Compile Data Set for Download or QSAR
Report error Found 51 Enz. Inhib. hit(s) with all data for entry = 50022246
TargetFibroblast growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FGFR1 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM669888(US20240132517, Example TPX-0022 | Example 5 of WO...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM560618(US11384065, Compound 15)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of human CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM239022(US9408850, 33 | US10028934, Compound 33 | US959731...)
Affinity DataKd: <1nMAssay Description:Binding affinity to human FLT3 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM239022(US9408850, 33 | US10028934, Compound 33 | US959731...)
Affinity DataKd: <1nMAssay Description:Binding affinity to CSF1R (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM192716(YKL-05-099 (5) | US11725011, Compound YKL-05-99)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR2 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM560613(US11384065, Compound 10)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant FLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM595552(US11591328, Compound 1)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of CSF1R in human THP-1 cells assessed as reduction in AKT phosphorylation measured after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human recombinant SIK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of FGFR3 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649858(Derazantinib | Arq-087 | ARQ 087 | ARQ087)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CSF1R (unknown origin) in presence of ATP by Z-LYTE based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 4nMAssay Description:Inhibition of human MERTK by discoverX kinome scan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of CSF1R in mouse BMDM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649859(Ibcasertib | Chiauranib | Cs-2164 | CS-2164 | CS21...)
Affinity DataIC50: 7nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM132068(US8841455, 65 Step D)
Affinity DataIC50: 9nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468397(CHEMBL4276742 | US11834432, Compound S10)
Affinity DataIC50: 10nMAssay Description:Inhibition of human VEGFR2 in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468397(CHEMBL4276742 | US11834432, Compound S10)
Affinity DataIC50: 10nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 12nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50518402(CHEMBL4532017)
Affinity DataIC50: 13nMAssay Description:Inhibition of human CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50356877(CHEMBL1614710)
Affinity DataIC50: 15nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50356877(CHEMBL1614710)
Affinity DataIC50: 15nMAssay Description:Inhibition of c-RAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50356877(CHEMBL1614710)
Affinity DataIC50: 15nMAssay Description:Inhibition of KDR (unknown origin) using peptide as substrate incubated for 90 mins in presence of ATP by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468397(CHEMBL4276742 | US11834432, Compound S10)
Affinity DataIC50: 15nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 15nMAssay Description:Inhibition of FGFR1 (unknown origin) by trFRET binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM595651(US11591328, Compound 4)
Affinity DataIC50: 16nMAssay Description:Inhibition of CSF1R in human THP-1 cells assessed as reduction in AKT phosphorylation measured after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM174948(US9096593, P-2049)
Affinity DataIC50: 16nMAssay Description:Inhibition of human CSF1R by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649856(CHEMBL5631034)
Affinity DataIC50: 20nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 20nMAssay Description:Inhibition of c-KIT (unknown origin) using TK as substrate incubated for 50 mins in presence of ATP by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5919(3-[4-(7-methoxy-1-oxo-2,3-dihydro-1H-isoindol-4-yl...)
Affinity DataIC50: 21nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649861(CHEMBL5630625)
Affinity DataIC50: 23nMAssay Description:Inhibition of CSF1R (unknown origin) preincubated for 60 mins measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM174948(US9096593, P-2049)
Affinity DataIC50: 26nMAssay Description:Inhibition of CSF1R autophosphorylation in mouse RAW264.7 cells measured after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649857(CHEMBL5630959)
Affinity DataIC50: 38nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM192716(YKL-05-099 (5) | US11725011, Compound YKL-05-99)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant SIK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 41nMAssay Description:Inhibition of TRKB (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 50nMAssay Description:Inhibition of CSF1R in mouse RAW264.7 cells assessed as increase in M1 macrophage phenotype measured after 72 hrs by Real-time PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 67nMAssay Description:Inhibition of wild type FLT3 (unknown origin) phosphorylation in human RS4-11 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 79nMAssay Description:Inhibition of CSF1R in mouse RAW264.7 cells assessed as reduction in AKT phosphorylation measured after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375796(US9914707, I-21 | US20230382871, Compound I)
Affinity DataIC50: 93nMAssay Description:Inhibition of CSF1R in mouse BMDM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649860(CHEMBL5630293)
Affinity DataKd: <100nMAssay Description:Binding affinity to CSF1R (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 190nMAssay Description:Inhibition of FLT3-ITD mutant phosphorylation in human HEK-293T cells incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649858(Derazantinib | Arq-087 | ARQ 087 | ARQ087)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant N-terminal GST tagged FGFR3 (436 to 806 residues) (unknown origin) expressed in Sf21 cells using biotinylated PYK2 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50649858(Derazantinib | Arq-087 | ARQ 087 | ARQ087)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant N-terminal GST tagged FGFR2 (399 to 821 residues) (unknown origin) expressed in Sf21 cells using biotinylated PYK2 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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