Compile Data Set for Download or QSAR
maximum 50k data
Found 29 Enz. Inhib. hit(s) with all data for entry = 50017646
TargetProtein kinase C theta type(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of full length human PKCtheta using 5-FAM-RFARKGSLRQKNV-OH peptide substrate incubated for 30 mins by IMAP kinase assayMore data for this Ligand-Target Pair
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TargetAurora kinase A(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of AURA (unknown origin)More data for this Ligand-Target Pair
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TargetProtein kinase C beta type(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of PKCbeta1 (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
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TargetProtein kinase C alpha type(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  0.950nMAssay Description:Inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of AURA (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PKCnu (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
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TargetAurora kinase C(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM26326(1-(3-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  3nMAssay Description:Inhibition of AURC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PKCepsilon (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PKCeta (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
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TargetcAMP-dependent protein kinase catalytic subunit gamma(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of AURC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM17055((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of PKCbeta1 (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataIC50:  5nMAssay Description:Inhibition of AURB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM17055((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of PKCbeta2 (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PKbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of AURC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50277583(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin...)
Affinity DataIC50:  8nMAssay Description:Inhibition of AURA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM26326(1-(3-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  9nMAssay Description:Inhibition of AURA (unknown origin)More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50277583(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of AURB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM209858(Danusertib | N-[5-[(2R)-2-methoxy-2-phenylacetyl]-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of AURA (unknown origin)More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  18nMAssay Description:Inhibition of AURB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM26326(1-(3-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  31nMAssay Description:Inhibition of AURB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM209858(Danusertib | N-[5-[(2R)-2-methoxy-2-phenylacetyl]-...)
Affinity DataIC50:  61nMAssay Description:Inhibition of AURC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM209858(Danusertib | N-[5-[(2R)-2-methoxy-2-phenylacetyl]-...)
Affinity DataIC50:  79nMAssay Description:Inhibition of AURB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataIC50: >200nMAssay Description:Inhibition of AURA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM17055((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)
Affinity DataIC50:  360nMAssay Description:Inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  396nMAssay Description:Inhibition of AURB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM25549(4-[(4-chlorophenyl)amino]-5-(3,4-dimethoxyphenyl)p...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of full length human PKCtheta using 5-FAM-RFARKGSLRQKNV-OH peptide substrate incubated for 30 mins by IMAP kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50126829((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of PKCdelta (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed