Compile Data Set for Download or QSAR
Report error Found 81 Enz. Inhib. hit(s) with all data for entry = 50007770
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 364467BDBM364467(US9862707, Example 41)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512439BDBM50512439(CHEMBL4449648)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512442BDBM50512442(CHEMBL4554856)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 364459BDBM364459(US9862707, Example 33 | US9862707, Example 34 | (R...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512453BDBM50512453(CHEMBL4437772)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512442BDBM50512442(CHEMBL4554856)
Affinity DataIC50: 0.536nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512425BDBM50512425(CHEMBL4541382)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of human TRKA expressed in human TF1 cells by CellTiter-Glo Luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512451BDBM50512451(CHEMBL4471633)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of human TRKA expressed in human TF1 cells by CellTiter-Glo Luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512426BDBM50512426(CHEMBL4528960)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of human TRKA expressed in human TF1 cells by CellTiter-Glo Luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 364431BDBM364431(US9862707, Example 5 | 2-fluoro-5-(1-methyl-1H-pyr...)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512454BDBM50512454(CHEMBL4459162)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512420BDBM50512420(CHEMBL4469681)
Affinity DataIC50: 1nMAssay Description:Inhibition of N- terminal GST-tagged human TRKA cytoplasmic domain (436 to 790 end residues) using TK peptide as substrate after 60 mins by HTRF assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512429BDBM50512429(CHEMBL4457005)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512429BDBM50512429(CHEMBL4457005)
Affinity DataIC50: 1nMAssay Description:Inhibition TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512430BDBM50512430(CHEMBL4467309)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512431BDBM50512431(CHEMBL4461026)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512422BDBM50512422(CHEMBL4589669)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512430BDBM50512430(CHEMBL4467309)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKA/TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512422BDBM50512422(CHEMBL4589669)
Affinity DataIC50: 1nMAssay Description:Inhibition TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512418BDBM50512418(CHEMBL4438294)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512438BDBM50512438(CHEMBL4549982)
Affinity DataIC50: 1nMAssay Description:Inhibition of N- terminal GST-tagged human TRKA cytoplasmic domain (436 to 790 end residues) using TK peptide as substrate after 60 mins by HTRF assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512450BDBM50512450(CHEMBL4444487)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant His-tagged human TRKA cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression system using biotin labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512448BDBM50512448(CHEMBL4539407)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant His-tagged human TRKA cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression system using biotin labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512422BDBM50512422(CHEMBL4589669)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKA/TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512434BDBM50512434(CHEMBL4515809)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512431BDBM50512431(CHEMBL4461026)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKA/TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512429BDBM50512429(CHEMBL4457005)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKA/TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512434BDBM50512434(CHEMBL4515809)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKA/TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512447BDBM50512447(CHEMBL4437728)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512433BDBM50512433(CHEMBL4443081)
Affinity DataIC50: 1.30nMAssay Description:Inhibition TRKA (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512433BDBM50512433(CHEMBL4443081)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 398968BDBM398968(US10323022, Example 445)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512447BDBM50512447(CHEMBL4437728)
Affinity DataIC50: 1.90nMAssay Description:Inhibition TRKA (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512434BDBM50512434(CHEMBL4515809)
Affinity DataIC50: 2nMAssay Description:Inhibition TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512430BDBM50512430(CHEMBL4467309)
Affinity DataIC50: 2nMAssay Description:Inhibition TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 136597BDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 2nMAssay Description:Inhibition of TRKA (unknown origin) assessed as reduction in incorporation of [33P]PO4 from [gamma-33P]-ATP using poly-EAY peptide as substrate by Fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503234BDBM50503234(CHEMBL4575703)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant His-tagged human TRKA cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression system using biotin labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512431BDBM50512431(CHEMBL4461026)
Affinity DataIC50: 3nMAssay Description:Inhibition TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512432BDBM50512432(CHEMBL4589373)
Affinity DataIC50: 3.80nMAssay Description:Inhibition TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335202BDBM50335202(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human JAK2 (808 to end residues) expressed in baculovirus infected SF21 insect cells using Tyr 1054/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512432BDBM50512432(CHEMBL4589373)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512444BDBM50512444(CHEMBL4555588)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of recombinant His-tagged human TRKA cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression system using biotin labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 398968BDBM398968(US10323022, Example 445)
Affinity DataIC50: 6.10nMAssay Description:Inhibition TRKA (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392788BDBM50392788(CHEMBL457614)
Affinity DataIC50: 8nMAssay Description:Inhibition of human TRKA expressed in human MCF10A cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512443BDBM50512443(CHEMBL4452467)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of recombinant His-tagged human TRKA cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression system using biotin labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512439BDBM50512439(CHEMBL4449648)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512420BDBM50512420(CHEMBL4469681)
Affinity DataIC50: 10nMAssay Description:Inhibition of N- terminal GST-tagged human TRKC catalytic domain (456 to 825 end residues) expressed in baculovirus expression system using TK peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512428BDBM50512428(CHEMBL4556980)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant N- terminal GST-tagged human NTRK1 expressed in baculovirus infected Sf9 cells using Poly(Glu:Tyr) as substrate after 45 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 10nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 410189BDBM410189(5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrr...)
Affinity DataIC50: 10nMAssay Description:Inhibition of NTRK1 in human KM12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
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