195610(KDM inhibitor, 3)
Affinity DataIC50:  20nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  20nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50:  77nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Genentech

LigandPNGBDBM60875(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Affinity DataIC50:  210nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50:  248nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50:  397nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C [1-350](Homo sapiens (Human))
Genentech

LigandPNGBDBM195610(KDM inhibitor, 3)
Affinity DataIC50:  620nMpH: 7.5Assay Description:High-throughput MS assays were carried out using truncated KDM4C in 384-well V-bottom polypropylene plates (Greiner, Inc.). His-tagged recombinant KD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Genentech

LigandPNGBDBM60875(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Affinity DataIC50:  1.20E+3nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50:  1.50E+3nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C [1-350](Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  2.00E+3nMpH: 7.5Assay Description:High-throughput MS assays were carried out using truncated KDM4C in 384-well V-bottom polypropylene plates (Greiner, Inc.). His-tagged recombinant KD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

LigandPNGBDBM60875(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Affinity DataIC50:  2.90E+3nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4C [1-350](Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50:  3.00E+3nMpH: 7.5Assay Description:High-throughput MS assays were carried out using truncated KDM4C in 384-well V-bottom polypropylene plates (Greiner, Inc.). His-tagged recombinant KD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 6A(Homo sapiens (Human))
Genentech

LigandPNGBDBM60875(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Affinity DataIC50:  3.20E+3nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
TargetHistone lysine demethylase PHF8(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  7.70E+3nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  9.10E+3nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C [1-350](Homo sapiens (Human))
Genentech

LigandPNGBDBM60875(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Affinity DataIC50:  1.33E+4nMpH: 7.5Assay Description:High-throughput MS assays were carried out using truncated KDM4C in 384-well V-bottom polypropylene plates (Greiner, Inc.). His-tagged recombinant KD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  1.53E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50: >2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2B(Homo sapiens (Human))
Genentech

LigandPNGBDBM60875(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Affinity DataIC50: >2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3B(Homo sapiens (Human))
Genentech

LigandPNGBDBM60875(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Affinity DataIC50: >2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 6A(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50: >2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone lysine demethylase PHF8(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50: >2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone lysine demethylase PHF8(Homo sapiens (Human))
Genentech

LigandPNGBDBM60875(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Affinity DataIC50: >2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50: >2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50: >2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 6A(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50: >2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50: >2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed