Compile Data Set for Download or QSAR
Report error Found 59 Enz. Inhib. hit(s) with all data for entry = 50022564
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of SMYD3 (unknown origin) N-terminal GST-tagged MAP3K2 and 3H-SAM as substrate for 2 hrs by TopCount NXT plate readerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 3nMAssay Description:Inhibition of SMYD2 in human HEK293T cells assessed as BTF3me1 levels by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetN-lysine methyltransferase SMYD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of SMYD2 (unknown origin) using N-terminal GST-tagged MAP3K2 and 3H-SAM as substrate for 2 hrs by TopCount NXT plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652925(CHEMBL3798468)
Affinity DataIC50: 4nMAssay Description:Inhibition of SMYD3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378462(6-chloro-2-oxo-N-((1R,3r,5S)-8-(((1-(4,4,4-trifluo...)
Affinity DataIC50: 5nMAssay Description:Inhibition of SMYD3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 16nMAssay Description:Inhibition of SMYD2 (unknown origin) using N-terminal GST-tagged MAP3K2 and 3H-SAM as substrate for 2 hrs by TopCount NXT plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 17nMAssay Description:Inhibition of SMYD2 (unknown origin) using N-terminal GST-tagged MAP3K2 and 3H-SAM as substrate for 2 hrs by TopCount NXT plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50180955(CHEMBL3818617)
Affinity DataIC50: 27nMAssay Description:Inhibition of SMYD2 (unknown origin) assessed as methylation of Btn-Ahx-GSRAHS-SHLKSKKGQSTSRH-amide peptide in presence of 3H-SAM by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 31nMAssay Description:Inhibition of SMYD2 in human HEK293T cells assessed as BTF3me1 levels by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 32nMAssay Description:Inhibition of SMYD3 in human HEK293T cells co-transfected with MAP3K assessed as inhibition of Lys260 methylation of MAP3K2 by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50396022(CHEMBL2169920)
Affinity DataIC50: 51nMAssay Description:Inhibition of SMYD2 (unknown origin) using N-terminal GST-tagged MAP3K2 and 3H-SAM as substrate for 2 hrs by TopCount NXT plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetN-lysine methyltransferase SMYD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50180955(CHEMBL3818617)
Affinity DataIC50: 58nMAssay Description:Inhibition of N-terminal 2xc-myc-tagged SMYD2 (unknown origin) transfected in KYSE-150 cells assessed as methylation activity by Western blot analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652923(CHEMBL5203609)
Affinity DataIC50: 130nMAssay Description:Inhibition of SMYD3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 691nMAssay Description:Inhibition of SMYD2 in human HEK293T cells assessed as BTF3me1 levels by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataEC50:  1.40E+3nMAssay Description:Binding affinity to SMYD3 in human A549 cells for 60 mins by cellular thermal shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EHMT1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EHMT1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EHMT1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EZH1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EHMT2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EHMT2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EHMT2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EZH1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EZH1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SETD7 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SETD7 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SETD2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SETD2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SETD7 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of WHSC1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of WHSC1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of WHSC1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT3 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRDM9 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRDM9 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRDM9 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT6 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT6 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT3 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT3 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT7 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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